Chapter 1
Unmet Medical Needs in Life-Threatening Infections – Caring for the Critically Ill
Michael Bauer,
Andreas Kortgen,
Mervyn Singer,
Michael Bauer
Prof. Dr.
Jena University Hospital, Department of Anesthesiology and Intensive Care Medicine, Germany
Center for Sepsis Control and Care (CSCC), Erlanger Allee 101, 07747 Jena, Germany
Search for more papers by this authorAndreas Kortgen
Jena University Hospital, Friedrich-Schiller-University, Department of Anesthesiology and Intensive Care Medicine, Erlanger Allee 101, 07747, Jena, Germany
Jena University Hospital, CSCC, Center for Sepsis Control and Care, Erlanger Allee 101, 07747, Jena, Germany
Search for more papers by this authorMervyn Singer
InfectoGnostics, Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, D-07743, Jena, Germany
University College London, Bloomsbury Institute of Intensive Care Medicine, Cruciform Building, Gower Street, WC1E 6BT3, London, UK
Search for more papers by this authorMichael Bauer,
Andreas Kortgen,
Mervyn Singer,
Michael Bauer
Prof. Dr.
Jena University Hospital, Department of Anesthesiology and Intensive Care Medicine, Germany
Center for Sepsis Control and Care (CSCC), Erlanger Allee 101, 07747 Jena, Germany
Search for more papers by this authorAndreas Kortgen
Jena University Hospital, Friedrich-Schiller-University, Department of Anesthesiology and Intensive Care Medicine, Erlanger Allee 101, 07747, Jena, Germany
Jena University Hospital, CSCC, Center for Sepsis Control and Care, Erlanger Allee 101, 07747, Jena, Germany
Search for more papers by this authorMervyn Singer
InfectoGnostics, Forschungscampus Jena, Zentrum für Angewandte Forschung, Philosophenweg 7, D-07743, Jena, Germany
University College London, Bloomsbury Institute of Intensive Care Medicine, Cruciform Building, Gower Street, WC1E 6BT3, London, UK
Search for more papers by this authorBook Editor(s):Jürgen Popp,
Michael Bauer,
Jürgen Popp
Prof. Dr.
Friedrich-Schiller University Jena and Abbe Center of Photonics, Institute of Physical Chemistry, Helmholtzweg 4, 07743 Jena, Germany
Leibniz Institute of Photonic Technology, Albert-Einstein-Straße 9, 07745 Jena, Germany
Search for more papers by this authorMichael Bauer
Prof. Dr.
Jena University Hospital, Department of Anesthesiology and Intensive Care Medicine, Germany
Center for Sepsis Control and Care (CSCC), Erlanger Allee 101, 07747 Jena, Germany
Search for more papers by this authorFirst published: 27 February 2015
Summary
The diagnostic uncertainty regarding the causative pathogen reflects a central dilemma of intensive care physicians in treating life-threatening infections. On one hand, there is an important need to avoid delays in the initiation of appropriate antibiotics, yet this, in turn, triggers the overuse of “broad spectrum” antimicrobial agents creating a tremendous problem with multi-resistant pathogens. Sepsis arises from community-acquired infections but also, and more frequently, from healthcare-associated infections. Methicillin-resistant Staphylococcus aureus (MRSA) remains an important cause of healthcare-associated infections, and is endemic in most hospitals. Bacteria dominate as the type of pathogen responsible for most life-threatening infections in the “immune competent” host. Viruses may play an important role in complicating the course of defined intensive care unit (ICU) patient populations. Unmet medical needs and strategies to improve patient care will most likely be achieved via improved diagnostics to identify the pathogen and to describe the immune status early.
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