Chapter 111

Vascular Diseases of the Liver

Susana Seijo

Susana Seijo

Hospital Clínic-Institut de Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

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Laurie D. DeLeve

Laurie D. DeLeve

Keck School of Medicine of USC, Los Angeles, CA, USA

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First published: 27 November 2015

Summary

This chapter provides an overview of vascular diseases of the liver. Several rare diseases are included within this term, the most important being Budd-Chiari syndrome (BCS), portal vein thrombosis (PVT), sinusoidal obstruction syndrome (SOS) and adaptation to heterogenous perfusion. BCS and PVT are mainly caused by prothrombotic diseases and they frequently develop non-cirrhotic portal hypertension-related complications. SOS is caused most often by drugs and chemotherapy regimens and its clinical presentation ranges from asymptomatic to severe hepatic and multiorgan failure. The term adaptation to heterogenous perfusion includes a variety of rare entities such as nodular regenerative hyperplasia, hepatoportal sclerosis, non-cirrhotic portal cirrhosis, and obliterative portal venopathy, suggesting that they could constitute a single entity with a common pathogenic mechanism that results in a spectrum of pathological lesions and clinical manifestations. This chapter also considers ischemic hepatitis, congestive hepatopathy and peliosis hepatis.

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