Chapter 28
Marine Bioactive Peptide Sources: Critical Points and the Potential for New Therapeutics
Ratih Pangestuti,
Se-Kwon Kim,
Ratih Pangestuti
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorSe-Kwon Kim
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorRatih Pangestuti,
Se-Kwon Kim,
Ratih Pangestuti
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorSe-Kwon Kim
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorBook Editor(s):Se-Kwon Kim,
Se-Kwon Kim
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea
Department of Chemistry, Pukyoung National University, Nam-Gu, Busan, Republic of Korea
Search for more papers by this authorSummary
Marine protein and bioactive peptides (BAPs) have gained much attention for their therapeutic effects, such as antihypertensive, antiproliferative, anticoagulant, calcium-binding, anti-obesity and antidiabetic activities. Among the different bioactive proteins and peptides found from marine sources, including enzymes, collagen and gelatin, antifreeze proteins (AFPs), antimicrobials, antioxidants and other BAPs with different bioactivities are found to have a variety of food applications. The production and utilization of marine-derived proteins and peptides not only satisfies the needs of food manufacturers and consumers but also serves as an effective means of utilizing some of the byproducts of the fishing industry. This chapter focuses on the unique features, extraction methods, possible applications and advantages and disadvantages of marine proteins and peptides in order to provide a comprehensive look at these invaluable food ingredients, their future industrial applications and possible directions for further studies.
References
- Aneiros, A., Garateix, A. (2004). Bioactive peptides from marine sources: pharmacological properties and isolation procedures. Journal of Chromatography B, 803, 41–53.
- Berillis, P., Mente, E., Nengas, I. (2011). Collagen fibrils in cultured and wild sea bream (Sparus aurata) liver: an electron microscopy and image analysis study. The Scientific World Journal, 11, 917–929.
- Bogorad, L. (1975). Phycobiliproteins and complementary chromatic adaptation. Annual Review of Plant Physiology, 26, 369–401.
- Boyd, W. C., Shapleigh, E. (1954). Separation of individuals of any blood group into secretors and non-secretors by use of a plant agglutinin (lectin). Blood, 9, 1195–1198.
- Díaz-Miranda, L., García-Arrarás, J. (1995). Pharmacological action of the heptapeptide GFSKLYFamide in the muscle of the sea cucumber Holothuria glaberrima (Echinodermata). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 110, 171–176.
- Díaz-Miranda, L., Price, D. A., Greenberg, M. J., Lee, T. D., Doble, K. E., García-Arrarás, J. E. (1992). Characterization of two novel neuropeptides from the sea cucumber Holothuria glaberrima. The Biological Bulletin, 182, 241–247.
- Fitzgerald, C., Gallagher, E., Tasdemir, D., Hayes, M. (2011). Heart health peptides from macroalgae: isolation and potential use in functional foods. Journal of Agricultural and Food Chemistry, doi:10.1021/jf201114d.
- Glazer, A. N. (1994). Phycobiliproteins—a family of valuable, widely used fluorophores. Journal of Applied Phycology, 6, 105–112.
- Gozes, I. (2001). Neuroprotective peptide drug delivery and development: potential new therapeutics. Trends in Neurosciences, 24, 700–705.
- Gozes, I., Morimoto, B. H., Tiong, J., Fox, A., Sutherland, K., Dangoor, D., Holser-Cochav, M., Vered, K., Newton, P., Aisen, P. S., Matsuoka, Y., van Dyck, C. H., Thal, L. (2005). NAP: Research and Development of a Peptide Derived from Activity-Dependent Neuroprotective Protein (ADNP). CNS Drug Reviews, 11, 353–368.
- Himaya, S., BoMi, R., Zhong-Ji, Q., Li, Y., Kim, S. K. (2011). 1-(5-bromo-2-hydroxy-4-methoxyphenyl) ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signaling pathways in activated microglia. European Journal of Pharmacology.
- Himaya, S., Ryu, B. M., Qian, Z. J., Kim, S. K. (2010). Sea cucumber, Stichopus japonicus ethyl acetate fraction modulates the lipopolysaccharide induced iNOS and COX-2 via MAPK signaling pathway in murine macrophages. Environmental Toxicology and Pharmacology, 30, 68–75.
