Nanotissue Engineering of Skin Cells
Daisy M. Ramos
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Materials Science and Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorAditi Subramanian
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorAja Aravamudhan
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorMatthew Harmon
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Materials Science and Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorRoshan James
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorNamdev B. Shelke
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorSangamesh G. Kumbar
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Farmington, CT, USA
Search for more papers by this authorDaisy M. Ramos
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Materials Science and Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorAditi Subramanian
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorAja Aravamudhan
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorMatthew Harmon
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Materials Science and Engineering, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorRoshan James
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorNamdev B. Shelke
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Search for more papers by this authorSangamesh G. Kumbar
Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT, USA
Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT, USA
Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT, USA
Department of Chemical, Materials and Biomolecular Engineering, University of Connecticut, Farmington, CT, USA
Search for more papers by this authorHossein Baharvand
Search for more papers by this authorNasser Aghdami
Search for more papers by this authorSummary
Playing the role as the largest organ in the body, the skin serves as a protective shield. Since the 1860s when combating dermal wounds, many options have been addressed to assist in the healing process. Current limitations with existing treatments, such as autographs and allographs have propelled research towards tissue engineering for skin tissue regeneration. Tissue-engineering techniques bring advancement in the treatment of acute and chronic wounds through the use of stem cells, biomaterials, and biological factors. Strategies for skin tissue engineering involve emulating the physical and biochemical environment of native tissue through the use of a synthetic extracellular matrix or scaffold. The scaffold provides an initial substrate for cell attachment and serves as a wound dressing to combat infection. Material selection and choice of fabrication technique play a role in the chemical and topographical make-up of the scaffold, which ultimately affect cell behavior. The present review elaborates on the types of stem cells used for skin tissue engineering, discusses natural and synthetic polymers used to create scaffolds, and highlights the relevance of electrospun nanofibers in providing nanotopographical cues and bioactivity.
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