Fucosyltransferases
Ernesto T. A. Marques Jr.
Search for more papers by this authorErnesto T. A. Marques Jr.
Search for more papers by this authorProf. Dr. Beat Ernst
Institut für Molekulare Pharmazie, Universität Basel, Klingenbergstrasse 50, 4051 Basel, Switzerland
Search for more papers by this authorProf. Dr. Gerald W. Hart
Dept. of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolf St. Rm., 401 Hunterian Baltimore, MD 21205-2185, USA
Search for more papers by this authorProf. Dr. Pierre Sinaý
Dept. de Chimie, URA 1686, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
Search for more papers by this authorProf. Dr. Beat Ernst
Institut für Molekulare Pharmazie, Universität Basel, Klingenbergstrasse 50, 4051 Basel, Switzerland
Search for more papers by this authorProf. Dr. Gerald W. Hart
Dept. of Biological Chemistry, Johns Hopkins University School of Medicine, 725 N. Wolf St. Rm., 401 Hunterian Baltimore, MD 21205-2185, USA
Search for more papers by this authorProf. Dr. Pierre Sinaý
Dept. de Chimie, URA 1686, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 05, France
Search for more papers by this authorSummary
The prelims comprise:
-
Introduction
-
General Characteristics
-
Specific Fucosyltransferases
References
- D. R. Howard, M. Fukuda, M. N. Fukuda, P. Stanley, The GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferases of LECH and LEC12 Chinese hamster ovary mutants exhibit novel specificities for glycolipid substrates, J. Biol Chem, 1987, 262, 16830–7.
- J. F. Kukowska-Latallo, R. D. Larsen, R. P. Nair, J. B. Lowe, A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase, Genes Dev, 1990, 4, 1288–303.
- B. W. Weston, P. L. Smith, R. J. Kelly, J. B. Lowe, Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes [published erratum appears in J Biol Chem 1993 Aug 25, 268(24): 18398], J Biol Chem, 1992, 267, 24575–84.
- B. W. Weston, R. P. Nair, R. D. Larsen, J. B. Lowe, Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities, J Biol Chem, 1992, 267, 4152–60.
- S. Natsuka, K. M. Gersten, K. Zenita, R. Kannagi, J. B. Lowe, Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant, J Biol Chem, (1994), 269, 20806.
- S. Natsuka, K. M. Gersten, K. Zenita, R. Kannagi, J. B. Lowe, Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant [published erratum appears in J Biol Chem 1994 Aug 12;269(32):20806], J. Biol Chem, 1994, 269, 16789–94.
- J. B. Lowe, J. F. Kukowska-Latallo, R. P. Nair, R. D. Larsen, R. M. Marks, B. A. Macher, R. J. Kelly, L. K. Ernst, Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion, J Biol Chem, 1991, 266, 17467–77.
- K. Sasaki, K. Kurata, K. Funayama, M. Nagata, E. Watanabe, S. Ohta, N. Hanai, T. Nishi, Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes, J Biol Chem, 1994, 269, 14730–7.
- M. Costache, A. Cailleau, P. Fernandez-Mateos, R. Oriol, R. Mollicone, Advances in molecular genetics of alpha-2-and alpha-3/4-fucosyltransferases, Transfus Clin Biol, 1997, 4, 367–82.
- M. Costache, P. A. Apoil, A. Cailleau, A. Elmgren, G. Larson, S. Henry, A. Blancher, D. lordachescu, R. Oriol, R. Mollicone, Evolution of fucosyltransferase genes in vertebrates, J Biol Chem, 1997, 272, 29721–8.
- S. Goelz, R. Kumar, B. Potvin, S. Sundaram, M. Brickelmaier, P. Stanley, Differential expression of an E-selectin ligand (SLex) by two Chinese hamster ovary cell lines transfected with the same alpha (1,3)-fucosyltransferase gene (ELFT), J Biol Chem, 1994, 269, 1033–40.
- S. Yanagidani, N. Uozumi, Y. lhara, E. Miyoshi, N. Yamaguchi, N. Taniguchi, Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alphal-6 fucosyltransferase (alphal-6 FucT) from human gastric cancer MKN45 cells, J Biochem (Tokyo), 1997, 121, 626–32.
