Point-of-care ultrasound (PoCUS) has a number of indications in paediatric musculoskeletal (MSK) conditions, and provides many advantages over traditional imaging and diagnostic techniques. This chapter attention focusses on PoCUS and its application to more acute presentations, including infectious, inflammatory and traumatic conditions. In terms of examiner technique, adequate ultrasound gel, appropriate probe manipulation, probe stabilisation using the hypothenar eminence and little finger of the examiner's hand, as well as multi-angle views to evaluate for anisotropy, are all important to obtaining high-quality clinically useful ultrasound images. PoCUS can be useful in the diagnosis, evaluation and also often the treatment of paediatric skin and soft-tissue infections. Common entities evaluated are cellulitis, abscess and acute haematogenous osteomyelitis. Retained foreign bodies (FBs), dislocation/subluxation in children, ligament, tendon injuries, and joint effusions are also discussed. A high-frequency (7-12 MHz) probe with paediatric hip/MSK preset should be used if available.