Treatment of Acute Bleeding
Treatment of the Acute Bleeding Episode
Loren Laine MD
Professor
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Search for more papers by this authorShahab Abid MD, MBBS, FCPS, FRCP (Edin.), FACG
Associate Professor
Department of Gastroenterology, Aga Khan University Hospital, Karachi, Pakistan
Search for more papers by this authorAgustin Albillos MD
Department of Gastroenterology, Hospital Ramon y Cajal, University of Alcalà, Madrid, Spain
Search for more papers by this authorPatrick S Kamath MD
Professor
Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorJean-Pierre Vinel MD
Professor Head
University Hospital Toulouse-Purpan, and Inserm U858, Toulouse, France
Search for more papers by this authorJuan Carlos García-Pagán MD, PhD
Consultant
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Spain
Search for more papers by this authorLoren Laine MD
Professor
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Search for more papers by this authorShahab Abid MD, MBBS, FCPS, FRCP (Edin.), FACG
Associate Professor
Department of Gastroenterology, Aga Khan University Hospital, Karachi, Pakistan
Search for more papers by this authorAgustin Albillos MD
Department of Gastroenterology, Hospital Ramon y Cajal, University of Alcalà, Madrid, Spain
Search for more papers by this authorPatrick S Kamath MD
Professor
Mayo Clinic College of Medicine, Rochester, MN, USA
Search for more papers by this authorJean-Pierre Vinel MD
Professor Head
University Hospital Toulouse-Purpan, and Inserm U858, Toulouse, France
Search for more papers by this authorJuan Carlos García-Pagán MD, PhD
Consultant
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Spain
Search for more papers by this authorRoberto de Franchis MD, AGAF
Professor of Gastroenterology Head
Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy
Search for more papers by this authorSummary
This chapter contains sections titled:
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Introduction
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General management
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Primary therapy for acute variceal bleeding
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Rescue therapy for acute treatment failure
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References
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Blood volume restitution
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Antibiotic prophylaxis
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Prevention of hepatic encephalopathy
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Assessment of prognosis
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Timing of endoscopy
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Pharmacological treatment
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Endoscopic treatment
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Early TIPS placement
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Use of balloon tamponade
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Use of self-expandable metal stents
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Management of treatment failures
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Areas requiring further study
References
- Castañeda B, Debernardi-Venon W, Bandi JC, et al. (2000) The role of portal pressure in the severity of bleeding in portal hypertensive rats. Hepatology 31: 581–6.
- Kravetz D, Sikuler E, Groszmann RJ (1986) Splanchnic and systemic hemo-dynamics in portal hypertensive rats during hemorrhage and blood volume restitution. Gastroenterology 90: 1232–40.
- Colomo A, Hernández-Gea V, Muñiz-Díaz E, et al. (2008) Transfusion strategies in patients with cirrhosis and acute gastrointestinal bleeding. Hepatology 48: 413A.
- Bashour FN, Teran JC, Mullen KD, et al. (2000) Prevalence of peripheral blood cytopenias (hypersplenism) in patients with nonalcoholic chronic liver disease. Am J Gastroenterol 95: 2936–9.
- Tripodi A, Primignani M, Chantarangkul V, et al. (2006) Thrombin generation in patients with cirrhosis: the role of platelets. Hepatology 44: 440–5.
- Tripodi A, Primignani M, Chantarangkul V, et al. (2009) An imbalance of provs. anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology 137: 2105–11.
- Youssef WI, Salazar F, Dasarathy S, Beddow T, Mullen KD. (2003) Role of fresh frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study. Am J Gastroenterol 98: 1391–4.
- Bosch J, Thabut D, Albillos A, et al. (2008) Recombinant factor VIIa for variceal bleeding in patients with advanced cirrhosis: A randomized, controlled trial. Hepatology 47: 1604–14.
- Soares-Weiser K, Brezis M, Tur-Kaspa R, Leibovici L (2002) Antibiotic prophylaxis for cirrhotic patients with gastrointestinal bleeding. Cochrane Database Syst Rev, CD002907.
- Garcia-Tsao G (2004) Treatment of acute variceal bleeding: general management and prevention of infections. In: Groszmann RJ, Bosch J (eds) Portal Hypertension in the 21st Century. Kluwer Academic Publishers: Dordrecht, pp. 233–40.
- Fernández J, Navasa M, Gómez J, et al. (2002) Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis. Hepatology 35: 140–8.
- Fernández J, Ruiz-del-Arbol L, Gómez C, et al. (2006) Norfloxacin vs. ceftriaxone in the prophylaxis of infections in patients with advanced cirrhosis and hemorrhage. Gastroenterology 131: 1049–56.
- Luca A, Feu F, García-Pagán JC, et al. (1994) Favorable effects of total paracentesis on splanchnic haemodynamics in cirrhotic patients with tense ascites. Hepatology 20: 30–3.
