Chapter 3
Impact of Marine-Derived Penicillium Species in the Discovery of New Potential Antitumor Drugs
Marieke Vansteelandt,
Catherine Roullier,
Elodie Blanchet,
Yann Guitton,
Yves-François Pouchus,
Nicolas Ruiz,
Olivier Grovel,
Marieke Vansteelandt
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorCatherine Roullier
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorElodie Blanchet
Atlanthera, Atlantic Bone Screen, F-44800, Saint Herblain, Nantes, France
Search for more papers by this authorYann Guitton
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorYves-François Pouchus
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorNicolas Ruiz
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorOlivier Grovel
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorMarieke Vansteelandt,
Catherine Roullier,
Elodie Blanchet,
Yann Guitton,
Yves-François Pouchus,
Nicolas Ruiz,
Olivier Grovel,
Marieke Vansteelandt
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorCatherine Roullier
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorElodie Blanchet
Atlanthera, Atlantic Bone Screen, F-44800, Saint Herblain, Nantes, France
Search for more papers by this authorYann Guitton
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorYves-François Pouchus
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorNicolas Ruiz
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorOlivier Grovel
University of Nantes, Faculty of Pharmacy, MMS, 9 rue Bias, F-44000, Nantes, Cedex 1, France
Search for more papers by this authorBook Editor(s):Stéphane La Barre,
Jean-Michel Kornprobst,
Stéphane La Barre
Sorbonne Universités, UPMC Univ Paris 06, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
CNRS, UMR 8227, Integrative Biology of Marine Models, Station Biologique de Roscoff, CS 90074, F-29688 Roscoff cedex, France
Search for more papers by this authorJean-Michel Kornprobst
Institut Mer et Littoral,Bâtiment Isomer, 2, rue de la Houssinière, 44322 Nantes, BP 92208,Cedex 3, France
Search for more papers by this authorSummary
Since the discovery of penicillin, Penicillium has become one of the most well-known genera of fungi for the discovery of bioactive compounds. The genus Penicillium is ubiquitous and widespread in all environments, and especially in marine coastal zones where it represents half of the fungal species present. In this chapter, attention is focused on the importance of marine-derived Penicillium strains in the discovery of potential new antitumor drugs. A detailed review of potent cytotoxic compounds isolated from marine-derived Penicillium spp. is presented. Three examples are then provided to yield some insight into the chemistry of these compounds, and to help assess the chemical diversity that marine-derived Penicillium spp. are capable of producing.
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