EMS clinicians manage and assess pregnant patients frequently. The anatomic and physiologic changes of pregnancy must be understood to provide appropriate evaluation, treatment, and transport. Initial evaluation and stabilization of critically ill or injured pregnant patients includes management of airway, breathing, and circulation. The chapter examines key management considerations in areas including cardiovascular, respiratory, gastrointestinal, endocrine, hematology, genitourinary/renal, neurology, and toxicology, all of which require specific knowledge to provide the best medical care.