This chapter contains sections titled:

• Introduction

  • HUPO Plasma Proteome Project pilot phase

  • Need for novel insights into cardiovascular disease

• Materials and methods

• Groups of cardiovascular-related proteins

  • Markers of inflammation and CVD

  • Vascular and coagulation proteins

  • Signaling proteins

  • Growth- and differentiation-associated proteins

  • Cytoskeletal proteins

  • Transcription factors

  • Channel and receptor proteins

  • Heart failure- and remodeling-related proteins

• Functional analyses and implications

  • Organ specific cardiovascular-related proteins in plasma

  • Novel cardiovascular-related proteins identified in plasma

• Methodology considerations

• Conclusions and future directions

• References