Burn injuries are one of the most aggressive lesions that the human body can suffer with certain probabilities of survival. Recent advances on the treatment of critical burn patients have run in parallel with beneficial contributions from different fields of biomedical engineering, ranging from modeling and simulation techniques to tissue engineering to information technologies and communications applied to this life-threatening trauma. The use of mathematical models has led to a better understanding of the physiopathology of the burn patient, and relying on their capabilities for knowledge generation and integration, it has been possible to propose therapies with the quantification of the loss of fluids, electrolytes, and colloids as a function of burn extent and depth and the time interval since the injury. The reconstruction of skin is another challenge for plastic surgeons that has improved by applying tissue engineering concepts. Especially in recent years, the improvement of information technologies and communications has played a fundamental role in improving the quality of the treatment to burn patients, with telemedicine as a clear example.