Chapter 12
Natural History and Pathogenesis of Gallstones
Beat Müllhaupt,
Beat Müllhaupt
Search for more papers by this authorBeat Müllhaupt,
Beat Müllhaupt
Search for more papers by this authorBook Editor(s):Pierre-Alain Clavien MD, PhD, FACS, FRCS,
John Baillie MB, ChB, FRCP, FACG,
Pierre-Alain Clavien MD, PhD, FACS, FRCS
Professor and Chairman, Swiss Hepato-Pancreato-Biliary Center, Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland
Search for more papers by this authorJohn Baillie MB, ChB, FRCP, FACG
Professor of Medicine, Director of Hepatobiliary and Pancreatic Disorder Service, Wake Forest University Health Sciences Center, Winston-Salem, North Carolina, USA
Search for more papers by this authorFirst published: 14 June 2006
Summary
This chapter contains sections titled:
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Introduction
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Types of gallstones
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Pathogenesis of gallstone formation
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Risk factors for gallstone formation
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Natural history of gallstones
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Treatment of gallstones
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Questions
References
- Diehl AK. Epidemiology and natural history of gallstone disease. Gastroenterol Clin North Am 1991; 20: 1–19.
- Proceedingsofthe NIH Consensus Development Conferenceon Gallstonesand Laparoscopic Cholecystectomy. Bethesda, Maryland, September 14–16, 1992. Am J Surg 1993; 165: 387–548.
- Ingelfinger FJ. Digestive disease as a national problem. V. Gallstones. Gastroenterology 1968; 55: 102–4.
- Diehl AK. Cholelithiasis and the insulin resistance syndrome. Hepatology 2000; 31: 528–30.
- Miyake H, Johnston CG. Gallstones: ethnological studies. Digestion 1968; 1: 219–28.
- Busch N, Matern S. Current concepts in cholesterol gallstone pathogenesis. Eur J Clin I nvest 1991; 21: 453–60.
- Paumgartner G, Sauerbruch T. Secretion, composition and fl ow of bile. Clin Gastroenterol 1983; 12: 3–23.
- Paumgartner G, Sauerbruch T. Gallstones: pathogenesis. Lancet 1991; 338: 1117–21.
- Donovan J M, Carey MC. Separation and quantitation of cholesterol “carriers” in bile. Hepatology 1990; 12: 94S–104S; discussion 104S-105S.
- Crawford J M, Mockel GM, Crawford AR, et al. Imaging biliary lipid secretion in the rat: ultrastructural evidence for vesicula-tion of the hepatocyte canalicular membrane. J Lipid Res 1995; 36: 2147–63.
- Holzbach RT, Marsh M, Olszewski M, Holan K. Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J Clin Invest 1973; 52: 1467–79.
- Holan KR, Holzbach RT, Hermann RE, et al. Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology 1979; 77: 611–7.
- Burnstein MJ, Ilson RG, Petrunka CN, et al. Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol gallstones. Gastroenterology 1983; 85: 801–7.
- LaMont JT, Smith BF, Moore JR. Role of gallbladder mucin in pathophysiology of gallstones. Hepatology 1984; 4 (5 Suppl.): 51S–56S.
- Lee SP, Carey MC, LaMont J T. Aspir in prevention of cholesterol gallstone formation in prairie dogs. Science 1981; 211: 1429–31.
- Pazzi P, Scagliarini R, Sighinolfi D, et al. Nonsteroidal antiin-fl ammatory drug use and gallstone d isease prevalence: a case-control study. Am J Gastroenterol 1998; 93: 1420–4.
- Choi J, Klinkspoor JH, Yoshida T, Lee SP. Lipopolysaccharide from Escherichia coli stimulates mucin secretion by cultured dog gallbladder epithelial cells. Hepatology 1999; 29: 1352–7.
- Miquel JF, Nunez L, Amigo L, et al. Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in hu man gallbladder bile. Gastroenterology 1998; 114: 1016–23.
- Pitt H A, Doty JE, DenBesten L. Increased intragallbladder pressure response to cholecystokinin-octapeptide following vagotomy and pyloroplasty. J Surg Res 1983; 35: 325–31.
- Gurll NJ, Meyer PD, DenBesten L. Effect of cholesterol crystals on gallbladder function in cholelithiasis. Surg Forum 1977; 28: 412–3.