- Ginès A, Fernández-Esparrach G, Monescillo A, et al. (1996) Randomized trial comparing albumin, dextran 70, and polygeline in cirrhotic patients with ascites treated by paracentesis. Gastroenterology 111: 1002–10.
- Abraldes JG, Villanueva C, Bañares R, et al. (2008) Hepatic venous pressure gradient and prognosis in patients with acute variceal bleeding treated with pharmacologic and endoscopic therapy. JHepatol 48: 229–36.
- Gatta A, Merkel C, Amodio P, et al. (1994) Development and validation of a prognostic index predicting death after upper gastrointestinal bleeding in patients with liver cirrhosis: a multicenter study. Am J Gastroenterol 89: 1528–36.
- Ben Ari Z, Cardin F, McCormick AP, Wannamethee G, Burroughs AK (1999) A predictive model for failure to control bleeding during acute variceal haemorrhage. JHepatol 31: 443–50.
- Moitinho E, Escorsell A, Bandi JC, et al. (1999) Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology 117: 626–31.
- D'Amico G, de Franchis R (2003) Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 38: 599–612.
- Villanueva C, Ortiz J, Minana J, et al. (2001) Somatostatin treatment and risk stratification by continuous portal pressure monitoring during acute variceal bleeding. Gastroenterology 121: 110–17.
- Cardenas A, Gines P, Uriz J, et al. (2001) Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis. Hepatology 34: 671–6.
- Monescillo A, Martinez-Lagares F, Ruiz-del-Arbol L, et al. (2004) Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding. Hepatology 40: 793–801.
- Avgerinos A, Armonis A, Stefanidis G, et al. (2004) Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis. Hepatology 39: 1623–30.
- Laine L, Planas R, Nevens F, et al. (2006) Treatment of the acute bleeding episode. In: de Franchis R (ed.) Portal Hypertension IV. Proceedings of the Fourth Baveno International Consensus Workshop on Methodology of Diagnosis and Treatment. Blackwell Publishing: Oxford, pp. 217–42.
- Avgerinos A, Armonis A (1994) Balloon tamponade technique and efficacy in variceal haemorrhage. Scand J Gastroenterol 29 (Suppl 207): 11–16.
- Walker S, Stiehl A, Raedsch R, Kommerell B (1986) Terlipressin in bleeding esophageal varices: a placebo-controlled, double-blind study. Hepatology 6: 112–15.
- Freeman JG, Cobden I, Record CO (1989) Placebo-controlled trial of terlipressin (glypressin) in the management of acute variceal bleeding. J Clin Gastroenterol 11: 58–60.
- Soderlund C, Magnusson I, Torngren S, Lundell L (1990) Terlipressin (triglycyl-lysine vasopressin) controls acute bleeding oesophageal varices. A double-blind, randomized, placebo-controlled trial. Scand J Gastroenterol 25: 622–30.
- Levacher S, Letoumelin P, Pateron D, et al. (1995) Early administration of terlipressin plus glyceryl trinitrate to control active upper gastrointestinal bleeding in cirrhotic patients. Lancet 346: 865–8.
- D'Amico G, Pagliaro L, Bosch J (1999) Pharmacological treatment of portal hypertension: an evidence-based approach. Sem Liv Dis 19: 475–505.
- Gøtzsche PC, Hróbjartsson A (2008) Somatostatin analogues for acute bleeding oesophageal varices. Cochrane Database Syst Rev (3): CD000193. DOI: 10.1002/14651858.CD000193.pub3.
- Burroughs AK, McCormick PA, Hughes MD, et al. (1990) Randomized, double-blind, placebo controlled trial of somatostatin for variceal bleeding. Emergency control and prevention of early rebleeding. Gastroenterology 99: 1388–95.
- Valenzuela JE, Schubert T, Fogel MR, et al. (1989) A multicenter, randomized, double-blind trial of somatostatin in the management of acute hemorrhage from esophageal varices. Hepatology 10: 958–61.
- Burroughs AK (1996) Double blind RCT of 5 day octreotide versus placebo, associated with sclerotherapy for trial/failures. Hepatology 24: 352A.
- Moitinho E, Planas R, Bañares R, et al., Variceal Bleeding Study Group (2001) Multicenter randomized controlled trial comparing different schedules of somatostatin in the treatment of acute variceal bleeding. J Hepatol 35: 712–18.
- Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD (2007) Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am JGastroenterol 102: 2086–102.
- Avgerinos A, Nevens F, Raptis S, Fevery J (1997) Early administration of somatostatin and efficacy of sclerotherapy in acute oesophageal variceal bleeds: the European Acute Bleeding Oesophageal Variceal Episodes (ABOVE) randomised trial. Lancet 350: 1495–9.
