Laboratory diagnosis of haematological neoplasms
Barbara J Bain
Centre for Haematology, Department of Immunology and Inflammation, St Mary's Hospital, London, UK
Search for more papers by this authorTorsten Haferlach
MLL Munich Leukemia Laboratory, Munich, Germany
Search for more papers by this authorBarbara J Bain
Centre for Haematology, Department of Immunology and Inflammation, St Mary's Hospital, London, UK
Search for more papers by this authorTorsten Haferlach
MLL Munich Leukemia Laboratory, Munich, Germany
Search for more papers by this authorAdam J Mead PhD, FRCP, FRCPath, FMedSci
Haematopoietic Stem Cell Biology Laboratory, Medical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorMichael A Laffan DM, MRCP, FRCPath
Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK
Search for more papers by this authorGraham P Collins DPhil, FRCP, FRCPath
Department of Haematology, Oxford Cancer and Haematology Centre, Oxford, UK
Search for more papers by this authorDeborah Hay DPhil, MRCP, FRCPath
Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK
Search for more papers by this authorA Victor Hoffbrand MA, DM, FRCP, FRCPath, FRCP (Edin), DSc, FMedSci
Emeritus Professor of Haematology Honorary Consultant Haematologist
University College London, London, UK
Royal Free Hospital, London, UK
Search for more papers by this authorSummary
This chapter deals with the laboratory diagnosis of haematological neoplasms, specifically leukaemias and lymphomas, myelodysplastic syndromes, myeloproliferative and myelodysplastic/myeloproliferative neoplasms and multiple myeloma. It includes consideration of the blood count, blood film and bone marrow aspirate assessment, cytochemistry, trephine biopsy histology, immunophenotyping (both flow cytometry and immunohistochemistry) and cytogenetic and molecular analysis including fluorescence in situ hybridization.
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