- Davis M, Ryan JP. Infl uence of progesterone on gui nea pig ga ll-bladder motility in vitro. Dig Dis Sci 1986; 31: 513–8.
- Everson GT. Gallbladder function in gallstone disease. Gastro-enterol Clin North Am 1991; 20: 85–110.
- Saunders KD, Cates JA, Roslyn JJ. Pathogenesis of gallstones. Surg Clin North Am 1990; 70: 1197–216.
- Cahalane MJ, Neubrand MW, Carey MC. Physical-chemical pathogenesis of pigment gallstones. Semin Liver Dis 1988; 8: 317–28.
- Brink MA, Slors JF, Keulemans YC, et al. Enterohepatic cycling of bilirubin: a putative mechanism for pigment gallstone formation in ileal Crohn's disease. Gastroenterology 1999; 116: 1420–7.
- Cetta F. The role of bacteria in pigment gallstone disease. Ann Surg 1991; 213: 315–26.
- Kaufman HS, Magnuson TH, Lillemoe KD, et al. The role of bacteria in gallbladder and common duct stone formation. Ann Surg 1989; 209: 584–91; discussion 591–2.
- Saharia PC, Zuidema GD, Cameron JL. Primary common duct stones. Ann Surg 1977; 185: 598–604.
- Wong HN, Frey CF, Gagic NM. Intraoperative common duct pressure and fl ow measurements. Am J Surg 1980; 139: 691–5.
- Toouli J, Geenen JE, Hogan WJ, et al. Sphincter of Oddi motor activ ity: a comparison between patients w ith common bile duc t stones a nd controls. Gastroenterology 1982; 82: 111–7.
- De Masi E, Corazziari E, Habib FI, et al. Manometric study of the sphincter of Oddi in patients with and without common bile duc t stones. Gut 1984; 25: 275–8.
- Lotveit T, Skar V, Osnes M. Juxtapapillary duodenal diverticula. Endoscopy 1988; 20 (Suppl. 1): 175–8.
- Nakayama F, Koga A. Hepatolithiasis: present status. World J Surg 1984; 8: 9–14.
- Yamashita N, Yanagisawa J, Nakayama F. Composition of intra-hepatic calculi. Etiological significance. Dig Dis Sci 1988; 33: 449–53.
- Strichartz SD, Abedin MZ, Ippoliti AF, et al. Intrahepatic cholesterol stones: a rationale for dissolution therapy. Gastroenter-ology 1991; 100: 228–32.
- Shoda J, Oda K, Suzuki H, et al. Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi. Hepatology 2001; 33: 1194–205.
- Conrad MR, Janes JO, Dietchy J. Significance of low level echoes within the gallbladder. Am J Roentgenol 1979; 132: 967–72.
- Lee SP, Maher K, Nicholls JF. Origin and fate of biliary sludge. Gastroenterology 1988; 94: 170–6.
- Allen B, Bernhoft R, Blanckaert N, et al. Sludge is calcium bili-rubinate associated with bi le stasis. Am J Surg 1981; 141: 51–6.
- Messing B, Bories C, Kunstlinger F, Bernier JJ. Does total par-enteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology 1983; 84: 1012–9.
- Mendez-Sanchez N, King-Martinez AC, Ramos MH, et al. The Amerindian's genes in the Mexican population are associated with development of gallstone disease. Am J Gastroenterol 2004; 99: 2166–70.
- Katsika D, Grjibovski A, Einarsson C, et al. Genetic and environmental infl uences on symptomatic gallstone disease: A Swedish study of 43,141 twin pairs. Hepatology 2005; 41: 1138–43.
- Sarin SK, Negi VS, Dewan R, et al. High familial prevalence of gallstones in the first-degree relatives of gallstone patients. Hepatology 1995; 22: 138–41.
- Maclure KM, Hayes KC, Colditz GA, et al. Weight, diet, and the risk of symptomatic gallstones in middle-aged women. N Engl J Med 1989; 321: 563–9.
- Erlinger S. Gallstones in obesity and weight loss. Eur J Gastro-enterol Hepatol 2000; 12: 1347–52.
- Sugerman H J, Brewer W H, Shiffman M L, et al. A multicenter, placebo-controlled, randomized, double-blind, prospective trial of prophylactic ursod iol for the prevention of ga llstone formation following gastric-bypass-induced rapid weight loss. Am J Surg 1995; 169: 91–6; discussion 96–7.
