Chapter 17
Engineering of Human Tissue Grafts
John N. Kearney BSc, PhD,
Francisco da Costa MD,
John N. Kearney BSc, PhD
Liverpool Blood Centre, NHS Blood and Transplant, Liverpool, UK
University of Leeds, Leeds, UK
Search for more papers by this authorFrancisco da Costa MD
Santa Casa de Curitiba, Pontificia Universida de Catolica do Parana, Curitiba, Brazil
Search for more papers by this authorJohn N. Kearney BSc, PhD,
Francisco da Costa MD,
John N. Kearney BSc, PhD
Liverpool Blood Centre, NHS Blood and Transplant, Liverpool, UK
University of Leeds, Leeds, UK
Search for more papers by this authorFrancisco da Costa MD
Santa Casa de Curitiba, Pontificia Universida de Catolica do Parana, Curitiba, Brazil
Search for more papers by this authorBook Editor(s):Deirdre Fehily PhD,
Scott A. Brubaker CTBS,
John N. Kearney BSc, PhD, CBiol, MIBiol, SRCS,
Lloyd Wolfinbarger Jr. PhD,
Deirdre Fehily PhD
Tissues and Cells, National Transplant Centre, Rome, Italy
Search for more papers by this authorScott A. Brubaker CTBS
American Association of Tissue Banks, McLean, VA, USA
Search for more papers by this authorJohn N. Kearney BSc, PhD, CBiol, MIBiol, SRCS
Liverpool Blood Centre, NHS Blood and Transplant, Liverpool, UK
University of Leeds, Leeds, UK
Search for more papers by this authorFirst published: 13 June 2012
Summary
Many different novel approaches to tissue replacement or tissue regeneration can now be categorized as “tissue engineering.”This includes the use of cultured autologous cells, e.g., keratinocytes or chondrocytes to replace missing tissue. At the other extreme, the decellularization of tissue allografts produces matrices that stimulate regeneration while avoiding immunological rejection responses. Combining both cells and matrices, and conditioning the constructs in bioreactors, takes the technology a stage further. This chapter explores how these methods are being applied to improve the performance of current tissue grafts.
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