Technologies of Microalgae Biomass Cultivation for Bio-Fuel Production
Challenges and Benefits
Trinath Biswal
Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Odisha, India
Search for more papers by this authorKrushna Prasad Shadangi
Department of Chemical Engineering, Veer Surendra Sai University of Technology, Burla, Odisha, India
Search for more papers by this authorPrakash Kumar Sarangi
College of Agriculture, Central Agricultural University, Imphal, Manipur, India
Search for more papers by this authorTrinath Biswal
Department of Chemistry, Veer Surendra Sai University of Technology, Burla, Odisha, India
Search for more papers by this authorKrushna Prasad Shadangi
Department of Chemical Engineering, Veer Surendra Sai University of Technology, Burla, Odisha, India
Search for more papers by this authorPrakash Kumar Sarangi
College of Agriculture, Central Agricultural University, Imphal, Manipur, India
Search for more papers by this authorPrakash Kumar Sarangi
Search for more papers by this authorSummary
The utilization of fossil fuel contributes a significant fraction of greenhouse gas to the troposphere. Now, rigorous research initiatives are carried out to find out the alternative sources to fossil fuels, which will be sustainable and can be commercialized to meet the market demand. In this situation, the biofuel obtained from renewable sources is the only alternative in global economy from a sustainable point of view. The biofuel cannot be produced from crop grains as it may create a scarcity of food worldwide. The biofuel derived from algae is a proper alternative to fossil fuels, however the technology adopted must be modified in order to overcome the demerits associated with it to compete with the fuel market. This chapter elaborates on the details of the algae cultivation methodology, benefits of the use of algae as a source of biofuel production, challenges associated with it, and the impact of microalgae on the environment.
References
- Gupta , P. L. , Lee , S.-M. , & Choi , H.-J. A mini review: photobioreactors for large scale algal cultivation . World Journal of Microbiology and Biotechnology , 31 ( 9 ), 1409 – 1417 ( 2015 ). doi: 10.1007/s11274-015-1892-4
- Onar , O. C. , & Khaligh , A. Energy Sources. Alternative Energy in Power Electronics , 81 – 154 ( 2015 ). doi: 10.1016/b978-0-12-416714-8.00002-0
- Abas , N. , Kalair , A. , & Khan , N. Review of fossil fuels and future energy technologies . Futures , 69 , 31 – 49 ( 2015 ). doi: 10.1016/j.futures.2015.03.003
-
Alalwana , H. A.
,
Alminshid A. H.
and
Aljaafaric , H. A.S.
Promising evolution of biofuel generations
.
Subject review. Renewable Energy Focus
28
,
127
-
139
(
2019
). https://doi.org/
10.1016/j.ref.2018.12.006
10.1016/j.ref.2018.12.006 Google Scholar
- Alam , F. , Mobin , S. and Chowdhury , H. Third generation biofuel from Algae . Procedia Engineering 105 , 763 - 768 ( 2015 ).
-
Sadatshojaei , E.
,
Wood , D.A.
,
Mowla , D.
Third Generation of Biofuels Exploiting Microalgae
. In:
Inamuddin
,
A. Asiri
(eds)
Sustainable Green Chemical Processes and their Allied Applications. Nanotechnology in the Life Sciences
.
Springer
,
Cham
.
575
-
588
(
2020
). https://doi.org/
10.1007/978-3-030-42284-4_21
10.1007/978?3?030?42284?4_21 Google Scholar
- Mohr , A. ,& Raman , S. Lessons from first generation biofuels and implications for the sustainability appraisal of second generation biofuels . Energy Policy , 63 , 114 – 122 . ( 2013 ) doi: 10.1016/j.enpol.2013.08.033
- Enamala , M. K. , Enamala , S. , Chavali , M. , Donepudi , J. , Yadavalli , R. , Kolapalli , B. , Kuppam , C. Production of biofuels from microalgae - A review on cultivation, harvesting, lipid extraction, and numerous applications of microalgae . Renewable and Sustainable Energy Reviews , 94 , 49 – 68 ( 2018 ). doi: 10.1016/j.rser.2018.05.012
- Yin , Z. , Zhu , L. , Li , S. , Hu , T. , Chu , R. , Mo , F. , Li , B. A comprehensive review on cultivation and harvesting of microalgae for biodiesel production: environmental pollution control and future directions . Bioresource Technology , 301 , 1 - 19 ( 2020 ). 122804. doi: 10.1016/j.biortech.2020.122804
-
Ganesan , R.