- Calès P, Masliah C, Bernard B, et al. (2001) Early administration of vapreotide for variceal bleeding in patients with cirrhosis. NEnglJMed 344: 23–8.
- Barkun A, Bardou M, Kuipers C, et al. (2010) International consensus recommendations on the management of patients with non-variceal upper gastrointestinal bleeding. Ann Intern Med 152: 101–13.
- Cheung J, Soo I, Bastiampillai R, Zhu Q, Ma M (2009) Urgent vs. non-urgent endoscopy in stable acute variceal bleeding. Am J Gastroenterol 104: 1125–9.
- Lo GH, Lai KH, Cheng JS, et al. (1997) Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 25: 1101–4.
- Villanueva C, Piqueras M, Aracil C, et al. (2006) A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. J Hepatol 45: 560–7.
- Lo GH, Lai KH, Cheng JS, Chen MH, Chiang HT (2001) A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices. Hepatology 33: 1060–4.
- Tan PC, Hou MC, Lin HC, et al. (2006) A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology 43: 690–7.
- Rengstorff DS, Binmoeller KF (2004) A pilot study of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices in humans. Gastrointest Endosc 59: 553–8.
- D'Amico G, Pietrosi G, Tarantino I, Pagliaro L (2003) Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: A Cochrane meta-analysis. Gastroenterology 124: 1277–91.
- Chen WC, Lo GH, Tsai WL, et al. (2006) Emergency endoscopic variceal ligation versus somatostatin for acute esophageal variceal bleeding. J Chinese Med Assoc 69: 55–7.
- Villaneueva C, Ortiz J, Sabat M, et al. (1999) Somatostatin alone or combined with emergency sclerotherapy in the treatment of acute esophageal variceal bleeding: a prospective randomized trial. Hepatology 30: 384–9.
- Lo GH, Chen WC, Wang HM, et al. (2009) Low-dose terlipressin plus banding ligation versus low-dose terlipressin alone in the prevention of very early rebleeding of oesophageal varices. Gut 58: 1275–80.
- Besson I, Ingrand P, Person B, et al. (1995) Sclerotherapy with or without octreotide for acute variceal bleeding. NEnglJMed 333: 555–60.
- Zuberi BF, Baloch Q (2000) Comparison of endoscopic variceal sclerotherapy alone and in combination with octreotide in controlling acute variceal hemorrhage and early rebleeding in patients with low-risk cirrhosis. Am J Gastroenterol 95: 768–71.
- Freitas SD, Sofia C, Pontes JM, et al. (2000) Octreotide in acute bleeding esophageal varices: a prospective randomized study. Hepatogastroenterology 47: 1310–14.
- Shah HA, Mumtaz K, Jafri W, et al. (2005) Sclerotherapy plus octreotide versus sclerotherapy alone in the management of gastro-oesophageal variceal hemorrhage. J Ayub Med Coll Abbottabad 17: 10–14.
- Triantos CK, Patch D, Papatheodordis GV, et al. (2006) An evaluation of emergency sclerotherapy of varices in randomized trials: looking the needle in the eye. Endoscopy 38: E74–90.
- Sung JJY, Chung SCS, Yung MY, et al. (1995) Prospective randomised study of effect of octreotide on rebleeding from oesophageal varices after endoscopic ligation. Lancet 346: 1666–9.
- Sarin SK, Kumar A, Jha SK, Sharma P, Sharma B (2008) Combination of somatostatin plus endoscopic variceal ligation (EVL) is similar to EVL alone in control of acute variceal bleeding: a randomized controlled trial. Hepatology 48 (Suppl): 628A.
- García-Pagán JC, Caca K, Bureau C, et al. (2010) Early use of TIPS in patients with cirrhosis and variceal bleeding. NEnglJMed 362: 2370–9.
- Orloff MJ, Isenberg JI, Wheeler HO, et al. (2009) Randomized trial of emergency endoscopic sclerotherapy versus emergency portacaval shunt for acutely bleeding esophageal varices in cirrhosis. J Am Coll Surg 209: 25–40.
- Zehetner J, Shamiyeh A, Wayand W, Hubmann R (2008) Results of a new method to stop acute bleeding from esophageal varices: implantation of a self-expanding stent. Surg Endosc 22: 2149–52.
- Wright G, Lewis H, Hogan B, et al. (2010) A self-expanding metal stent for complicated variceal hemorrhage: experience at a single center. Gastrointest Endosc 71: 71–8.
- Henderson JM, Boyer TD, Kutner MH, et al. (2006) Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial. Gastroenterology 130: 1643–51.
- Bureau C, García-Pagán JC, Layrargues GP, et al. (2007) Patency of stents covered with polytetrafluoroethylene in patients treated by transjugular intrahepatic portosystemic shunts: long-term results of a randomized multicentre study. Liver Int 27: 742–74.