Chapter 12
Wound Healing Around Dental Implants
Cristina Cunha Villar,
Guy Huynh-Ba,
Michael P. Mills,
David L. Cochran,
Cristina Cunha Villar
Search for more papers by this authorGuy Huynh-Ba
Search for more papers by this authorMichael P. Mills
Search for more papers by this authorDavid L. Cochran
Search for more papers by this authorCristina Cunha Villar,
Guy Huynh-Ba,
Michael P. Mills,
David L. Cochran,
Cristina Cunha Villar
Search for more papers by this authorGuy Huynh-Ba
Search for more papers by this authorMichael P. Mills
Search for more papers by this authorDavid L. Cochran
Search for more papers by this authorBook Editor(s):Hannu Larjava,
Hannu Larjava
Search for more papers by this authorSummary
This chapter contains sections titled:
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Introduction
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Historical Development
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Titanium – The Metal of Choice
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Healing Following Implant Placement
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Peri-Implant Soft Tissue Healing
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Implant/Peri-Implant Mucosa Interface
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Peri-Implant Hard Tissue Healing
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FROM Healing to Clinical Application
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Implant Stability Testing
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Wound Healing and Loading Protocols
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Conclusions
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References
References
- Abrahamsson, I., Berglundh, T. and Lindhe, J. (1997) The mucosal barrier following abutment dis/reconnection. An experimental study in dogs. J Clin Periodontol 24: 568–572.
- Abrahamsson, I., Berglundh, T., Glantz, P.O. and Lindhe, J. (1998) The mucosal attachment at different abutments. An experimental study in dogs. J Clin Periodontol 25: 721–727.
- Abrahamsson, I., Berglundh, T., Linder, E., Lang, N.P. and Lindhe, J. (2004) Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog. Clin Oral Implants Res 15: 381–392.
- Abrahamsson, I., Berglundh, T., Moon, I.S. and Lindhe, J. (1999) Peri-implant tissues at submerged and non-submerged titanium implants. J Clin Periodontol 26: 600–607.
- Abrahamsson, I., Berglundh, T., Wennstrom, J. and Lindhe, J. (1996) The peri-implant hard and soft tissues at different implant systems. A comparative study in the dog. Clin Oral Implants Res 7: 212–219.
- Abrahamsson, I., Zitzmann, N.U., Berglundh, T., Linder, E., Wennerberg, A. and Lindhe, J. (2002) The mucosal attachment to titanium implants with different surface characteristics: an experimental study in dogs. J Clin Periodontol 29: 448–455.
- Abrahamsson, I., Zitzmann, N.U., Berglundh, T., Wennerberg, A. and Lindhe, J. (2001) Bone and soft tissue integration to titanium implants with different surface topography: an experimental study in the dog. Int J Oral Maxillofac Implants 16: 323–332.
- Achilli, A., Tura, F. and Euwe, E. (2007) Immediate/early function with tapered implants supporting maxillary and mandibular posterior fixed partial dentures: preliminary results of a prospective multicenter study. J Prosthet Dent 97: S52–58.
- Adell, R., Lekholm, U., Rockler, B. and Branemark, P.I. (1981) A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg 10: 387–416.
- Akagawa, Y., Hashimoto, M., Kondo, N., Satomi, K., Takata, T. and Tsuru, H. (1986) Initial bone-implant interfaces of submergible and supramergible endosseous single-crystal sapphire implants. J Prosthet Dent 55: 96–100.
- Albrektsson, T., Zarb, G., Worthington, P. and Eriksson, A.R. (1986) The long-term efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1: 11–25.
- Albrektsson, T. and Zarb, G.A. (1989) The Branemark Osseointegrated Implant, pp. 21–23. Quintessence Publishing, Chicago.
- Albrektsson, T., Branemark, P.I., Hansson, H.A. and Lindstrom, J. (1981) Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand 52: 155–170.
- Albrektsson, T., Sennerby, L. and Wennerberg, A. (2008) State of the art of oral implants. Periodontol 47: 15–26.
- Aparicio, C., Lang, N.P. and Rangert, B. (2006) Validity and clinical significance of biomechanical testing of implant/bone interface. Clin Oral Implants Res 17 Suppl 2: 2–7.
- Atsumi, M., Park, S.H. and Wang, H.L. (2007) Methods used to assess implant stability: current status. Int J Oral Maxillofac Implants 22: 743–754.
- Babbush, C.A., Kent, J.N. and Misiek, D.J. (1986) Titanium plasma-sprayed (tps) screw implants for the reconstruction of the edentulous mandible. J Oral Maxillofac Surg 44: 274–282.
- Balleri, P., Cozzolino, A., Ghelli, L., Momicchioli, G. and Varriale, A. (2002) Stability measurements of osseointegrated implants using osstell in partially edentulous jaws after 1 year of loading: a pilot study. Clin Implant Dent Relat Res 4: 128–132.
