Hereditary Urogenital Cancer Syndromes
Summary
Urogenital malignancies are in the cancer spectra of multiple hereditary cancer syndromes. Some diagnoses are strongly associated with inherited risks for cancer, while others are less predictive of a mutation. This chapter utilizes case presentations to emphasize the importance of personal and family histories in cancer genetics risk assessments, explores some of the challenges and uncertainties associated with genetic counseling and testing, and highlights selected controversies in urogenital cancer genetics.