Activation of drug structure at the nanometer level can prolong drug loading time, increase drug biotransport, and increase drug uniformity, thereby reducing drug toxicity and improving efficacy. Consequently, nanostep structures for drug delivery in the clinical discipline have attracted increasing interest, which has generated tremendous momentum just like ordinary pharmaceutical companies, biomedical and pharmaceutical companies have invested a great deal of money, energy and time in researching effective nanocarriers structure, 2D substances are of great interest because of their unique residence times in physical and chemical environments and their broad potential for applications in devices, biosensing, medicine, energy, and catalysis. The two multidimensional substances also have excellent drug delivery abilities compared to the conventional drug delivery structures. The main function of the 2D substance is the ultrafine nanogrid structure intentionally attached to the specific massive area of the ground thick structure for various external stimuli, 2D substances can exist as extremely green photodynamic and photothermal remedies for ailments. In addition, two-dimensional nanomaterial layer systems offer immense space for highly ecological medicines. Meanwhile, 2D substances with 2D terrain-changing material can have vivid orientation. Drugs can be properly stacked, and the effects of drugs can be reduced. However, NIR reaction, pH reaction with two-dimensional substances, two-dimensional SDDS can properly dispense tablets and effectively control blood consciousness to achieve great healing potential. These residences offer the possibility of multimodal healing of the disease. These special blessings are making 2D substance research more popular in the SDDS. However, it needs to be done much faster than can be accomplished in scientific exercises, but there are pressing issues that need to be addressed, including the transient long-term degradability and long-term toxicity of 2D materials. In addition, they study 2D substances in vitro , which are reserved for terrestrial animals, and in vitro experiments are also an important step towards their scientific implementation. Further intensive research and further in vivo experiments are expected to eventually implement SDDS-derived 2D coated compound packages as part of a scientific exercise. In this chapter we highlight the recent SDDS improvements, which are huge a wide range of 2D sensitive substance companies consisting of micelles, polymers, liposomes, hydrogels, nanofilms, nanoparticles, etc . Large organic packaging of 2D substances in 2D substances modified to be pharmaceutical companies function. 2D Stuff because pharmaceutical companies can improve disease drug treatment outcomes through managed launch, sustained launch, and stepped forward drug targeting. Therefore, 2D substances are perfectly suited to enhance the following SDDS technology.