Chapter 12
Promises of the Unprecedented Aminosterol Squalamine
Marie-Lise Bourguet-Kondracki,
Jean-Michel Brunel,
Marie-Lise Bourguet-Kondracki
Muséum National d'Histoire Naturelle, Molécules de Communication et Adaptation des Micro-Organismes (MCAM) UMR 7245 CNRS/MNHN, 57 rue Cuvier (CP 54), 75005, Paris, France
Search for more papers by this authorJean-Michel Brunel
Aix-Marseille Université, Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes, UM 105; Inserm, U1068, F-13009, Marseille, France
Search for more papers by this authorMarie-Lise Bourguet-Kondracki,
Jean-Michel Brunel,
Marie-Lise Bourguet-Kondracki
Muséum National d'Histoire Naturelle, Molécules de Communication et Adaptation des Micro-Organismes (MCAM) UMR 7245 CNRS/MNHN, 57 rue Cuvier (CP 54), 75005, Paris, France
Search for more papers by this authorJean-Michel Brunel
Aix-Marseille Université, Centre de Recherche en Cancérologie de Marseille (CRCM), CNRS, UMR7258; Institut Paoli Calmettes, UM 105; Inserm, U1068, F-13009, Marseille, France
Search for more papers by this authorBook Editor(s):Stéphane La Barre,
Jean-Michel Kornprobst,
Stéphane La Barre
Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
Search for more papers by this authorJean-Michel Kornprobst
Institut Mer et Littoral,Bâtiment Isomer, 2, rue de la Houssinière, 44322 Nantes, BP 92208,Cedex 3, France
Search for more papers by this authorSummary
Squalamine, a water-soluble cationic steroid that was originally isolated during the 1990s from the dogfish Squalus acanthias, has begun to attract attention due to its significant antimicrobial activities against fungi, Gram-positive and Gram-negative bacteria. Additionally, this unusual sulfated aminosterol could be a very promising leader of a new class of drugs in the antiangiogenic, anticancer and antiviral fields. In this chapter, a current overview is provided of all the potentialities of this remarkable aminosteroid and its mimics in human disease treatment.
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