- Barewal, R.M., Oates, T.W., Meredith, N. and Cochran, D.L. (2003) Resonance frequency measurement of implant stability in vivo on implants with a sandblasted and acid-etched surface. Int J Oral Maxillofac Implants 18: 641–651.
- Bashutski, J.D., D'Silva, N.J. and Wang, H.L. (2009) Implant compression necrosis: current understanding and case report. J Periodontol 80: 700–704.
- Becker, W. and Gansky, S.A. (2007) Periotest comes with many false alarms for predicting early implant loss. J Evid Based Dent Pract 7: 125–126.
- Berglundh, T. and Lindhe, J. (1996) Dimension of the periimplant mucosa. Biological width revisited. J Clin Periodontol 23: 971–973.
- Berglundh, T., Abrahamsson, I., Albouy, J.P. and Lindhe, J. (2007) Bone healing at implants with a fluoridemodified surface: an experimental study in dogs. Clin Oral Implants Res 18: 147–152.
- Berglundh, T., Abrahamsson, I., Lang, N.P. and Lindhe, J. (2003) De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res 14: 251–262.
- Berglundh, T., Abrahamsson, I., Welander, M., Lang, N.P. and Lindhe, J. (2007) Morphogenesis of the peri-implant mucosa: an experimental study in dogs. Clin Oral Implants Res 18: 1–8.
- Berglundh, T., Lindhe, J., Ericsson, I., Marinello, C.P., Liljenberg, B. and Thomsen, P. (1991) The soft tissue barrier at implants and teeth. Clin Oral Implants Res 2: 81–90.
-
Berzins, A., Shah, B., Weinans, H. and Sumner, D.R. (1997) Nondestructive measurements of implant-bone interface shear modulus and effects of implant geometry in pull-out tests. J Biomed Mater Res 34: 337–340.
10.1002/(SICI)1097-4636(19970305)34:3<337::AID-JBM8>3.0.CO;2-L CAS PubMed Web of Science® Google Scholar
- Binon, P.P. (2000) Implants and components: entering the new millennium. Int J Oral Maxillofac Implants 15: 76–94.
- Bischof, M., Nedir, R., Szmukler-Moncler, S., Bernard, J.P. and Samson, J. (2004) Implant stability measurement of delayed and immediately loaded implants during healing. Clin Oral Implants Res 15: 529–539.
- Branemark, P., Zarb, G. and Albrektsson, T. (1985) Tissue Integrated Prostheses: Osseointegration in Clinical Dentistry. Quintessence Publishing, Chicago.
- Branemark, P.I., Hansson, B.O., Adell, R., et al. (1977) Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 16: 1–132.
- Branemark, R. and Skalak, R. (1998) An in-vivo method for biomechanical characterization of boneanchored implants. Med Eng Phys 20: 216–219.
- Branemark, R., Ohrnell, L.O., Skalak, R., Carlsson, L. and Branemark, P.I. (1998) Biomechanical characterization of osseointegration: an experimental in vivo investigation in the beagle dog. J Orthop Res 16: 61–69.
-
Brunette, D., Tengvall, P., Textor, M. and Thomsen, P. (2001) Titanium in Medicine. Springer, Berlin Heidelberg New York.
10.1007/978-3-642-56486-4 Google Scholar
- Brunski, J.B., Moccia, A.F., Jr., Pollack, S.R., Korostoff, E. and Trachtenberg, D.I. (1979) The influence of functional use of endosseous dental implants on the tissue-implant interface I. Histological aspects. J Dent Res 58: 1953–1969.
- Brunski, J.B., Puleo, D.A. and Nanci, A. (2000) Biomaterials and biomechanics of oral and maxillofacial implants: current status and future developments. Int J Oral Maxillofac Implants 15: 15–46.
- Buser, D., Broggini, N., Wieland, M., et al. (2004) Enhanced bone apposition to a chemically modified sla titanium surface. J Dent Res 83: 529–533.
- Buser, D., Schenk, R.K., Steinemann, S., Fiorellini, J.P., Fox, C.H. and Stich, H. (1991) Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res 25: 889–902.
- Buser, D., Weber, H.P. and Lang, N.P. (1990) Tissue integration of non-submerged implants. 1-year results of a prospective study with 100 ITI hollow-cylinder and hollow-screw implants. Clin Oral Implants Res 1: 33–40.
- Buser, D., Weber, H.P., Donath, K., Fiorellini, J.P., Paquette, D.W. and Williams, R.C. (1992) Soft tissue reactions to non-submerged unloaded titanium implants in beagle dogs. J Periodontol 63: 225–235.
