Chapter 11
Extrahepatic Manifestations of Hepatitis B Infection
Christian Trépo,
Majid Amiri,
Loïc Guillevin,
Christian Trépo
Service d’HépatoGastroentérologie, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France
Search for more papers by this authorMajid Amiri
Centre de Recherche en Cancérologie de Lyon, Lyon, France
Search for more papers by this authorLoïc Guillevin
Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Université Paris-Descartes, Paris, France
Search for more papers by this authorChristian Trépo,
Majid Amiri,
Loïc Guillevin,
Christian Trépo
Service d’HépatoGastroentérologie, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France
Search for more papers by this authorMajid Amiri
Centre de Recherche en Cancérologie de Lyon, Lyon, France
Search for more papers by this authorLoïc Guillevin
Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Université Paris-Descartes, Paris, France
Search for more papers by this authorBook Editor(s):Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci,
Anna S.F. Lok MD,
Stephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath,
Arie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci,
Howard C. Thomas BSc, PhD, FRCP, FRCPath, FMedSci
Emeritus Professor of Hepatology, Department of Medicine, Imperial College London, London, UK
Search for more papers by this authorAnna S.F. Lok MD
Alice Lohrman Andrews Research Professor in Hepatology, Director of Clinical Hepatology, Professor of Internal Medicine, Associate Chair for Clinical Research, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, USA
Search for more papers by this authorStephen A. Locarnini MBBS, BSc(Hons), PhD, FRCPath
Head, Research & Molecular Development, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC, Australia
Search for more papers by this authorArie J. Zuckerman MD, DSc, FRCP, FRCPath, FMedSci
Emeritus Professor of Medical Microbiology, Formerly Principal and Dean, Royal Free Hospital School of Medicine
Search for more papers by this authorSummary
Hepatitis B (HBV) and hepatitis C (HCV) viruses are well-recognized causes of chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Apart from liver disease, these viral infections are known to be associated with a wide spectrum of extrahepatic manifestations, including polyarteritis nodosa (PAN) and vasculitis, glomerulonephritis, and cutaneous, neurological, and hematological complications. The prevalence of clinically significant extrahepatic manifestations is relatively low, but it can be associated with significant morbidity and even mortality. An awareness and recognition of these manifestations are of paramount importance in facilitating early diagnosis and in offering treatment. Such treatments may be highly successful, as for HBV-related PAN and glomerulonephritis, but in some cases treatment may be unsuccessful and the infection may continue with disabling extrahepatic manifestations.
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