This chapter first discusses the capabilities of 5G as defined in Release 15 that can be used for the manufacturing industry and describes the use cases needed for the manufacturing industry. The illustrated use cases can be roughly classified into five major characteristics: factory automation, processes automation, human–machine interfaces and production IT, logistics and warehousing, as well as monitoring and maintenance. It should be clear that a particular use case may have one or more of the characteristics. The chapter discusses each in order. In Release 16, 3GPP will start to close the gaps from the information and communication technology 5G to that needed by the smart factory. As 3GPP completes its work, it can be readily seen that all aspects of the untethered communication can be met by new 3GPP releases and will make 5G a key enabler for redefining the manufacturing process.