- Calandriello, R., Tomatis, M., Vallone, R., Rangert, B. and Gottlow, J. (2003) Immediate occlusal loading of single lower molars using branemark system wide-platform tiunite implants: an interim report of a prospective open-ended clinical multicenter study. Clin Implant Dent Relat Res 5 Suppl 1: 74–80.
- Carlsson, L., Rostlund, T., Albrektsson, B. and Albrektsson, T. (1988) Removal torques for polished and rough titanium implants. Int J Oral Maxillofac Implants 3: 21–24.
- Carter, D. and Giori, N.E. (1991) Effect of mechanical stress on tissue differentiation in the bony implant bed. In: J. Davies, ed. The Bone-Biomaterial Interface, p. 367. University of Toronto Press, Toronto.
- Chang, P.C., Lang, N.P. and Giannobile, W.V. (2010) Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clin Oral Implants Res 21: 1–12.
- Chiapasco, M. and Gatti, C. (2003) Implant-retained mandibular overdentures with immediate loading: a 3- to 8-year prospective study on 328 implants. Clin Implant Dent Relat Res 5: 29–38.
- Chiapasco, M., Abati, S., Romeo, E. and Vogel, G. (2001) Implant-retained mandibular overdentures with branemark system mkii implants: a prospective comparative study between delayed and immediate loading. Int J Oral Maxillofac Implants 16: 537–546.
- Chiapasco, M., Gatti, C., Rossi, E., Haefliger, W. and Markwalder, T.H. (1997) Implant-retained mandibular overdentures with immediate loading. A retrospective multicenter study on 226 consecutive cases. Clin Oral Implants Res 8: 48–57.
- Cochran, D., Oates, T., Morton, D., Jones, A., Buser, D. and Peters, F. (2007) Clinical field trial examining an implant with a sand-blasted, acid-etched surface. J Periodontol 78: 974–982.
- Cochran, D.L., Morton, D. and Weber, H.P. (2004) Consensus statements and recommended clinical procedures regarding loading protocols for endosseous dental implants. Int J Oral Maxillofac Implants 19 Suppl: 109–113.
- Cochran, D.L. (1999) A comparison of endosseous dental implant surfaces. J Periodontol 70: 1523–1539.
- Cochran, D.L., Hermann, J.S., Schenk, R.K., Higginbottom, F.L. and Buser, D. (1997) Biologic width around titanium implants. A histometric analysis of the implanto-gingival junction around unloaded and loaded nonsubmerged implants in the canine mandible. J Periodontol 68: 186–198.
-
Cochran, D.L., Schenk, R.K., Lussi, A., Higginbottom, F.L. and Buser, D. (1998) Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res 40: 1–11.
10.1002/(SICI)1097-4636(199804)40:1<1::AID-JBM1>3.0.CO;2-Q CAS PubMed Web of Science® Google Scholar
- Colnot, C., Romero, D.M., Huang, S., et al. (2007) Molecular analysis of healing at a bone-implant interface. J Dent Res 86: 862–867.
- Cooper, L.F., Ellner, S., Moriarty, J., et al. (2007) Three-year evaluation of single-tooth implants restored 3 weeks after 1-stage surgery. Int J Oral Maxillofac Implants 22: 791–800.
- Davies, J.E. (1998) Mechanisms of endosseous integration. Int J Prosthodont 11: 391–401.
- Derhami, K., Wolfaardt, J.F., Faulkner, G. and Grace, M. (1995) Assessment of the periotest device in baseline mobility measurements of craniofacial implants. Int J Oral Maxillofac Implants 10: 221–229.
- Drago, C.J. (2000) A prospective study to assess osseointegration of dental endosseous implants with the periotest instrument. Int J Oral Maxillofac Implants 15: 389–395.
- Draper, H. (1994) Bone Loss in Animals. Advances in Nutritional Research. New York. Plenum Press.
- Ericsson, I., Johansson, C.B., Bystedt, H. and Norton, M.R. (1994) A histomorphometric evaluation of bone-to-implant contact on machine-prepared and roughened titanium dental implants. A pilot study in the dog. Clin Oral Implants Res 5: 202–206.
- Eriksson, A.R., Albrektsson, T. and Albrektsson, B. (1984) Heat caused by drilling cortical bone. Temperature measured in vivo in patients and animals. Acta Orthop Scand 55: 629–631.
- Evans, G.H., Mendez, A.J. and Caudill, R.F. (1996) Loaded and nonloaded titanium versus hydroxyapatitecoated threaded implants in the canine mandible. Int J Oral Maxillofac Implants 11: 360–371.
- Faulkner, M.G., Giannitsios, D., Lipsett, A.W. and Wolfaardt, J.F. (2001) The use and abuse of the periotest for 2-piece implant/abutment systems. Int J Oral Maxillofac Implants 16: 486–494.