,
Manigandan , S.
,
Samuel , M. S.
,
Shanmuganathan , R.
,
Brindhadevi , K.
,
Lan Chi , N. T.
Pugazhendhi , A.
A review on prospective production of biofuel from microalgae
.
Biotechnology Reports
,
27
,
1
-
13
(
2020
),e00509.
10.1016/j.btre.2020.e00509 Google Scholar
- Thiruvenkadam , S. , Izhar , S. , Yoshida , H. , Danquah , M. K. , & Harun , R. Process application of Subcritical Water Extraction (SWE) for algal bio-products and biofuels production . Applied Energy , 154 , 815 – 828 ( 2015 ).
- Hannon , M. , Gimpel , J. , Tran , M. , Rasala , B. and Mayfield , S. Biofuels from algae: challenges and potential , Biofuels. 1 ( 5 ): 763 – 784 ( 2010 ).
-
Khan , S.
,
Siddique , R.
,
Sajjad , W.
,
Nabi , G.
,
Hayat , K. M.
,
Duan , P.
, &
Yao , L.
Biodiesel Production From Algae to Overcome the Energy Crisis
.
HAYATI Journal of Biosciences
,
24
(
4
),
163
–
167
(
2017
). doi:
10.1016/j.hjb.2017.10.003
10.1016/j.hjb.2017.10.003 Google Scholar
- Leite , G. B. , Abdelaziz , A. E. M. , & Hallenbeck , P. C. Algal biofuels: Challenges and opportunities . Bioresource Technology , 145 , 134 – 141 ( 2013 ).
- Osanai , T. , Park , Y.-I. , & Nakamura , Y. Editorial: Biotechnology of Microalgae, Based on Molecular Biology and Biochemistry of Eukaryotic Algae and Cyanobacteria . Frontiers in Microbiology , 8 , 118 - 121 ( 2017 ).
- Demoulin , C. F. , Lara , Y. J. , Cornet , L. , François , C. , Baurain , D. , Wilmotte , A. , & Javaux , E. J. Cyanobacteria evolution: Insight from the fossil record . Free Radical Biology and Medicine. 140 , 206 - 223 ( 2019 ).
- Bhateria , R. , & Dhaka , R. Algae as biofuel . Biofuels , 5 ( 6 ), 607 – 631 ( 2014 ). doi: 10.1080/17597269.2014.1003701
-
Saad , A.
, and
Atia , A.
,
Review on Freshwater Blue-Green Algae (Cyanobacteria): Occurrence, Classification and Toxicology
,
Biosciences Biotechnology Research Asia.
11
(
3
),
1319
-
1325
(
2014
).
10.13005/bbra/1522 Google Scholar
- Sathasivam , R. , Radhakrishnan , R. , Hashem , A. , & AbdAllah , E. F. , Microalgae metabolites: A rich source for food and medicine . Saudi Journal of Biological Sciences. 26 ( 4 ), 709 - 722 ( 2019 ). doi: 10.1016/j.sjbs.2017.11.003
-
Perrine , Z.
,
Negi , S.
, &
Sayre , R. T.
Optimization of photosynthetic light energy utilization by microalgae
.
Algal Research
,
1
(
2
),
134
–
142
(
2012
).
10.1016/j.algal.2012.07.002 Google Scholar
- Abdel-Raouf , N. , Al-Homaidan , A. A. , & Ibraheem , I. B. M. Microalgae and wastewater treatment . Saudi Journal of Biological Sciences , 19 ( 3 ), 257 – 275 ( 2012 ). doi: 10.1016/j.sjbs.2012.04.005
- Alam , F , Datea , A ., Rasjidina , R ., Mobinb , S ., Moriaa , H ., Biofuel from algae-Is it a viable alternative? Procedia Engineering 49 , 221 - 227 ( 2012 ).
- Deshmukh , S. , Kumar , R. , & Bala , K. , Microalgae biodiesel: A review on oil extraction, fatty acid composition, properties and effect on engine performance and emissions . Fuel Processing Technology , 191 , 232 – 247 ( 2019 ).