- T. Kudo, Y. Ikehara, A. Togayachi, M. Kaneko, T. Hiraga, K. Sasaki, H. Narimatsu, Expression cloning and characterization of a novel murine alpha 1,3-fucosyltransferase, mFuc-TIX, that synthesizes the lewis x (CD 15) epitope in brain and kidney, J. Biol Chem, 1998, 273, 26729–38.
- A. Oulmouden, A. Wierinckx, J. M. Petit, M. Costache, M. M. Palcic, R. Mollicone, R. Oriol, R. Julien, Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3–FUT5-FUT6 cluster, J Biol Chem, 1997, 272, 8764–73.
- C. Breton, R. Oriol, A. Imberty, Conserved structural features in eukaryotic and prokaryotic fucosyltransferases, Glyeohiology, 1998, 8, 87–94.
- A. T. Nguyen, E. H. Holmes, J. M. Whitaker, S. Ho, S. Shetterly, B. A. Macher, Human alpha 1,3/4-fucosyltransferases. I. Identification of amino acids involved in acceptor substrate binding by site-directed mutagenesis, J Biol Chem, 1998, 273, 25244–9.
- M. Du, O. Hindsgaul, Recognition of beta-D-Gal β-(1→3)-beta-D-Glc pNAc-OR acceptor analogues by the Lewis alpha-(1→3/4)-fucosyltransferase from human milk, Carhohydr Res, 1996, 286, 87–105.
- Z. Xu, L. Vo, B. A. Macher, Structure-function analysis of human alpha 1,3-fucosyltransferase. Amino acids involved in acceptor substrate specificity, J. Biol Chem, 1996, 271, 8818–23.
- L. Vo, S. Lee, M. C. Marcinko, E. H. Holmes, B. A. Macher, Human alpha 1,3/4-fucosyl-transferases. II. A single amino acid at the COOH terminus of FucT III and V alters their kinetic properties, J. Biol Chem, 1998, 273, 25250–5.
- B. W. Murray, S. Takayama, J. Schultz, C. H. Wong, Mechanism and specificity of human alpha-1,3-fucosyltransferase V, Biochemistry, 1996, 35, 11183–95.
- A. L. Sherwood, A. T. Nguyen, J. M. Whitaker, B. A. Macher, M. R. Stroud, E. H. Holmes, Human alpha 1,3/4–fucosyltransferases. III. A Lys/Arg residue located within the alpha1,3-FucT motif is required for activity but not substrate binding, J Biol Chem, 1998, 273, 25256–60.
- B. W. Murray, V. Wittmann, M. D. Burkart, S. C. Hung, C. H. Wong, Mechanism of human alpha-1,3-fucosyltransferase V: glycosidic cleavage occurs prior to nucleophilic attack, Biochemistry, 1997, 36, 823–31.
- E. H. Holmes, Z. Xu, A. L. Sherwood, B. A. Macher, Structure-function analysis of human alpha 1→3 fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Serl78 in FucT-IV, J Biol Chem, 1995, 270, 8145–51.
- C. J. Britten, M. I. Bird, Chemical modification of an alpha 3-fucosyltransferase; definition of amino acid residues essential for enzyme activity, Biochim Biophys Acta, 1997, 1334, 57–64.
- L. Qiao, B. Murray, M. Shimazaki, S. J., W. C-H., Synergistic Inhibition of human α1,3-fucosyltransferase V, Journal of the American Chemical Society, 1996, 118, 7653–7662.
- S. B. Levery, J. B. Weiss, M. E. Salyan, C. E. Roberts, S. Hakomori, J. L. Magnani, M. Strand, Characterization of a series of novel fucose-containing glycosphingolipid immunogens from eggs of Schistosoma mansoni, J Biol Chem, 1992, 267, 5542–51.
- Khoo Kh, Chatterjee D, Caulfield JP, Morris HR, Dell A, Structural characterization of glycosphingolipids from the eggs of Schistosoma mansoni and Schistosoma japonicum, Glyco biology, 1997, 7, 653–661.
- K. H. Khoo, S. Sarda, X. Xu, J. P. Caulfield, M. R. McNeil, S. W. Homans, H. R. Morris, A. Dell, A unique multifucosylated -3GalNAc beta 1→4 GlcNAc beta 1→3 Gal alpha 1-motif constitutes the repeating unit of the complex O-glycans derived from the cercarial glycocalyx of Schistosoma mansoni, J Biol Chem, 1995, 270, 17114–23.