- Friberg, B., Jisander, S., Widmark, G., et al. (2003) One-year prospective three-center study comparing the outcome of a ‘soft bone implant' (prototype mk iv) and the standard branemark implant. Clin Implant Dent Relat Res 5: 71–77.
- Friberg, B., Sennerby, L., Grondahl, K., Bergstrom, C., Back, T. and Lekholm, U. (1999) On cutting torque measurements during implant placement: a 3-year clinical prospective study. Clin Implant Dent Relat Res 1: 75–83.
- Fischer, K., Backstrom, M. and Sennerby, L. (2009) Immediate and early loading of oxidized tapered implants in the partially edentulous maxilla: a 1-year prospective clinical, radiographic, and resonance frequency analysis study. Clin Implant Dent Relat Res 11: 69–80.
- Friberg, B., Sennerby, L., Linden, B., Grondahl, K. and Lekholm, U. (1999) Stability measurements of one-stage branemark implants during healing in mandibles. A clinical resonance frequency analysis study. Int J Oral Maxillofac Surg 28: 266–272.
- Friberg, B., Sennerby, L., Meredith, N. and Lekholm, U. (1999) A comparison between cutting torque and resonance frequency measurements of maxillary implants. A 20-month clinical study. Int J Oral Maxillofac Surg 28: 297–303.
- Frost, H.M. (2000) The Utah paradigm of skeletal physiology: an overview of its insights for bone, cartilage and collagenous tissue organs. J Bone Miner Metab 18: 305–316.
- Gallucci, G.O., Morton, D. and Weber, H.P. (2009) Loading protocols for dental implants in edentulous patients. Int J Oral Maxillofac Implants 24 Suppl: 132–146.
- Gatti, C., Haefliger, W. and Chiapasco, M. (2000) Implant-retained mandibular overdentures with immediate loading: a prospective study of ITI implants. Int J Oral Maxillofac Implants 15: 383–388.
- Glauser, R., Sennerby, L., Meredith, N., et al. (2004) Resonance frequency analysis of implants subjected to immediate or early functional occlusal loading. Successful vs. failing implants. Clin Oral Implants Res 15: 428–434.
- Gotfredsen, K., Wennerberg, A., Johansson, C., Skovgaard, L.T. and Hjorting-Hansen, E. (1995) Anchorage of tio2-blasted, ha-coated, and machined implants: an experimental study with rabbits. J Biomed Mater Res 29: 1223–1231.
- Gottlander, M., Johansson, C.B. and Albrektsson, T. (1997) Short- and long-term animal studies with a plasma-sprayed calcium phosphate-coated implant. Clin Oral Implants Res 8: 345–351.
- Gottlow, J., Dard, M., Kjellson, F., Obrecht, M. and Sennerby, L. (2010) Evaluation of a new titaniumzirconium dental implant: a biomechanical and histological comparative study in the mini pig. Clin Implant Dent Relat Res, June [Epub ahead of print].
- Gould, T.R., Brunette, D.M. and Westbury, L. (1981) The attachment mechanism of epithelial cells to titanium in vitro. J Periodontal Res 16: 611–616.
- Gould, T.R., Westbury, L. and Brunette, D.M. (1984) Ultrastructural study of the attachment of human gingiva to titanium in vivo. J Prosthet Dent 52: 418–420.
- Greenfield, E. (1913) Implantation of artificial crown and bridge abutments. Dental Cosmos 55: 364–369.
- Haas, R., Bernhart, T., Dortbudak, O. and Mailath, G. (1999) Experimental study of the damping behaviour of imz implants. J Oral Rehabil 26: 19–24.
- Hermann, J.S., Buser, D., Schenk, R.K., Higginbottom, F.L. and Cochran, D.L. (2000) Biologic width around titanium implants. A physiologically formed and stable dimension over time. Clin Oral Implants Res 11: 1–11.
- Haas, R., Saba, M., Mensdorff-Pouilly, N. and Mailath, G. (1995) Examination of the damping behavior of imz implants. Int J Oral Maxillofac Implants 10: 410–414.
- Hermann, J.S., Buser, D., Schenk, R.K., Schoolfield, J.D. and Cochran, D.L. (2001) Biologic width around one- and two-piece titanium implants. Clin Oral Implants Res 12: 559–571.
-
Ikarashi, J., Obayashi E., Oi H., et al. (2005) Improved biocompatibility of titanium-zirconium (ti-zr) alloy: tissue reaction and sensitization to ti-zr alloy compared with pure ti and zr in rat implantation study. Mater Trans 46: 7.
10.2320/matertrans.46.2260 Google Scholar
- Ivanoff, C.J., Sennerby, L. and Lekholm, U. (1997) Reintegration of mobilized titanium implants. An experimental study in rabbit tibia. Int J Oral Maxillofac Surg 26: 310–315.
