Chapter 42
Disinfection and Sterilization
Book Editor(s):Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci,
Anna S.F. Lok MD,
Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath,
Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci,
Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci
Emeritus Professor of Hepatology, Department of Medicine, Imperial College London, London, UK
Search for more papers by this authorAnna S.F. Lok MD
Alice Lohrman Andrews Research Professor in Hepatology, Director of Clinical Hepatology, Professor of Internal Medicine, Associate Chair for Clinical Research, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Search for more papers by this authorStephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath
Head, Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia
Search for more papers by this authorArie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci
Emeritus Professor of Medical Microbiology, Formerly Principal and Dean, Royal Free Hospital School of Medicine
Search for more papers by this authorFirst published: 26 July 2013
Summary
Effective methods for disinfection and sterilization of pathogenic microbes are essential in healthcare settings, including the laboratory and environmental surfaces. The available methods, as well as methods for decontamination, are reviewed with particular emphasis on the hepatitis viruses. These processes are defined, and a number of physical and chemical methods are described for inactivating the hepatitis viruses. While the resistance of each of the individual species of the hepatitis viruses to heat and chemical reagents varies, none exceeds the level of resistance of bacterial spores or M.tuberculosis so that conventional procedures can be employed, including application to medical devices.
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