Psoriasis
Epidemiology
Matthias Augustin
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Search for more papers by this authorMarc Alexander Radtke
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Search for more papers by this authorMatthias Augustin
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Search for more papers by this authorMarc Alexander Radtke
Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany
Search for more papers by this authorPeter Hoeger
Search for more papers by this authorVeronica Kinsler
Search for more papers by this authorAlbert Yan
Search for more papers by this authorJohn Harper
Search for more papers by this authorArnold Oranje
Search for more papers by this authorChristine Bodemer
Search for more papers by this authorMargarita Larralde
Search for more papers by this authorVibhu Mendiratta
Search for more papers by this authorDiana Purvis
Search for more papers by this authorSummary
Psoriasis vulgaris can occur at any age, and prevalence in childhood ranges between 0.1% and 1.5%, showing a nearly linear increase from birth to the age of 18 years. Early onset is more frequently associated with a positive family history and heralds a graver prognosis. The median age at onset of psoriasis was found to be between 7 and 10 years. Data from the UK suggest a prevalence of 0.55% in the age group 0–9 years and 1.37% in the age group 10–19 years, which is consistent with data from the Netherlands, Germany and the USA. Estimates of the proportion of psoriatic children with a positive family history in any family member range between 4.5% and 88%. Psoriasis may represent 4.1% of all dermatological diseases under the age of 16 in Europe and North America. The reported percentage of children developing guttate psoriasis ranges from 6.4% to 44%. Although guttate psoriasis is mostly self-limiting, resolving within 3–4 months of onset, the long-term prognosis is unknown. About one third of children with guttate psoriasis develop classical plaque-type disease. Nail involvement is reported in between 2% and 39.3% of children. Increasing evidence suggests an association between juvenile psoriasis and other morbidities including hyperlipidaemia, obesity, hypertension, diabetes mellitus and rheumatoid arthritis. Disease patterns of the metabolic syndrome may occur independently of patient age and disease duration. A high proportion of children and adolescents will continue to have psoriatic disease and comorbidity throughout their lives, suggesting the need for careful work-up and specialized care and information.
References
- Raychaudhuri SP, Gross J. A comparative study of pediatric onset psoriasis with adult onset psoriasis. Pediatr Dermatol 2000; 17: 174–8.
- De Jager MEA, van de Kerkhof PCM, De Jong EM, Seyger MM. Epidemiology and prescribed treatments in childhood psoriasis: A survey among medical professionals. J Dermatolog Treat 2009; 20: 254–8.
- Yang YC, Cheng YW, Lai CS, Chen W. Prevalence of childhood acne, ephelides, warts, atopic dermatitis, psoriasis, alopecia areata and keloid in Kaohsiung County, Taiwan: a community-based clinical survey. J Eur Acad Dermatol Venereol 2007; 21: 643–9.
- Rogers M. Childhood psoriasis. Curr Opin Pediatr 2002; 14: 404–9.
- Fond L, Michel JL, Gentil-Perret A et al. Psoriasis in childhood. Arch Pediatr 1999; 6: 669–74.
- Morris A, Rogers M, Fischer G, Williams K. Childhood psoriasis: a clinical review of 1262 cases. Pediatr Dermatol 2001; 18: 188–98.
- Stefanaki C, Lagogianni E, Kontochristopoulos G et al. Psoriasis in children: a retrospective analysis. J Eur Acad Dermatol Venereol 2011; 25: 417–21.
- Bronckers IMGJ, Paller AS, van Geel MJ. Psoriasis in children and adolescents: diagnosis, management and comorbidities. Paediatr Drugs 2015; 17: 373–84.
- Parisi R, Symmons DP, Griffiths CE, Ashcroft DM. Identification, management of psoriasis and associated comorbidity project. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 2013; 133: 377–85.
- Marcoux D, de Prost Y. Pediatric psoriasis revisited. J Cutan Med Surg 2002; 6(3 suppl): 22–8.
- Farber EM, Carlsen RA. Psoriasis in childhood. Calif Med 1966; 105: 415–20.
- Kaur I, Handa S, Kumar B. Natural history of psoriasis: a study from the Indian subcontinent. J Dermatol 1997; 24: 230–4.
