Chapter 1.8
Hepatic Stem Cells
Tania Roskams,
Tania Roskams
Search for more papers by this authorTania Roskams,
Tania Roskams
Search for more papers by this authorBook Editor(s):Juan Rodés MD,
Jean-Pierre Benhamou MD,
Andres T. Blei MD,
Jürg Reichen MD,
Mario Rizzetto MD,
Juan Rodés MD
Director General, Hospital Clinic; Professor of Medicine, University of Barcelona, Barcelona, Spain
Search for more papers by this authorJean-Pierre Benhamou MD
Professor of Hepatology, Université Denis Diderot Paris 7, Assistance Publique — Hôpitaux de Paris and Inserm U773, Service d'Hépatologie, Hôpital Beaujon, Clichy, France
Search for more papers by this authorAndres T. Blei MD
Professor of Medicine and Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Search for more papers by this authorJürg Reichen MD
Professor of Medicine, University of Bern; Chief of Hepatology, University Hospital, Bern, Switzerland
Search for more papers by this authorMario Rizzetto MD
Professor of Gastroenterology, University of Turin, Turin, Italy
Search for more papers by this authorFirst published: 18 June 2007
Summary
This chapter contains section titled:
-
Introduction
-
Different types of Stem Cells and their Niches
-
Hepatocytes have ‘Stem Cell’ Properties
-
Hepatic Progenitor Cells: Localization and Activation
-
The Society of Liver Cells and the Surrounding Stroma; the Liver Stem Cell Niche
-
The Possible Role of Progenitor Cells in Liver Cancer
-
Conclusions
-
References
References
- Watt FM, Hogan BL (2000) Out of Eden: stem cells and their niches. Science 287, 1427–1430.
- Alison M, Sarraf C (1998) Hepatic stem cells. J Hepatol 29, 676–682.
- Hall PA (1989) What are stem cells and how are they controlled? J Pathol 158, 275–277.
- D Orlic, TA Bock, L Kanz (eds) (1999) Hematopoietic Stem Cells. Biology and Transplantation. New York: New York Academy of Science.
- Rubinstein P, Carrier C, Caradavou A et al. (1998) Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 339, 1565–1577.
- DMR Levitt (ed.) (1995) Hematopoietic Stem Cells. New York: Marcel Dekker.
- He XC, Zhang J, Li L (2005) Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior. Ann NY Acad Sci 1049, 28–38.
- Zhang J, Niu C, Ye L et al. (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836–841.
- Michalopoulos GK, DeFrances MC (1997) Liver regeneration. Science 276, 60–66.
- Fausto N (2004) Liver regeneration and repair: hepatocytes, progenitor cells, and stem cells. Hepatology 39, 1477–1487.
- Overturf K, Al-Dhalimy M, Finegold M et al. (1999) The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion. Am J Pathol 155, 2135–2143.
- Overturf K, Al-Dhalimy M, Manning K et al. (1998) Ex vivo hepatic gene therapy of a mouse model of hereditary tyrosinemia type I. Hum Gene Ther 9, 295–304.
- Roskams T, Libbrecht L, Desmet V (2003) Progenitor cells in diseased human liver. Semin Liver Dis 23, 385–396.
- Roskams TA, Thiese ND, Balabaud C et al. (2004) Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 39, 1739–1745.
- Wilson JW, Leduc EH (1958) Role of cholangioles in restoration of the liver of the mouse after dietary injury. J Pathol Bacteriol 76, 441–449.
- Alison MR, Golding M, Scarraf CE et al. (1996) Liver damage in the rat induces hepatocyte stem cells from biliary epithelial cells. Gastroenterology 110, 1182–1190.
- Roskams T, Yang SQ, Koteish A et al. (2003) Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease. Am J Pathol 163, 1301–1311.
- Yang S, Koteish A, Lin H et al. (2004) Oval cells compensate for damage and replicative senescence of mature hepatocytes in mice with fatty liver disease. Hepatology 39, 403–411.
- Roskams T, Desmet V (1998) Ductular reaction and its diagnostic significance. Semin Diagn Pathol 15, 259–269.
- Lowes KN, Brennan BA, Yeoh GC et al. (1999) Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 154, 537–541.