- Xue , Z. , Yu , Y. , Yu , W. , Gao , X. , Zhang , Y. , & Kou , X. , Development Prospect and Preparation Technology of Edible Oil From Microalgae . Frontiers in Marine Science , 7 . 402 - 416 ( 2020 ). doi: 10.3389/fmars.2020.00402
-
Hassan , M. H.
, &
Kalam , M. A.
An Overview of Biofuel as a Renewable Energy Source: Development and Challenges
.
Procedia Engineering
,
56
,
39
–
53
(
2013
). doi:
10.1016/j.proeng.2013.03.087
10.1016/j.proeng.2013.03.087 Google Scholar
- Jalilian , N. , Najafpour , G. D. , & Khajouei , M. , Macro and Micro Algae in Pollution Control and Biofuel Production – A Review . ChemBioEng Reviews. 7 , 1 - 17 ( 2020 ). doi: 10.1002/cben.201900014
- Hoyer , J. , Cotta , F. , Diete , A. , & Großmann , J. Bioenergy from Microalgae -Vision or Reality? ChemBioEng Reviews , 5 ( 4 ), 207 – 216 ( 2018 ).
- Correa , D. F. , Beyer , H. L. , Fargione , J. E. , Hill , J. D. , Possingham , H. P. , Thomas-Hall , S. R. , & Schenk , P. M. Towards the implementation of sustainable biofuel production systems . Renewable and Sustainable Energy Reviews , 107 , 250 - 263 ( 2019 ). https://doi.org/ 10.1016/j.rser.2019.03.005
- Rodionova , M. V. , Poudyal , R. S. , Tiwari , I. , Voloshin , R. A. , Zharmukhamedov , S. K. , Nam , H. G. , Allakhverdiev , S. I. , Biofuel production: Challenges and opportunities . International Journal of Hydrogen Energy , 42 ( 12 ), 8450 – 8461 ( 2017 ). doi: 10.1016/j.ijhydene.2016.11.125
- Shuba , E. S. , & Kifle , D. , Microalgae to biofuels: “Promising” alternative and renewable energy, review . Renewable and Sustainable Energy Reviews , 81 , 743 – 755 ( 2018 ). doi: 10.1016/j.rser.2017.08.042
- Raheem , A. , Prinsen , P. , Vuppaladadiyam , A. K. , Zhao , M. , & Luque , R. A review on sustainable microalgae based biofuel and bioenergy production: Recent developments . Journal of Cleaner Production , 181 , 42 – 59 ( 2018 ).
- Abo , B. O. , Odey , E. A. , Bakayoko , M. , & Kalakodio , L. Microalgae to biofuels production: a review on cultivation, application and renewable energy . Reviews on Environmental Health , 34 ( 1 ), 1 - 9 ( 2019 ) doi: 10.1515/reveh-2018-0052
- Saad , M. G. , Dosoky , N. S. , Zoromba , M. S. , & Shafik , H. M. , Algal Biofuels: Current Status and Key Challenges . Energies , 12 ( 10 ), 1920 - 1941 ( 2019 ).
- Voloshin , R. A. , Rodionova , M. V. , Zharmukhamedov , S. K. , Nejat Veziroglu , T. , & Allakhverdiev , S. I. Review: Biofuel production from plant and algal biomass . International Journal of Hydrogen Energy , 41 ( 39 ), 17257 – 17273 ( 2016 ). doi: 10.1016/j.ijhydene.2016.07.084
- Makareviciene , V. , Skorupskaite , V. & Andruleviciute , V. Biodiesel fuel from microalgae-promising alternative fuel for the future: a review . Rev Environ Sci Biotechnol 12 , 119 – 130 ( 2013 ). https://doi.org/ 10.1007/s11157-013-9312-4
- Singh , N. K. , & Dhar , D. W. , Microalgae as second generation biofuel. A review . Agronomy for Sustainable Development , 31 ( 4 ), 605 – 629 ( 2011 ). doi: 10.1007/s13593-011-0018-0
- Brennan , L. , & Owende , P. Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products . Renewable and Sustainable Energy Reviews , 14 ( 2 ), 557 – 577 ( 2010 ). doi: 10.1016/j.rser.2009.10.009
-
Dębowski , M.
,
Zieliński , M.
, &
Dudek , M.
Concept of a Technological System for Microalgae Biomass Production with the Use of Effluents from Fermentation Tanks
.