- C. H. Hokke, A. P. Neeleman, C. A. Koeleman, D. H. van den Eijnden, Identification of an alpha3-fucosyltransferase and a novel alpha2-fucosyltransferase activity in cercariae of the schistosome Trichobilharzia ocellata: biosynthesis of the Fucalpha 1→2 Fucalpha1→3[Gal(NAc)beta1→4]GlcNAc sequence, Glycobiology, 1998, 8, 393–406.
- E. T. Marques Jr., J. B. Weiss, M. Strand, Molecular characterization of a fucosyltransferase encoded by Schistosoma mansoni, Mol Biochem Parasitol, 1998, 93, 237–50.
- S. Hitoshi, S. Kusunoki, I. Kanazawa, S. Tsuji, Molecular cloning and expression of a third type of rabbit GDP-Lfucose:beta-D-galactoside 2-alpha-L-fucosyltransferase, J Biol Chem, 1996, 271, 16975–81.
- P. A. Prieto, R. D. Larsen, M. Cho, H. N. Rivera, A. Shilatifard, J. B. Lowe, R. D. Cummings, D. F. Smith, Expression of human H-type alpha 1,2-fucosyltransferase encoding for blood group H(O) antigen in Chinese hamster ovary cells. Evidence for preferential fucosylation and truncation of polylactosamine sequences, J Biol Chem, 1997, 272, 2089–97.
- S. Hitoshi, S. Kusunoki, I. Kanazawa, S. Tsuji, Dorsal root ganglia-specific expression of the beta-galactoside alpha 1,2-fucosyltransferase genes in rabbits, J Neurochem, 1998, 70, 2174–8.
- S. Hitoshi, N. Koijima, S. Kusunoki, J. Inokuchi, I. Kanazawa, S. Tsuji, Expression of the beta-galactoside alpha 1,2-fucosyltransferase gene suppresses axonal outgrowth of neuro 2a neuroblastoma cells, J Neurochem, 1996, 66, 1633–40.
- C. G. Chen, E. J. Salvaris, M. Romanella, A. Aminian, M. Katerelos, N. Fisicaro, A. J. d'Apice, M. J. Pearse, Transgenic expression of human alpha 1,2-fucosyltransferase (Htransferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection, Transplantation, 1998, 65, 832–7.
- S. D. Rosen, C. R. Bertozzi, The selectins and their ligands, Curr Opin Cell Biol, 1994, 6, 663–73.
- E. Grabenhorst, M. Nimtz, J. Costa, H. S. Conradt, In vivo specificity of human alpha 1,3/4-fucosyltransferases III–VII in the biosynthesis of LewisX and sialyl LewisX motifs on complextype N-glycans. Coexpression studies from Bhk-21 cells together with human beta-trace protein, J Biol Chem, 1998, 273, 30985–94.
- J. Costa, E. Grabenhorst, M. Nimtz, H. S. Conradt, Stable expression of the Golgi form and secretory variants of human fucosyltransferase III from BHK-21 cells. Purification and characterization of an engineered truncated form from the culture medium, J. Biol Chem, 1997, 272, 11613–21.
- N. Yamada, Y. S. Chung, S. Takatsuka, Y. Arimoto, T. Sawada, T. Dohi, M. Sowa, Increased sialyl Lewis A expression and fucosyltransferase activity with acquisition of a high metastatic capacity in a colon cancer cell line, Br J Cancer, 1997, 76, 582–7.
- A. G. Klopocki, A. Laskowska, J. Antoniewicz-Papis, M. Duk, E. Lisowska, M. Ugorski, Role of sialosyl Lewis(a) in adhesion of colon cancer cells—the antisense RNA approach, Eur J Biochem, 1998, 253, 309–18.
- M. Martin-Satue, R. Marrugat, J. A. Cancelas, J. Blanco, Enhanced expression of alpha(1,3)fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells, Cancer Res, (1998), 58, 1544–50.
- T. Hada, K. Fukui, M. Ohno, S. Akamatsu, S. Yazawa, K. Enomoto, K. Yamaguchi, Y. Matsuda, Y. Amuro, N. Yamanaka, Increased plasma alpha (1→3)-L-fucosyltransferase activities in patients with hepatocellular carcinoma, Glycoconj J, (1995) 12, 627–31.
- S. E. Goelz, C. Hession, D. Goff, B. Griffiths, R. Tizard, B. Newman, G. Chi-Rosso, R. Lobb, ELFT: a gene that directs the expression of an ELAM-1 ligand, Cell, 1990, 63, 1349–56.