- Burden-Teh E, Thomas KS, Ratib S et al. The epidemiology of childhood psoriasis: a scoping review. Br J Dermatol 2016; 174: 1242–57.
- Farber EM, Mullen RH, Jakobs AH, Nall L. Infantile psoriasis: a follow-up study. Pediatr Dermatol 1986; 3: 237–43.
- Augustin M, Glaeske G, Radtke MA et al. Epidemiology and comorbidity of psoriasis in children. Br J Dermatol 2010; 162: 633–6.
- Radtke MA, Fölster-Holst R, Beikert F et al. Juvenile psoriasis: rewarding endeavours in contemporary dermatology and pediatrics. G Ital Dermatol Venereol 2011; 146: 31–45.
- Augustin M, Radtke MA, Glaeske G et al. Epidemiology and comorbidity in children with psoriasis and atopic eczema. Dermatology 2015; 231: 35–40.
- Gelfand JM, Weinstein R, Porter SB et al. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol 2005; 141: 1537–41.
- Yamamah GA, Emam HM, Abdelhamid MF et al. Epidemiologic study of dermatologic disorders among children in South Sinai, Egypt. Int J Dermatol 2012; 51: 1180–5.
- Chen GY, Cheng YW, Wang CY et al. Prevalence of skin diseases among schoolchildren in Magong, Penghu, Taiwan: a community-based clinical survey. J Formos Med Assoc 2008; 107: 21–9.
- Matusiewicz D, Koerber A, Schadendorf D et al. Childhood psoriasis: an analysis of German health insurance data. Pediatr Dermatol 2014; 31: 8–13.
- Kämpfe S, Augustin M, Schäfer I et al. Prevalence and health care situation of juvenile psoriasis in Germany. Exp Dermatol 2012; 21(3): e21.
- Cantarutti A, Donà D, Visentin F et al. Epidemiology of frequently occurring skin diseases in Italian children from 2006 to 2012: a retrospective population-based study. Pediatr Dermatol 2015; 32: 668–78.
- Larsson PA, Lidén S. Prevalence of skin diseases among adolescents 12–16 years of age. Acta Derm Venereol 1980; 60: 415–23.
- World Health Organization (WHO). Global report on psoriasis. 2016. http://apps.who.int/iris/bitstream/10665/204417/1/9789241565189_eng.pdf (accessed 19 November 2018).
- Naldi L, Parazzini F, Gallus S; GISED Study Centres. Prevalence of atopic dermatitis in Italian schoolchildren: factors affecting its variation. Acta Derm Venereol 2009; 89: 122–5.
- Schmitt J, Apfelbacher C. Epidemiology of pediatric psoriasis: a representative German cross-sectional study. Exp Dermatol 2010; 19: 219.
- Fan X, Xiao FL, Yang S et al. Childhood psoriasis: a study of 277 patients from China. J Eur Acad Dermatol Venereol 2007; 21: 762–5.
- Seyhan M, Coskun BK, Saglam H et al. Psoriasis in childhood and adolescence: evaluation of demographic and clinical features. Pediatr Int 2006; 48: 525–30.
- Kumar B, Jain R, Sandhu K et al. Epidemiology of childhood psoriasis: a study of 419 patients from northern India. Int J Dermatol 2004; 43: 654–8.
- Nanda A, Kaur S, Kaur I, Kumar B. Childhood psoriasis: an epidemiologic survey of 112 patients. Pediatr Dermatol 1990; 7: 19–21.
- Farber EM, Jacobs AH. Infantile psoriasis. Am J Clin Dis Child 1977; 131: 1266–9.
- Henseler T, Christophers E. Psoriasis of early and late onset: characterization of two types of psoriasis vulgaris. J Am Acad Dermatol 1985; 13: 450–6.
- Tollefson MM, Crowson CS, McEvoy MT, Kremers HM. Incidence of psoriasis in children: A population-based study. J Am Acad Dermatol 2010; 62: 979–87.
- Rachakonda TD, Schupp CW, Armstrong AW. Psoriasis prevalence among adults in the United States. J Am Acad Dermatol 2014; 70: 512–6.
- Kurd SK, Gelfand JM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003–2004. J Am Acad Dermatol 2009; 60: 218–24.
