The spleen
Catherine Hildyard
Department of Haematology, Buckinghamshire Healthcare NHS Trust, UK
Search for more papers by this authorDaniel Royston
Department of Haematopathology, Oxford University Hospitals NHS Foundation Trust, UK
Search for more papers by this authorCatherine Hildyard
Department of Haematology, Buckinghamshire Healthcare NHS Trust, UK
Search for more papers by this authorDaniel Royston
Department of Haematopathology, Oxford University Hospitals NHS Foundation Trust, UK
Search for more papers by this authorAdam J Mead PhD, FRCP, FRCPath, FMedSci
Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorMichael A Laffan DM, MRCP, FRCPath
Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK
Search for more papers by this authorGraham P Collins DPhil, FRCP, FRCPath
Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK
Search for more papers by this authorDeborah Hay DPhil, MRCP, FRCPath
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorA Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci
Emeritus Professor of Haematology Honorary Consultant Haematologist
University College London, London, UK
Royal Free Hospital, London, UK
Search for more papers by this authorSummary
The spleen performs diverse immunological, haemodynamic and blood filtering functions that are variously perturbed in primary splenic disorders and various systemic diseases. Splenic form and function are closely related, with an understanding of key pathological processes lending insight to the clinical manifestations of splenic disease. The appropriate investigation, diagnosis and management of patients with splenic disorders can be challenging and requires an integrated multidisciplinary approach.
Selected bibliography
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