Clinical Epidemiological and Statistical Challenges in Defining, Recording and Analysing Endpoints

Thorkild Ia Sørensen MD,

Thorkild Ia Sørensen MD

Professor

Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Per Kragh Andersen PhD, MSC,

Per Kragh Andersen PhD, MSC

Professor

Department of Biostatistics, Institute of Public Health, University of Copenhagen, Denmark

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Thorkild Ia Sørensen MD,

Thorkild Ia Sørensen MD

Professor

Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark

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Per Kragh Andersen PhD, MSC,

Per Kragh Andersen PhD, MSC

Professor

Department of Biostatistics, Institute of Public Health, University of Copenhagen, Denmark

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Book Editor(s):Roberto de Franchis MD, AGAF,

Roberto de Franchis MD, AGAF

Professor of Gastroenterology Head

Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy

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First published: 17 November 2010

https://doi.org/10.1002/9781444393989.ch5

Citations: 1

Summary

This chapter contains sections titled:

Introduction
Clinical course in patients with portal hypertension
Clinical epidemiology deals with these problems
Statistical tools
Definition and recording of endpoints
Definition of observation time
Surrogate endpoints
Combined endpoints
Competing endpoints
Changes over time in risk
Correlated endpoints
Repeated endpoints and multistate models
References

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Citing Literature

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition