The Pragmatic Randomized Controlled Trials in Health Care (Practihc) extension to the Consolidated Standards of Reporting Trials (CONSORT) Statement is a guidance document for authors reporting randomized trials of interventions directly aimed at improving health status, or healthcare processes or outcomes, under real-world conditions, that is, under the conditions of healthcare settings as usually organized, resourced, and run. Practihc may be useful for peer reviewers and editors reviewing reports of randomized trials, for authors wishing to provide a full report oriented toward decision makers, and for readers wanting to gauge the relevance of a randomized trial conducted elsewhere, to the care setting in which they might wish to use the evaluated intervention. The Practihc extension has been developed to help authors who evaluate interventions with the goal of using their published results to influence decisions on “real-world” use of the intervention that they have evaluated.