- Rosmorduc O, Hermelin B, Poupon R. MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis. Gastroenterology 2001; 120: 1459–67.
- Rosmorduc O, Hermelin B, Boelle PY, et al. ABCB4 gene mutation-associated cholelithiasis in adults. Gastroenterology 2003; 125: 452–9.
- Coelho JC, Bonilha R, Pitaki SA, et al. Prevalence of gallstones in a Brazilian population. Int Surg 1999; 84: 25–8.
- Ko CW, Beresford SA, Schulte SJ, et al. Incidence, natural history, and risk factors for biliary sludge and stones during pregnancy. Hepatology 2005; 41: 359–65.
- Tyler CV Jr, Zyzanski S J, Runser L. Increased risk of symptomat-ic gallbladder disease in adults with Down sy ndrome. Am J Med Genet A 2004; 130: 351–3.
- Strom BL, Tamragouri R N, Morse M L, et al. Oral contraceptives and other risk factors for gallbladder disease. Clin Pharmacol Ther 1986; 39: 335–41.
- Leitzmann MF, Willett WC, Rimm EB, et al. A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JA M A 1999; 281: 2106–12.
- Ransohoff DF, Gracie WA. Treatment of gallstones. Ann Intern Med 1993; 119: 606–19.
- Angelico F, Del Ben M, Barbato A, et al. Ten-year incidence and natural history of gallstone disease in a rural population of women in central Italy. The Rome Group for the Epidemiology and Prevention of Cholelithiasis (GREPCO). Ital J Gastroent-erol Hepatol 1997; 29: 249–54.
- Wenckert A, Robertson B. The natural course of gallstone disease: eleven-year review of 781 nonoperated cases. Gastroen-terology 1966; 50: 376–81.
- Friedman GD. Natural history of asymptomatic and symptomatic gallstones. Am J Surg 1993; 165: 399–404.
- Gracie WA, Ransohoff DF. The natural history of silent gallstones: the innocent gallstone is not a myth. N Engl J Med 1982; 307: 798–800.
- Cucchiaro G, Watters CR, Rossitch JC, Meyers WC. Deaths f rom gallstones. Incidence and associated clinical factors. Ann Surg 1989; 209: 149–51.
- Landau O, Deutsch AA, Kott I, et al. The r isk of cholecystec tomy for acute cholecystitis in diabetic patients. Hepatogastroen-terology 1992; 39: 437–8.
- Del Favero G, Caroli A, Meggiato T, et al. Natural history of gallstones in non-insulin-dependent diabetes mellitus. A prospective 5-year follow-up. Dig Dis Sci 1994; 39: 1704–7.
- Friedman LS, Roberts MS, Brett AS, Marton KI. Management of asymptomatic gallstones in the diabetic patient. A decision analysis. Ann I ntern Med 1988; 109: 913–9.
- Corazziari E, Shaffer EA, Hogan WJ, et al. Functional disorders of the biliary tract and pancreas. Gut 1999; 45 (Suppl. 2): II48–54.
- Bates T, Ebbs SR, Harrison M, A' Hern RP. Infl uence of cholecys-tectomy on symptoms. Br J Surg 1991; 78: 964–7.
- Diehl AK. Symptoms of gallstone disease. Baillieres Clin Gastroenterol 1992; 6: 635–57.
- Thistle JL, Cleary PA, Lachin JM, et al. The natural history of cholelithiasis: the National Cooperative Gallstone Study. Ann Intern Med 1984; 101: 171–5.
- May GR, Sutherland LR, Shaffer EA. Efficacy of bile acid therapy for gallstone dissolution: a meta-analysis of randomized trials. Aliment Pharmacol Ther 1993; 7: 139–48.
- Sauerbruch T, Paumgartner G. Gallbladder stones: management. Lancet 1991; 338: 1121–4.
- Hellstern A, Leuschner U, Benjaminov A, et al. Dissolution of gallbladder stones with methyl tert-butyl ether and stone recurrence: a European survey. Dig Dis Sci 1998; 43: 911–20.
- Ponchon T, Baroud J, Pujol B, et al. Renal fa ilure dur ing d issolu-tion of gallstones by methyl-tert-butyl ether. Lancet 1988; 2: 276–7.