- James, R.A. (1979) The support system and pergingival mechanisms surrounding oral implants. Biomater Med Devices Artif Organs 7: 147–153.
- Johansson, B., Back, T. and Hirsch, J.M. (2004) Cutting torque measurements in conjunction with implant placement in grafted and nongrafted maxillas as an objective evaluation of bone density: a possible method for identifying early implant failures? Clin Implant Dent Relat Res 6: 9–15.
- Johansson, C. and Albrektsson, T. (1987) Integration of screw implants in the rabbit: a 1-year follow-up of removal torque of titanium implants. Int J Oral Maxillofac Implants 2: 69–75.
- Johansson, C.B., Sennerby, L. and Albrektsson, T. (1991) A removal torque and histomorphometric study of bone tissue reactions to commercially pure titanium and vitallium implants. Int J Oral Maxillofac Implants 6: 437–441.
- Lang, N.P., Salvi, G.E., Huynh-Ba, G., Ivanovski, S., Donos, N. and Bosshardt, D.D. (2011) Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clinical Oral Implants Research 22(4): 349–356.
- Lachmann, S., Laval, J.Y., Jager, B., et al. (2006) Resonance frequency analysis and damping capacity assessment. Part 2: Peri-implant bone loss follow-up. An in vitro study with the periotest and osstell instruments. Clin Oral Implants Res 17: 80–84.
- Ledermann, P. (1979) Bar-prosthetic management of the edentulous mandible by means of plasma-coated implantation with titanium screws. Dtsch Zahnarztl Z 34: 907–911.
- Lekholm, U. and Zarb, G. (1985) Patient selection and preparation. In: P. Branemark, G. Zarb and T. Albrektsson, eds. Tissue-Integrated Prostheses: Osseointegration in Clinical Dentistry, pp. 199–209. Quintessence Publishing, Chicago.
- Liljenberg, B., Gualini, F., Berglundh, T., Tonetti, M. and Lindhe, J. (1996) Some characteristics of the ridge mucosa before and after implant installation. A prospective study in humans. J Clin Periodontol 23: 1008–1013.
- Lindhe, J. and Berglundh, T. (1998) The interface between the mucosa and the implant. Periodontol 17: 47–54.
- Linkow, L.I. and Rinaldi, A.W. (1988) Evolution of the vent-plant osseointegrated compatible implant system. Int J Oral Maxillofac Implants 3: 109–122.
- Lioubavina-Hack, N., Lang, N.P. and Karring, T. (2006) Significance of primary stability for osseointegration of dental implants. Clin Oral Implants Res 17: 244–250.
- Listgarten, M.A. and Lai, C.H. (1975) Ultrastructure of the intact interface between an endosseous epoxy resin dental implant and the host tissues. J Biol Buccale 3: 13–28.
- Listgarten, M.A., Buser, D., Steinemann, S.G., Donath, K., Lang, N.P. and Weber, H.P. (1992) Light and transmission electron microscopy of the intact interfaces between non-submerged titanium-coated epoxy resin implants and bone or gingiva. J Dent Res 71: 364–371.
- Listgarten, M.A., Lang, N.P., Schroeder, H.E. and Schroeder, A. (1991) Periodontal tissues and their counterparts around endosseous implants.] Clin Oral Implants Res 2: 1–19.
- Lukas, D. and Schulte, W. (1990) Periotest – a dynamic procedure for the diagnosis of the human periodontium. Clin Phys Physiol Meas 11: 65–75.
- Marzola, R., Scotti, R., Fazi, G. and Schincaglia, G.P. (2007) Immediate loading of two implants supporting a ball attachment-retained mandibular overdenture: a prospective clinical study. Clin Implant Dent Relat Res 9: 136–143.
- Meffert, R.M., Block, M.S. and Kent, J.N. (1987) What is osseointegration? Int J Periodont Restor Dent 7: 9–21.
- Meredith, N. (1998) Assessment of implant stability as a prognostic determinant. Int J Prosthodont 11: 491–501.
- Meredith, N., Alleyne, D. and Cawley, P. (1996) Quantitative determination of the stability of the implanttissue interface using resonance frequency analysis. Clin Oral Implants Res 7: 261–267.
- Meredith, N., Book, K., Friberg, B., Jemt, T. and Sennerby, L. (1997) Resonance frequency measurements of implant stability in vivo. A cross-sectional and longitudinal study of resonance frequency measurements on implants in the edentulous and partially dentate maxilla. Clin Oral Implants Res 8: 226–233.
- Meredith, N., Cawley, P. and Alleyne, D. (1994) The application of modal vibration analysis to study bone healing in vivo. J Dent Res 73: 793.
