Chapter 4

Specialized Pro-Resolving Lipid Derived Fatty Acid Mediators: Wiring the Circuitry of Effector Immune Homeostasis

Gabrielle Fredman

Gabrielle Fredman

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

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Charles N. Serhan
First published: 13 April 2012

Summary

This chapter contains sections titled:

  • Inflammation: The Cardinal Signs

  • Complete Resolution and Tissue Homeostasis is the Ideal Outcome of Acute Inflammation

  • Lipoxins, Resolvins, Protectins and Maresins: Semper Vigilantes of Anti-Inflammation and Pro-Resolution

  • Resolution of Inflammation is an Actively Regulated Process in Vivo

  • Resolvins and Protectins are Protective in Experimental Models of Inflammatory Diseases

  • Specialized Pro-Resolving Lipid Mediators in Oral Medicine: Restoration of Tissue Homeostasis in Experimental Periodontitis

  • Resolution and Wound Healing

  • Anti-Inflammation vs. Pro-Resolution

  • Clinical Implications and the Development of Stable Analogs

  • Conclusions

  • Acknowledgments

  • References

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