- Je, J. Y., Park, J. Y., Jung, W. K., Park, P. J., Kim, S. K. (2005a). Isolation of angiotensin I converting enzyme (ACE) inhibitor from fermented oyster sauce, Crassostrea gigas. Food Chemistry, 90, 809–814.
- Je, J. Y., Park, P. J., Byun, H. G., Jung, W. K., Kim, S. K. (2005b). Angiotensin I converting enzyme (ACE) inhibitory peptide derived from the sauce of fermented blue mussel, Mytilus edulis. Bioresource technology, 96, 1624–1629.
- Khan, S. B., Qian, Z. J., Ryu, B. M., Kim, S. K. (2009). Isolation and biochemical characterization of collagens from seaweed pipefish, Syngnathus schlegeli. Biotechnology and Bioprocess Engineering, 14, 436–442.
- Kim, S. K., Mendis, E. (2006). Bioactive compounds from marine processing byproducts: a review. Food Research International, 39, 383–393.
- Kim, S. K., Wijesekara, I. (2010). Development and biological activities of marine-derived bioactive peptides: a review. Journal of Functional Foods, 2, 1–9.
- Lin, Q., Lin, J., Lu, J., Li, B. (2008). Biochemical composition of six seahorse species, Hippocampus sp., from the Chinese coast. Journal of the World Aquaculture Society, 39, 225–234.
- Lin, Q., Lin, J., Wang, C. (2009). Biochemical composition of the wild and cultured seahorses, Hippocampus kuda Bleeker and Hippocampus trimaculatus Leach. Aquaculture Research, 40, 710–719.
- Lourie, S. A., Pritchard, J. C., Casey, S. P., Truong, S. I. K. Y., Hall, H. J., Vincent, A. C. J. (1999). The taxonomy of Vietnam's exploited seahorses (family Syngnathidae). Biological Journal of the Linnean Society, 66, 231–256.
- Matsunaga, S., Fusetani, N., Konosu, S. (1985). Bioactive marine metabolites, IV. Isolation and the amino acid composition of discodermin A, an antimicrobial peptide, from the marine sponge Discodermia kiiensis. Journal of Natural Products, 48, 236–241.
- Müller, W. E. G., Wang, X., Chen, A., Hu, S., Gan, L., Schröder, H. C., Schloßmacher, U., Wiens, M. (2011). The unique invention of the siliceous sponges: their enzymatically made bio-silica skeleton. Molecular Biomineralization, 251–281.
- Pangestuti, R., Kim, S. K. (2011). Biological activities and health benefit effects of natural pigments derived from marine algae. Journal of Functional Foods, 3, 255–266.
- Qian, Z. J., Jung, W. K., Byun, H. G., Kim, S. K. (2008a). Protective effect of an antioxidative peptide purified from gastrointestinal digests of oyster, Crassostrea gigas against free radical induced DNA damage. Bioresource Technology, 99, 3365–3371.
- Qian, Z. J., Ryu, B. M., Kim, M. M., Kim, S. K. (2008b). Free radical and reactive oxygen species scavenging activities of the extracts from seahorse, Hippocampus kuda Bleeler. Biotechnology and Bioprocess Engineering, 13, 705–715.
- Rajapakse, N., Mendis, E., Jung, W. K., Je, J. Y., Kim, S. K. (2005). Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties. Food Research International, 38, 175–182.
- Rogers, D. J., Hori, K. (1993). Marine algal lectins: new developments. Hydrobiologia, 260–261, 589–593.
- Ryu, B. M., Himaya, S., Qian, Z. J., Lee, S. H., Kim, S. K. (2011). Prevention of hydrogen peroxide-induced oxidative stress in HDF cells by peptides derived from seaweed pipefish, Syngnathus schlegeli. Peptides, 32(4), 639–647.
- Ryu, B. M., Qian, Z. J., Kim, S. K. (2010a). Purification of a peptide from seahorse, that inhibits TPA-induced MMP, iNOS and COX-2 expression through MAPK and NF-[kappa] B activation, and induces human osteoblastic and chondrocytic differentiation. Chemico-biological Interactions, 184, 413–422.
- Ryu, B. M., Qian, Z. J., Kim, S. K. (2010b). SHP–1, a novel peptide isolated from seahorse inhibits collagen release through the suppression of collagenases 1 and 3, nitric oxide products regulated by NF-[kappa] B/p38 kinase. Peptides, 31, 79–87.
