Uncontrolled hemorrhage is a leading cause of potentially preventable death in trauma in both civilian and military settings. Assessment and evaluation of hemorrhagic shock include vital signs and calculated values such as shock index. Treatment modalities for hemorrhage control include direct pressure, tourniquets (extremity, abdominal, and junctional), external compression, splinting, and aortic balloon occlusion. Advanced hemostatic agents include chitosan, kaolin, and fibrin-based dressings. A discussion of adjunctive therapies includes permissive hypotension, hypothermia prevention, prehospital blood product transfusion, and use of medications such as recombinant factor VIIa and tranexamic acid.