- Mericske-Stern, R., Milani, D., Mericske, E. and Olah, A. (1995) Periotest measurements and osseointegration of mandibular ITI implants supporting overdentures. A one-year longitudinal study. Clin Oral Implants Res 6: 73–82.
- Misch, C. (2007) Contemporary Implant Dentistry, 3rd edn. Elsevier Health Sciences, Missouri.
- Molly, L. (2006) Bone density and primary stability in implant therapy. Clin Oral Implants Res 17 Suppl 2: 124–135.
- Moon, I.S., Berglundh, T., Abrahamsson, I., Linder, E. and Lindhe, J. (1999) The barrier between the keratinized mucosa and the dental implant. An experimental study in the dog. J Clin Periodontol 26: 658–663.
- Morris, H.E., Ochi, S., Crum, P., Orenstein, I. and Plezia, R. (2003) Bone density: its influence on implant stability after uncovering. J Oral Implantol 29: 263–269.
- Naert, I., Alsaadi, G., van Steenberghe, D. and Quirynen, M. (2004) A 10-year randomized clinical trial on the influence of splinted and unsplinted oral implants retaining mandibular overdentures: peri-implant outcome. Int J Oral Maxillofac Implants 19: 695–702.
- Nedir, R., Bischof, M., Szmukler-Moncler, S., Bernard, J.P. and Samson, J. (2004) Predicting osseointegration by means of implant primary stability. Clin Oral Implants Res 15: 520–528.
-
Neukam, F.W. and Flemmig, T.F. (2006) Local and systemic conditions potentially compromising osseointegration. Consensus report of working group 3. Clin Oral Implants Res 17 Suppl 2: 160–162.
10.1111/j.1600-0501.2006.01359.x Google Scholar
- O'Sullivan, D., Sennerby, L., Jagger, D. and Meredith, N. (2004) A comparison of two methods of enhancing implant primary stability. Clin Implant Dent Relat Res 6: 48–57.
- Ottoni, J.M., Oliveira, Z.F., Mansini, R. and Cabral, A.M. (2005) Correlation between placement torque and survival of single-tooth implants. Int J Oral Maxillofac Implants 20: 769–776.
- Olive, J. and Aparicio, C. (1990) Periotest method as a measure of osseointegrated oral implant stability. Int J Oral Maxillofac Implants 5: 390–400.
- Pendegrass, C.J., Gordon, D., Middleton, C.A., Sun, S.N. and Blunn, G.W. (2008) Sealing the skin barrier around transcutaneous implants: in vitro study of keratinocyte proliferation and adhesion in response to surface modifications of titanium alloy. J Bone Joint Surg Br 90: 114–121.
- Piattelli, A., Scarano, A., Balleri, P. and Favero, G.A. (1998) Clinical and histologic evaluation of an active ‘implant periapical lesion': a case report. Int J Oral Maxillofac Implants 13: 713–716.
- Piattelli, A., Paolantonio, M., Corigliano, M. and Scarano, A. (1997) Immediate loading of titanium plasmasprayed screw-shaped implants in man: a clinical and histological report of two cases. J Periodontol 68: 591–597.
- Piattelli, A., Ruggeri, A., Franchi, M., Romasco, N. and Trisi, P. (1993) An histologic and histomorphometric study of bone reactions to unloaded and loaded non-submerged single implants in monkeys: a pilot study. J Oral Implantol 19: 314–320.
- Pilliar, R.M., Lee, J.M. and Maniatopoulos, C. (1986) Observations on the effect of movement on bone in growth into porous-surfaced implants. Clin Orthop Relat Res July(208): 108–113.
- Raghavendra, S., Wood, M.C. and Taylor, T.D. (2005) Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants 20: 425–431.
- Ring, M.E. (1995) A thousand years of dental implants: a definitive history – part 1. Compend Contin Educ Dent 16: 1060, 1062, 1064 passim.
- Ring, M.E. (1995) A thousand years of dental implants: a definitive history – part 2. Compend Contin Educ Dent 16: 1132, 1134, 1136 passim.
- Roccuzzo, M., Aglietta, M., Bunino, M. and Bonino, L. (2008) Early loading of sandblasted and acid-etched implants: a randomized-controlled double-blind split-mouth study. Five-year results. Clin Oral Implants Res 19: 148–152.
- Romeo, E., Chiapasco, M., Lazza, A.,et al. (2002) Implant-retained mandibular overdentures with ITI implants. Clin Oral Implants Res 13: 495–501.
- Salonen, M.A., Raustia, A.M., Kainulainen, V. and Oikarinen, K.S. (1997) Factors related to periotest values in endosseal implants: a 9-year follow-up. J Clin Periodontol 24: 272–277.
