Pityriasis rosea is a self-limited exanthem likely to be related to viral infections, particularly endogenous reactivation or primary infection of human herpesviruses 7 and 6.

A prodrome of coryzal symptoms is common. In around 20–30% of childhood cases, a herald patch is seen. The secondary generalized eruption then occurs 2–3 weeks later, with usually smaller macules with peripheral collarette scaling on the trunk and proximal aspects of the extremities. The orientation of most lesions follows lines of skin creases. Spontaneous remission then occurs 2–12 weeks after the eruption of the herald patch or the generalized eruption.

Many children exhibit atypical variants of this exanthem. Validated diagnostic criteria are available and are particularly applicable for children with marginal symptoms. Classification systems are available for delineating subclasses, and allow for choice of treatment modalities as well as subgroup analyses in laboratory-based and clinical investigations.

Pityriasis rosea usually does not have significant impacts on children and adolescents. Symptomatic treatments usually suffice. The benefits of active interventions with antiviral agents are being actively investigated.