The industries are highly focused on fabricating high-quality products and are always looking for a concept that maintains the rate of mass and specially heat transfer. Managing heat transfer is getting more attention because of the use of nanofluids instead of any other usual fluid. Nanofluids with motile microbial processes are studied critically due to their better control of mass and heat transfer. This article studies the effect of microbial activity with solutal and thermal Brownian motion in the bioconvection nanofluid past a stretching surface. The partial differential equations governing the flow are metamorphosed into a set of ordinary differential equations using similarity variables and are finally solved by utilizing the well-known spectral quasilinearization strategy (SQLM). The impact of various parameters is further discussed using diagrams that are very much in favor of our assumed model. Our study is mainly focused on the effect of the velocity slip on thermal, solutal, and microbial Biot number for the bioconvection boundary layer nanofluid flow comprehending micro-organisms above a stretching surface.