- Salvi, G.E., Gallini, G. and Lang, N.P. (2004) Early loading (2 or 6 weeks) of sandblasted and acid-etched (sla) ITI implants in the posterior mandible. A 1-year randomized controlled clinical trial. Clin Oral Implants Res 15: 142–149.
- Schmid, J., Wallkamm, B., Hammerle, C.H., Gogolewski, S. and Lang, N.P. (1997) The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implants Res 8: 244–248.
- Schroeder, A., Pohler, O. and Sutter, F. (1976) Tissue reaction to an implant of a titanium hollow cylinder with a titanium surface spray layer. SSO Schweiz Monatsschr Zahnheilkd 86: 713–727.
- Schroeder, A., van der Zypen, E., Stich, H. and Sutter, F. (1981) The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg 9: 15–25.
- Schupbach, P. and Glauser, R. (2007) The defense architecture of the human periimplant mucosa: a histological study. J Prosthet Dent 97: S15–25.
- Schulte, W. and Lukas, D. (1992) The periotest method. Int Dent J 42: 433–440.
- Schulte, W. and Lukas, D. (1993) Periotest to monitor osseointegration and to check the occlusion in oral implantology. J Oral Implantol 19: 23–32.
- Schwarz, F., Ferrari, D., Herten, M., et al. (2007a) Effects of surface hydrophilicity and microtopography on early stages of soft and hard tissue integration at non-submerged titanium implants: an immunohistochemical study in dogs. J Periodontol 78: 2171–2184.
- Schwarz, F., Herten, M., Sager, M., Wieland, M., Dard, M. and Becker, J. (2007b) Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional sla titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res 18: 481–488.
- Sennerby, L. and Meredith, N. (2008) Implant stability measurements using resonance frequency analysis: biological and biomechanical aspects and clinical implications. Periodontol 47: 51–66.
- Sennerby, L. and Roos, J. (1998) Surgical determinants of clinical success of osseointegrated oral implants: a review of the literature. Int J Prosthodont 11: 408–420.
- Sennerby, L., Thomsen, P. and Ericson, L.E. (1992) A morphometric and biomechanic comparison of titanium implants inserted in rabbit cortical and cancellous bone. Int J Oral Maxillofac Implants 7: 62–71.
- Sennerby, L., Persson, L.G., Berglundh, T., Wennerberg, A. and Lindhe, J. (2005) Implant stability during initiation and resolution of experimental periimplantitis: an experimental study in the dog. Clin Implant Dent Relat Res 7: 136–140.
- Seong, W.J., Conrad, H.J. and Hinrichs, J.E. (2009) Potential damage to bone-implant interface when measuring initial implant stability. J Periodontol 80: 1868–1874.
- Sjostrom, M., Lundgren, S., Nilson, H. and Sennerby, L. (2005) Monitoring of implant stability in grafted bone using resonance frequency analysis. A clinical study from implant placement to 6 months of loading. Int J Oral Maxillofac Surg 34: 45–51.
- Slaets, E., Carmeliet, G., Naert, I. and Duyck, J. (2007) Early trabecular bone healing around titanium implants: a histologic study in rabbits. J Periodontol 78: 510–517.
-
Steflik, D.E., Corpe, R.S., Lake, F.T., et al. (1998) Ultrastructural analyses of the attachment (bonding) zone between bone and implanted biomaterials. J Biomed Mater Res 39: 611–620.
10.1002/(SICI)1097-4636(19980315)39:4<611::AID-JBM16>3.0.CO;2-9 CAS PubMed Web of Science® Google Scholar
- Steflik, D.E., Hanes, P.J., Sisk, A.L., et al. (1992) Transmission electron microscopic and high voltage electron microscopic observations of the bone and osteocyte activity adjacent to unloaded dental implants placed in dogs. J Periodontol 63: 443–452.
- Steflik, D.E., McKinney, R.V., Sisk, A.L., Koth, D.L., Singh, B.B. and Parr, G.R. (1990) Ultrastructural investigations of the bone and fibrous connective tissue interface with endosteal dental implants. Scanning Microsc 4: 1039–1047; discussion on 1047–1038.
- Steflik, D.E., Parr, G.R., Sisk, A.L., Hanes, P.J. and Lake, F.T. (1992) Electron microscopy of bone response to titanium cylindrical screw-type endosseous dental implants. Int J Oral Maxillofac Implants 7: 497–507.
- Steflik, D.E., Sisk, A.L., Parr, G.A., Lake, F.T. and Hanes, P.J. (1993) Experimental studies of the implanttissue interface. J Oral Implantol 19: 90–94; discussion 136–137.
- Steinemann, S.G. (1998) Titanium – the material of choice? Periodontol 17: 7–21.
- Stephan, G., Vidot, F., Noharet, R. and Mariani, P. (2007) Implant-retained mandibular overdentures: a comparative pilot study of immediate loading versus delayed loading after two years. J Prosthet Dent 97: S138–145.
