Chapter 2
Using Polymers to Enhance the Carbon Nanomaterial Biointerface
Goutam Pramanik,
Jitka Neburkova,
Vaclav Vanek,
Mona Jani,
Marek Kindermann,
Petr Cigler,
Goutam Pramanik
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorJitka Neburkova
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Charles University, First Faculty of Medicine, Prague, Czech Republic
Search for more papers by this authorVaclav Vanek
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorMona Jani
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorMarek Kindermann
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Institute of Microbiology of the CAS, Czech Republic
University of Chemistry and Technology, Czech Republic
Search for more papers by this authorPetr Cigler
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorGoutam Pramanik,
Jitka Neburkova,
Vaclav Vanek,
Mona Jani,
Marek Kindermann,
Petr Cigler,
Goutam Pramanik
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorJitka Neburkova
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Charles University, First Faculty of Medicine, Prague, Czech Republic
Search for more papers by this authorVaclav Vanek
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorMona Jani
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorMarek Kindermann
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Institute of Microbiology of the CAS, Czech Republic
University of Chemistry and Technology, Czech Republic
Search for more papers by this authorPetr Cigler
Institute of Organic Chemistry and Biochemistry of the CAS, Czech Republic
Search for more papers by this authorBook Editor(s):Yuen Yung Hui,
Huan-Cheng Chang,
Haifeng Dong,
Xueji Zhang,
Yuen Yung Hui
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Republic of China
Search for more papers by this authorHuan-Cheng Chang
Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Republic of China
Search for more papers by this authorHaifeng Dong
University of Science and Technology Beijing, P.R. China
Search for more papers by this authorXueji Zhang
University of Science and Technology Beijing, P.R. China
Search for more papers by this authorSummary
This chapter focuses on functionalization of carbon nanomaterials (CNMs) with polymers for biomedical applications. A classical theoretical approach based on Derjaguin-Landau-Verwey-Overbeek (DLVO) theory is commonly used to predict the stability of a colloidal system. CNMs can be functionalized with polymers via two types of approaches: noncovalent coating and covalent modification. The physicochemical properties of CNMs are determined by their intrinsic nanostructure. The chapter discusses the effect of polymer functionalization on the spectral properties of various CNMs. Stimuli-responsive polymers respond to their environment by changing their physical and/or chemical properties. Among stimuli-responsive polymers, thermoresponsive polymers have been exploited most abundantly to modify carbon nanoparticles. The development of nonviral, nonimmunogenic, and biocompatible vectors for efficient intracellular transfection of nucleic acids (NAs) is one of the challenges facing future gene therapy approaches. The surface of the CNMs can be functionalized by covalent or noncovalent attachment of macromolecular layers to create reliable nonviral gene delivery vectors.
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