Chapter 86

Antithrombotic Strategies in Endovascular Interventions

Current Status and Future Directions

First published: 06 May 2022

Summary

  • PAD is highly prevalent disease with an estimated 200 million globally affected by it and carries a high risk for CAD, MACE and adverse events affecting the limbs, including acute limb ischemia and major amputation.
  • Understanding the disease process and management is an ever evolving process.
  • Multiple effective treatment modalities including medical management are available in the prevention and treatment of PAD.

Peripheral artery disease (PAD) affects the cerebral circulation and extracranial vessels, the aorta, great vessels, mesenteric and renal arteries, and the lower extremities. In recent years the number of endovascular procedures to treat this condition have significantly increased; however, despite this, little level 1 evidence is available regarding the role of antithrombotic therapy in patients undergoing these endovascular procedures. The current practice in this regard is heterogeneous and has been mainly driven by data from coronary artery disease and percutaneous coronary intervention (PCI). This chapter discusses the role of antithrombotic agents for endovascular intervention.

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