- Stricker, A., Gutwald, R., Schmelzeisen, R. and Gellrich, N.G. (2004) Immediate loading of 2 interforaminal dental implants supporting an overdenture: clinical and radiographic results after 24 months. Int J Oral Maxillofac Implants 19: 868–872.
- Sullivan, D.Y., Sherwood, R.L., Collins, T.A. and Krogh, P.H. (1996) The reverse-torque test: a clinical report. Int J Oral Maxillofac Implants 11: 179–185.
- Szmukler-Moncler, S., Piattelli, A., Favero, G.A. and Dubruille, J.H. (2000) Considerations preliminary to the application of early and immediate loading protocols in dental implantology. Clin Oral Implants Res 11: 12–25.
- Tawse-Smith, A., Perio, C., Payne, A.G., Kumara, R. and Thomson, W.M. (2001) One-stage operative procedure using two different implant systems: a prospective study on implant overdentures in the edentulous mandible. Clin Implant Dent Relat Res 3: 185–193.
- Testori, T., Szmukler-Moncler, S., Francetti, L., et al. (2001) Immediate loading of osseotite implants: a case report and histologic analysis after 4 months of occlusal loading. Int J Periodontics Restorative Dent 21: 451–459.
- Tjellstrom, A., Jacobsson, M. and Albrektsson, T. (1988) Removal torque of osseointegrated craniofacial implants: a clinical study. Int J Oral Maxillofac Implants 3: 287–289.
- Truhlar, R.S., Lauciello, F., Morris, H.F. and Ochi, S. (1997) The influence of bone quality on periotest values of endosseous dental implants at stage II surgery. J Oral Maxillofac Surg 55: 55–61.
- Truhlar, R.S., Morris, H.F., Ochi, S. and Winkler, S. (1994) Second-stage failures related to bone quality in patients receiving endosseous dental implants: DICRG interim report no. 7. Dental Implant Clinical Research Group. Implant Dent 3: 252–255.
- Tsuchiya, T., Nakamura, A., Ohshima, Y., et al. (1998) Chondrogenic cellular responses to titanium and zirconium alloys in vitro. Tissue Eng 4: 197–192–194.
- Turkyilmaz, I., Sennerby, L., Tumer, C., Yenigul, M. and Avci, M. (2006) Stability and marginal bone level measurements of unsplinted implants used for mandibular overdentures: a 1-year randomized prospective clinical study comparing early and conventional loading protocols. Clin Oral Implants Res 17: 501–505.
- Thomas, K.A. and Cook, S.D. (1985) An evaluation of variables influencing implant fixation by direct bone apposition. J Biomed Mater Res 19: 875–901.
- Ueda, M., Matsuki, M., Jacobsson, M. and Tjellstrom, A. (1991) Relationship between insertion torque and removal torque analyzed in fresh temporal bone. Int J Oral Maxillofac Implants 6: 442–447.
- Van Steenberghe, D., Tricio, J., Naert, I. and Nys, M. (1995) Damping characteristics of bone-to-implant interfaces. A clinical study with the periotest device. Clin Oral Implants Res 6: 31–39.
- Vandamme, K., Naert, I., Geris, L., Vander Sloten, J., Puers, R. and Duyck, J. (2007) The effect of micro-motion on the tissue response around immediately loaded roughened titanium implants in the rabbit. Eur J Oral Sci 115: 21–29.
- Verhoeven, J.W., Cune, M.S. and de Putter, C. (2000) Reliability of some clinical parameters of evaluation in implant dentistry. J Oral Rehabil 27: 211–216.
- Vignoletti, F., Johansson, C., Albrektsson, T., De Sanctis, M., San Roman, F. and Sanz, M. (2009) Early healing of implants placed into fresh extraction sockets: an experimental study in the beagle dog. De novo bone formation. J Clin Periodontol 36: 265–277.
- Weber, H.P., Morton, D., Gallucci, G.O., Roccuzzo, M., Cordaro, L. and Grutter, L. (2009) Consensus statements and recommended clinical procedures regarding loading protocols. Int J Oral Maxillofac Implants 24 Suppl: 180–183.
- Wennerberg, A. and Albrektsson, T. (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Implants Res 20 Suppl 4: 172–184.
- Wennerberg, A., Albrektsson, T., Andersson, B. and Krol, J.J. (1995) A histomorphometric and removal torque study of screw-shaped titanium implants with three different surface topographies. Clin Oral Implants Res 6: 24–30.
- Wong, M., Eulenberger, J., Schenk, R. and Hunziker, E. (1995) Effect of surface topology on the osseointegration of implant materials in trabecular bone. J Biomed Mater Res 29: 1567–1575.