Energy Procedia
,
105
,
681
–
687
(
2017
). doi:
10.1016/j.egypro.2017.03.375
10.1016/j.egypro.2017.03.375 Google Scholar
- Falciatore , A. , Jaubert , M. , Bouly , J.-P. , Bailleul , B. , & Mock , T. Diatom Molecular Research Comes of Age: Model Species for Studying Phytoplankton Biology and Diversity . The Plant Cell , 32 , 547 – 572 ( 2020 ).
- Show , P. L. , Tan , J. S. , Lee , S. Y. , Chew , K. W. , Lam , M. K. , Lim , J. W. , & Ho , S.-H. ). A Review on Microalgae Cultivation and Harvesting, and Their Biomass Extraction Processing Using Ionic Liquids . Bioengineered. 11 ( 1 ), 116 - 129 ( 2020 ) doi: 10.1080/21655979.2020.1711626
- Dineshkuma , R. , Narendran , R. & Sampathkumar , P. , Cultivation and harvesting of micro-algae for bio-fuel Production – A review , Indian Journal of Geo Marine Sciences 46 ( 09 ), 1731 - 1742 ( 2017 ).
- Noreña-Caro , D. , & Benton , M. G. , Cyanobacteria as photoautotrophic bio-factories of high-value chemicals . Journal of CO2 Utilization , 28 , 335 – 366 ( 2018 ).
- Sreekumar , N. , Giri Nandagopal , M. S. , Vasudevan , A. , Antony , R. , & Selvaraju , N. Marine microalgal culturing in open pond systems for biodiesel production—Critical parameters . Journal of Renewable and Sustainable Energy , 8 ( 2 ), 1 - 19 ( 2016 ). 023105. doi: 10.1063/1.4945574
- Kannan , D. C. , & Venkat , D. An open outdoor algal growth system of improved productivity for biofuel production . Journal of Chemical Technology & Biotechnology. 94 ( 1 ), 222 - 235 ( 2018 ). doi: 10.1002/jctb.5768
-
Sudhakar , K.
,
Premalatha , M.
, &
Rajesh , M.
,
Large-scale open pond algae biomass yield analysis in India: a case study
.
International Journal of Sustainable Energy
,
33
(
2
),
304
–
315
(
2014
). doi:
10.1080/14786451.2012.710617
10.1080/14786451.2012.710617 Google Scholar
- Rayen , F. , Behnam , T. , & Dominique , P. Optimization of a raceway pond system for wastewater treatment: a review . Critical Reviews in Biotechnology , 39 ( 3 ) 1 – 14 ( 2019 ). doi: 10.1080/07388551.2019.1571007
- Narala , R. R. , Garg , S. , Sharma , K. K. , Thomas-Hall , S. R. , Deme , M. , Li , Y. , & Schenk , P. M. ( 2016 ). Comparison of Microalgae Cultivation in Photobioreactor, Open Raceway Pond, and a Two-Stage Hybrid System . Frontiers in Energy Research , 4 , 29 - 40 . doi: 10.3389/fenrg.2016.00029
- Richardson , J. W. , Johnson , M. D. , & Outlaw , J. L. , Economic comparison of open pond raceways to photo bio-reactors for profitable production of algae for transportation fuels in the Southwest . Algal Research , 1 ( 1 ), 93 – 100 ( 2012 ). doi: 10.1016/j.algal.2012.04.001
- Zhou , X. , Yuan , S. , Chen , R. , & Ochieng , R. M. , Sustainable production of energy from microalgae: Review of culturing systems, economics, and modelling . Journal of Renewable and Sustainable Energy , 7 ( 1 ), 1 - 29 ( 2015 ).
- Singh , R. N. , & Sharma , S. , Development of suitable photobioreactor for algae production – A review . Renewable and Sustainable Energy Reviews , 16 ( 4 ), 2347 – 2353 ( 2012 ). doi: 10.1016/j.rser.2012.01.026
- Huang , Q. , Jiang , F. , Wang , L. , & Yang , C. ( 2017 ). Design of Photobioreactors for Mass Cultivation of Photosynthetic Organisms . Engineering , 3 ( 3 ), 318 – 329 . doi: 10.1016/j.eng.2017.03.020
- Mata , T. M. , Cameira , M. , Marques , F. , Santos , E. , Badenes , S. , Costa , L. , Martins , A. A. , Carbon footprint of microalgae production in photobioreactor . Energy Procedia , 153 , 432 – 437 ( 2018 ). doi: 10.1016/j.egypro.2018.10.039
- Sierra , E. , Acién , F. G. , Fernández , J. M. , García , J. L. , González , C. , & Molina , E. , Characterization of a flat plate photobioreactor for the production of microalgae . Chemical Engineering Journal , 138 ( 1-3 ), 136 – 147 ( 2008 ).