- R. Kumar, B. Potvin, W. A. Muller, P. Stanley, Cloning of a human alpha(1,3)-fucosyl-transferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants, J Biol Chem, 1991, 266, 21777–83.
- N. Le Marer, M. M. Palcic, J. L. Clarke, D. Davies, P. O. Skacel, Developmental regulation of alpha 1,3–fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow, Glycobiology, 1997, 7, 357–65.
- J. L. Clarke, W. Watkins, Alpha 1,3-L-fucosyltransferase expression in developing human myeloid cells. Antigenic, enzymatic, and mRNA analyses, J Biol Chem, 1996, 271, 10317–28.
- J. Ogawa, H. Inoue, S. Koide, Expression of alpha-1,3–fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer, Cancer Res, 1996, 56, 325–9.
- P. Cullen, S. Mohr, B. Brennhausen, A. Cignarella, G. Assmann, Downregulation of the selectin ligand-producing fucosyltransferases FucTIV and Fuc-TVII during foam cell formation in monocyte-derived macrophages, Arterioscler Thromb Vase Biol, 1997, 17, 1591–8.
- P. Maly, A. Thall, B. Petryniak, C. E. Rogers, P. L. Smith, R. M. Marks, R. J. Kelly, K. M. Gersten, G. Cheng, T. L. Saunders, S. A. Camper, R. T. Camphausen, F. X. Sullivan, Y. Isogai, O. Hindsgaul, U. H. von Andrian, J. B. Lowe, The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis, Cell, 1996, 86, 643–53.
- R. N. Knibbs, R. A. Craig, P. Maly, P. L. Smith, F. M. Wolber, N. E. Faulkner, J. B. Lowe, L. M. Stoolman, Alpha(1,3)-fucosyltransferase VH-dependent synthesis of Pand Eselectin ligands on cultured T lymphoblasts, J Immunol, 1998, 161, 6305–15.
- C. A. van Wely, A. D. Blanchard, C. J. Britten, Differential expression of alpha3 fucosyl-transferases in Thl and Th2 cells correlates with their ability to bind P-selectin, Biochem Biophys Res Commun, 1998, 247, 307–11.
- A. J. Wagers, C. M. Waters, L. M. Stoolman, G. S. Kansas, Interleukin 12 and interleukin 4 control T cell adhesion to endothelial selectins through opposite effects on alpha 1,3-fucosyl-transferase VII gene expression, J. Exp Med, 1998, 188, 2225–2231.
- Z. Ge, N. W. Chan, M. M. Palcic, D. E. Taylor, Cloning and heterologous expression of an alpha 1,3-fucosyltransferase gene from the gastric pathogen Helicobacter pylori, J Biol Chem, 1997, 272, 21357–63.
- S. L. Martin, M. R. Edbrooke, T. C. Hodgman, D. H. van den Eijnden, M. I. Bird, Lewis X biosynthesis in Helicobacter pylori. Molecular cloning of an alpha(1,3)-fucosyltransferase gene, J Biol Chem, 1997, 272, 21349–56.
- N. Uozumi, S. Yanagidani, E. Miyoshi, Y. Ihara, T. Sakuma, C. X. Gao, T. Teshima, S. Fujii, T. Shiba, N. Taniguchi, Purification and cDNA cloning of porcine brain GDP-L-Fuc:N-acctyl-beta-D-glucosaminide alpha 1→6 fucosyltransferase, J Biol Chem, 1996, 271, 27810–7.
- Y. Wang, M. W. Spellman, Purification and characterization of a GDP-fucose:polypeptide fucosyltransferase from Chinese hamster ovary cells, J Biol Chem, 1998, 273, 8112–8.
- G. Srikrishna, L. Wang, H. H. Freeze, Fucosebeta-1–P-Ser is a new type of glycosylation: using antibodies to identify a novel structure in Dictyostelium discoideum and study multiple types of fucosylation during growth and development, Glycobiology, 1998, 8, 799–811.
- P. Teng-umnuay, H. R. Morris, A. Dell, M. Panico, T. Paxton, C. M. West, The cytoplasmic F-box binding protein SKP1 contains a novel pentasaccharide linked to hydroxyproline in Dictyostelium, J Biol Chem, 1998, 273, 18242–9.