- Libbrecht L et al. (2000) Deep intralobular extension of human hepatic ‘progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis: can ‘progenitor cells’ migrate? J Pathol 192, 373–378.
- Falkowski O, Desmet V, Roskams T et al. (2003) Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells. J Hepatol 39, 357–364.
- Wiemann SU, Desmet V, Roskams T et al. (2002) Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. FASEB J 16, 935–942.
- Marshall A et al. (2005) Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology 128, 33–42.
- Roskams T (2003) Progenitor cell involvement in cirrhotic human liver diseases: from controversy to consensus. J Hepatol 39, 431–434.
- Thorgeirsson SS, Grisham JW (2006) Hematopoietic cells as hepatocyte stem cells: a critical review of the evidence. Hepatology 43, 2–8.
- Jakubowski A, Ambrose C, Parr M et al. (2005) TWEAK induces liver progenitor cell proliferation. J Clin Invest 115, 2330–2340.
- Cassiman D, Libbrecht L, Desmet V et al. (2002) Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers. J Hepatol 36, 200–209.
- Ros JE, Roskams T, Geuken M et al. (2003) High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol 200, 553–560.
- Ros JE, Libbrecht L, Geuken M et al. (2003) ATP binding cassette transporter gene expression in rat liver progenitor cells. Gut 52, 1060–1067.
- Sell S (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51, 1–28.
- Hixson DC, Brown J, McBride AC et al. (2000) Differentiation status of rat ductal cells and ethionine-induced hepatic carcinomas defined with surface-reactive monoclonal antibodies. Exp Mol Pathol 68, 152–169.
- Dumble ML, Croager EJ, Yeoh GC et al. (2002) Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 23, 435–445.
- Libbrecht L, Desmet V, Roskams T (2005) Preneoplastic changes in human hepatocarcinogenesis. Liver Int 25, 1–12.
- Yoon DS, Jeong J, Park YN et al. (1999) Expression of biliary antigen and its clinical significance in hepatocellular carcinoma. Yonsei Med J 40, 472–477.
- Van Eyken P et al. (1988) Cytokeratin expression in hepatocellular carcinoma: an immunohistochemical study. Hum Pathol 12, 562–568.
- Hsia CC, Evarts RP, Natatsukasa H et al. (1992) Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 16, 1327–1633.
- Durnez A (2006) The clinicopathological and prognostic relevance of cytokeratin 7 and 19 expression in hepatocellular carcinoma. A possible progenitor cell organ. Histopathology 49, 138–151.
- Wu PC, Lai VC, Fang JW et al. (1999) Hepatocellular carcinoma expressing both hepatocellular and biliary markers also expresses cytokeratin 14, a marker of bipotential progenitor cells. J Hepatol 31, 965–966.
- Uenishi T, Kubo S, Yamamoto T et al. (2003) Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence. Cancer Sci 94, 851–857.
- Ding SJ, Li Y, Tan YX et al. (2004) From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol Cell Proteomics 3, 73–81.
- Libbrecht L, Desmet V, Van Damme B et al. (2000) The immunohistochemical phenotype of dysplastic foci in human liver: correlation with putative progenitor cells. J Hepatol 33, 76–84.
- Fiegel HC, Gluer S, Roth B et al. (2004) Stem-like cells in human hepatoblastoma. J Histochem Cytochem 52, 1495–1501.
- Xiao JC, Ruck P, Adam A et al. (2003) Small epithelial cells in human liver cirrhosis exhibit features of hepatic stem-like cells: immunohistochemical, electron microscopic and immunoelectron microscopic findings. Histopathology 42, 141–149.
- Ruck P, Xiao J-C, Kaiserling E (1996) Small epithelial cells and the histogenesis of hepatoblastoma. Electron microscopic, immunoelectron microscopic, and immunohistochemical findings. Am J Pathol 148, 321–329.
- Nomoto K, Tsuneyama K, Abdel Aziz HO et al. (2006) Intrahepatic cholangiocarcinoma arising in cirrhotic liver frequently expressed p63-positive basal/stem-cell phenotype. Pathol Res Pract 202, 71–76.
- Alison MR, Lovell MJ (2005) Liver cancer: the role of stem cells. Cell Prolif 38, 407–421.