- Fernández , I. , Acién , F. G. , Berenguel , M. , & Guzmán , J. L. , First Principles Model of a Tubular Photobioreactor for Microalgal Production . Industrial & Engineering Chemistry Research , 53 ( 27 ), 11121 – 11136 ( 2014 ). doi: 10.1021/ie501438r
- Xu , L. , Weathers , P. J. , Xiong , X.-R. , & Liu , C.-Z. Microalgal bioreactors: Challenges and opportunities . Engineering in Life Sciences , 9 ( 3 ), 178 – 189 ( 2009 ).
- Deprá , M. C. , Mérida , L. G. R. , de Menezes , C. R. , Zepka , L. Q. , & Jacob-Lopes , E. , A new hybrid photobioreactor design for microalgae culture . Chemical Engineering Research and Design. 144 , 1 - 10 ( 2019 ). doi: 10.1016/j.cherd.2019.01.023
- Pal , P. , Chew , K. W. , Yen , H.-W. , Lim , J. W. , Lam , M. K. , & Show , P. L. , Cultivation of Oily Microalgae for the Production of Third-Generation Biofuels . Sustainability , 11 ( 19 ), 5424 - 5439 ( 2019 ). doi: 10.3390/su11195424
- Shamzi Mohamed , M. , Zee Wei , L. , & B. Ariff , A. Heterotrophic Cultivation of Microalgae for Production of Biodiesel . Recent Patents on Biotechnology , 5 ( 2 ), 95 – 107 ( 2011 ). doi: 10.2174/187220811796365699
- Morales-Sánchez , D. , Martinez-Rodriguez , O. A. , & Martinez , A. Heterotrophic cultivation of microalgae: production of metabolites of commercial interest . Journal of Chemical Technology & Biotechnology , 92 ( 5 ), 925 – 936 ( 2016 ).
- Ende , S.S.W. , Noke , A. Heterotrophic microalgae production on food waste and by-products . J Appl Phycol 31 , 1565 – 1571 ( 2019 ). https://doi.org/ 10.1007/s10811-018-1697-6
- Lowrey , J. , Brooks , M.S. & McGinn , P.J. Heterotrophic and mixotrophic cultivation of microalgae for biodiesel production in agricultural wastewaters and associated challenges—a critical review . J Appl Phycol 27 , 1485 – 1498 ( 2015 ).
- Zhan , J. , Rong , J. , & Wang , Q. Mixotrophic cultivation, a preferable microalgae cultivation mode for biomass/bioenergy production, and bioreme-diation, advances and prospect . International Journal of Hydrogen Energy , 42 ( 12 ), 8505 – 8517 ( 2017 ). doi: 10.1016/j.ijhydene.2016.12.021
- Li , Y.-R. , Tsai , W.-T. , Hsu , Y.-C. , Xie , M.-Z. , & Chen , J.-J. , Comparison of Autotrophic and Mixotrophic Cultivation of Green Microalgal for Biodiesel Production . Energy Procedia , 52 , 371 – 376 ( 2014 ). doi: 10.1016/j.egypro.2014.07.088
- Wang , J. , Yang , H. , & Wang , F. ( 2014 ). Mixotrophic Cultivation of Microalgae for Biodiesel Production: Status and Prospects . Applied Biochemistry and Biotechnology , 172 ( 7 ), 3307 – 3329 . doi: 10.1007/s12010-014-0729-1
- Pereira , M. I. B. , Chagas , B. M. E. , Sassi , R. , Medeiros , G. F. , Aguiar , E. M. , Borba , L. H. F. , Rangel , A. H. N. , Mixotrophic cultivation of Spirulina platensis in dairy wastewater: Effects on the production of biomass, biochemical composition and antioxidant capacity . PLOS ONE , 14 ( 10 ), 1 - 17 ( 2019 ). e0224294.