- Shao CG, Zhang GW, Wang GC. Distribution of psoriasis in China: a nationwide screening. Proc Chin Acad Med Sci Peking Union Med Coll 1987; 2: 59–65.
- Ding X, Wang T, Shen Y et al. Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol 2012; 22: 663–7.
- Ferrándiz C, Bordas X, García-Patos V et al. Prevalence of psoriasis in Spain (Epiderma Project: phase I). J Eur Acad Dermatol Venereol 2001; 15: 20–3.
- Ferrándiz C, Carrascosa JM, Toro M. Prevalence of psoriasis in Spain in the age of biologics. Actas Dermo-Sifiliográficas 2014; 105: 504–9.
- Danielsen K, Olsen AO, Wilsgaard T, Furberg AS. Is the prevalence of psoriasis increasing? A 30–year follow-up of a population–based cohort. Br J Dermatol 2013; 168: 1303–10.
- Hägg D, Eriksson M, Sundström A, Schmitt-Egenolf M. The higher proportion of men with psoriasis treated with biologics may be explained by more severe disease in men. PLoS ONE 2013; 8: e63619.
- Boehncke W-H, Schön MP. Psoriasis. Lancet 2015; 386: 983–94.
- Martin BA, Chalmers RJ, Telfer NR. How great is the risk of further psoriasis following a single episode of acute guttate psoriasis? Arch Dermatol 1996; 132: 717–8.
- Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet 2007; 370: 263–71.
- Nyfors A, Lemholt K. Psoriasis in children. A short review and a survey of 245 cases. Br J Dermatol 1975; 92: 437–42.
- Horton DB, Scott FI, Haynes K et al. Antibiotic exposure, infection, and the development of pediatric psoriasis: a nested case-control study. JAMA Dermatol 2016; 152: 191–9.
- Kwon HH, Na SJ, Jo SJ, Youn JI. Epidemiology and clinical features of pediatric psoriasis in tertiary referral psoriasis clinic. J Dermatol 2012; 39: 260–4.
- Kim SK, Kang HY, Kim YC, Lee ES. Clinical comparison of psoriasis in Korean adults and children: correlation with serum anti-streptolysin O titers. Arch Dermatol Res 2010; 302: 295–9.
- Chandran NS, Gao F, Goon AT et al. Clinical characteristics of childhood psoriasis in a multi-ethnic Asian population. J Dermatol 2012; 39: 278–9.
- Al-Fouzan AS, Nanda A. A survey of childhood psoriasis in Kuwait. Pediatr Dermatol 1994; 11: 116–9.
- Mercy K, Kwasny M, Cordoro KM et al. Clinical manifestations of pediatric psoriasis: results of a multicenter study in the United States. Pediatr Dermatol 2013; 30: 424–8.
- Cohen R, Robinson D Jr, Paramore C et al. Autoimmune disease concomitance among inflammatory bowel disease patients in the United States, 2001–2002. Inflamm Bowel Dis 2008; 14: 738–43.
- Wolf N, Quaranta M, Prescott NJ et al. Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. J Med Genet 2008; 45: 114–6.
- Piruzian ES, Ishkin AA, Nikolskaia TA et al. The comparative analysis of psoriasis and Crohn disease molecular-genetical processes under pathological conditions. Mol Biol (Mosk) 2009; 43: 175–9.
- Li Y, Begovich AB. Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis. Semin Immunol 2009; 21: 318–27.
- Annunziato F, Cosmi L, Liotta F et al. Type 17 T helper cells-origins, features and possible roles in rheumatic disease. Nat Rev Rheumatol 2009; 5: 325–31.
- Silverberg JI, Simpson EL. Association between severe eczema in children and multiple comorbid conditions and increased health care utilization. Pediatr Allergy Immunol 2013; 24: 476–86.
- Kimball AB, Wu EQ, Guerin A et al. Risks of developing psychiatric disorders in pediatric patients with psoriasis. J Am Acad Dermatol 2012; 67: 651–7.e1–2.
- Ferreira BI, Abreu JL, Reis JP, Figueiredo AM. Psoriasis and associated psychiatric disorders: a systematic review on etiopathogenesis and clinical correlation. J Clin Aesthet Dermatol 2016; 9: 36–43.