- Sato, M., Hosokawa, T., Yamaguchi, T., Nakano, T., Muramoto, K., Kahara, T., Funayama, K., Kobayashi, A. (2002). Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. Journal of Agricultural and Food Chemistry, 50, 6245–6252.
- Sekar, S., Chandramohan, M. (2008). Phycobiliproteins as a commodity: trends in applied research, patents and commercialization. Journal of Applied Phycology, 20, 113–136.
- Senaratne, L., Park, P. J., Kim, S. K. (2006). Isolation and characterization of collagen from brown backed toadfish (Lagocephalus gloveri) skin. Bioresource technology, 97, 191–197.
- Shahidi, F. (2008). Bioactives from Marine Resources. ACS Publications, pp. 24–34.
- Shahidi, F., Alasalvar, C. (2011). Marine oils and other marine nutraceuticals. In: Handbook of Seafood Quality, Safety and Health Applications. Wiley Online Library, Chapter 36.
- Shahidi, F., Janak Kamil, Y. (2001). Enzymes from fish and aquatic invertebrates and their application in the food industry. Trends in Food Science & Technology, 12, 435–464.
- Shahidi, F., Zhong, Y. (2008). Bioactive Peptides. Journal of AOAC International, 91, 914–931.
- Shaikh, B. T., Hatcher, J. (2005). Complementary and alternative medicine in Pakistan: prospects and limitations. Evidence Based Complementary and Alternative Medicine, 2, 139–142.
- Silva, L. M. C. M., Lima, V., Holanda, M. L., Pinheiro, P. G., Rodrigues, J. A. G., Lima, M. E. P., Benevides, N. M. B. (2010). Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea. Biological & Pharmaceutical Bulletin, 33, 830–835.
- Sousa, I., Batista, A. P., Raymundo, A., Empis, J. (2006). Rheological characterization of coloured oil-in-water food emulsions with lutein and phycocyanin added to the oil and aqueous phases. Food Hydrocolloids, 20, 44–52.
- Suetsuna, K. (1998). Purification and identification of angiotensin I-converting enzyme inhibitors from the red alga Porphyra yezoensis. Journal of Marine Biotechnology, 6, 163–167.
- Suetsuna, K., Maekawa, K., Chen, J.-R. (2004a). Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. The Journal of Nutritional Biochemistry, 15, 267–272.
- Suetsuna, K., Maekawa, K., Chen, J. R. (2004b). Antihypertensive effects of Undaria pinnatifida (wakame) peptide on blood pressure in spontaneously hypertensive rats. The Journal of Nutritional Biochemistry, 15, 267–272.
- Suetsuna, K., Nakano, T. (2000). Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). The Journal of Nutritional Biochemistry, 11, 450–454.
- Wijesekara, I., Kim, S.-K. (2010). Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: prospects in the pharmaceutical industry. Marine Drugs, 8, 1080–1093.
- Wijesekara, I., Qian, Z. J., Ryu, B. M., Ngo, D. H., Kim, S. K. (2010). Purification and identification of antihypertensive peptides from seaweed pipefish (Syngnathus schlegeli) muscle protein hydrolysate. Food Research International.
- Wijesinghe, W. A. J. P., Jeon, Y. -J. (2011). Enzyme-assistant extraction (EAE) of bioactive components: A useful approach for recovery of industrially important metabolites from seaweeds: A review. Fitoterapia In Press.
- Yabuta, Y., Fujimura, H., Kwak, C. S., Enomoto, T., Watanabe, F. (2010). Antioxidant activity of the phycoerythrobilin compound formed from a dried korean purple laver (Porphyra sp.) during in vitro digestion. Food Science and Technology Research, 16, 347–352.
- Zhang, N., Xu, B., Mou, C., Yang, W., Wei, J., Lu, L., Zhu, J., Du, J., Wu, X., Ye, L., Fu, Z., Lu, Y., Lin, J., Sun, Z., Su, J., Dong, M., Xu, A. (2003). Molecular profile of the unique species of traditional Chinese medicine, Chinese seahorse (Hippocampus kuda Bleeker). FEBS Letters, 550, 124–134.
- Zhao, Y., Li, B., Liu, Z., Dong, S., Zhao, X., Zeng, M. (2007). Antihypertensive effect and purification of an ACE inhibitory peptide from sea cucumber gelatin hydrolysate. Process Biochemistry, 42, 1586–1591.