- Chen , C.-Y. , Yeh , K.-L. , Aisyah , R. , Lee , D.-J. , & Chang , J.-S. , Cultivation, photobioreactor design and harvesting of microalgae for biodiesel production: A critical review . Bioresource Technology , 102 ( 1 ), 71 – 81 ( 2011 ).
- Liu , C.-H. , Chang , C.-Y. , Liao , Q. , Zhu , X. , & Chang , J.-S , Photoheterotrophic growth of Chlorella vulgaris ESP6 on organic acids from dark hydrogen fermentation effluents . Bioresource Technology , 145 , 331 – 336 ( 2013 ).
- Nur , M.M.A. , Buma , A.G.J. Opportunities and Challenges of Microalgal Cultivation on Wastewater, with Special Focus on Palm Oil Mill Effluent and the Production of High Value Compounds . Waste Biomass Valor 10 , 2079 – 2097 ( 2019 ). https://doi.org/ 10.1007/s12649-018-0256-3
- Patel , A. , Matsakas , L. , Rova , U. et al . Heterotrophic cultivation of Auxenochlorella protothecoides using forest biomass as a feedstock for sustainable biodiesel production . Biotechnol Biofuels 11 , 169 - 184 ( 2018 ). https://doi.org/ 10.1186/s13068-018-1173-1
- Benavente-Valdés , J. R. , Aguilar , C. , Contreras-Esquivel , J. C. , Méndez-Zavala , A. , & Montañez , J. , Strategies to enhance the production of photosynthetic pigments and lipids in chlorophycae species . Biotechnology Reports , 10 , 117 – 125 ( 2016 ). doi: 10.1016/j.btre.2016.04.001
- Usher , P. K. , Ross , A. B. , Camargo-Valero , M. A. , Tomlin , A. S. , & Gale , W. F. , An overview of the potential environmental impacts of large-scale microalgae cultivation . Biofuels , 5 ( 3 ), 331 – 349 ( 2014 ). doi: 10.1080/17597269.2014.913925
- Han , P. , Lu , Q. , Fan , L. , & Zhou , W. A Review on the Use of Microalgae for Sustainable Aquaculture . Applied Sciences , 9 ( 11 ), 2377 - 2396 ( 2019 ).
- Bhola , V. , Swalaha , F. , Ranjith Kumar , R. et al . Overview of the potential of microalgae for CO2 sequestration . Int. J. Environ. Sci. Technol. 11 , 2103 – 2118 ( 2014 ). https://doi.org/ 10.1007/s13762-013-0487-6
- Show , P. , Tang , M. , Nagarajan , D. , Ling , T. , Ooi , C.-W. , & Chang , J.-S. A Holistic Approach to Managing Microalgae for Biofuel Applications . International Journal of Molecular Sciences , 18 ( 1 ), 215 - 249 ( 2017 ). doi: 10.3390/ijms18010215
- Sharma PK , Saharia M , Srivastava R , Kumar S and Sahoo L ., Tailoring microalgae for efficient biofuel production , Front. Mar. Sci. 5 : 382 - 437 ( 2018 ).
- Han , S.-F. , Jin , W.-B. , Tu , R.-J. , & Wu , W.-M. , Biofuel production from microalgae as feedstock: current status and potential . Critical Reviews in Biotechnology , 35 ( 2 ), 255 – 268 ( 2014 ). doi: 10.3109/07388551.2013.835301
- Simas-Rodrigues , C. , Villela , H. D. M. , Martins , A. P. , Marques , L. G. , Colepicolo , P. , & Tonon , A. P. , Microalgae for economic applications: advantages and perspectives for bioethanol . Journal of Experimental Botany , 66 ( 14 ), 4097 – 4108 ( 2015 ). doi: 10.1093/jxb/erv130
-
Kröger , M.
, &
Müller-Langer , F.
,
Review on possible algal-biofuel production processes
.
Biofuels
,
3
(
3
),
333
–
349
(
2012
). doi:
10.4155/bfs.12.14
10.4155/bfs.12.14 Google Scholar
- Koyande , A. K. , Show , P.-L. , Guo , R. , Tang , B. , Ogino , C. , & Chang , J.-S. , Bio-processing of algal bio-refinery: review on current advances and future perspectives . Bioengineered , 10 ( 1 ), 574 – 592 ( 2019 ). doi: 10.1080/21655979.2019.1679697