Chapter 66
Myeloproliferative Neoplasms
Eric J. Fish,
Eric J. Fish
Search for more papers by this authorEric J. Fish,
Eric J. Fish
Search for more papers by this authorBook Editor(s):Marjory B. Brooks DVM, DACVIM,
Kendal E. Harr DVM, MS, DACVP,
Davis M. Seelig DVM, PhD, DACVP,
K. Jane Wardrop DVM, MS, DACVP,
Douglas J. Weiss DVM, PhD, DACVP,
Marjory B. Brooks DVM, DACVIM
Director, Comparative Coagulation Section
Animal Health Diagnostic Center, Cornell University, Ithaca, New York, USA
Search for more papers by this authorKendal E. Harr DVM, MS, DACVP
URIKA, LLC, Mukilteo, Washington, USA
Search for more papers by this authorDavis M. Seelig DVM, PhD, DACVP
Associate Professor, Clinical Pathology
Department of Veterinary Clinical Sciences, University of Minnesota, College of Veterinary Medicine, St. Paul, Minnesota, USA
Search for more papers by this authorK. Jane Wardrop DVM, MS, DACVP
Professor and Director, Clinical Pathology Laboratory
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA
Search for more papers by this authorDouglas J. Weiss DVM, PhD, DACVP
Emeritus Professor
College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA
Search for more papers by this authorSummary
Myeloproliferative neoplasm (MPN) in humans and domestic animals can usually be diagnosed with reasonable certainty based on history, clinical signs, and serial CBCs. Diagnosis of MPN in human patients and experimental settings are aided by a wider array of tools to prove a clonal etiology, including fluorescence in situ hybridization cytogenetics, X-linked clonality assay, and specific genetic assays for driver mutations. The veterinary classification of MPN has not been independently updated since adoption of the 2016 WHO criteria and remains rudimentary and based on sporadic case reports rather than large studies. MPNs include several variants that overproduce leukocytes, including chronic neutrophilic leukemia, chronic myeloid leukemia, and chronic eosinophilic leukemia. Polycythemia vera is an uncommon MPN in dogs, cats, and calves characterized by overproduction of mature erythrocytes. Myelofibrosis is the proliferation of stromal fibroblasts that produce reticulin and collagen fibrils.
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