Chapter 19.2
Extrahepatic Biliary Obstruction: Systemic Effects, Diagnosis and Management
Michelle C. Gallagher,
James S. Dooley,
Michelle C. Gallagher
Search for more papers by this authorJames S. Dooley
Search for more papers by this authorMichelle C. Gallagher,
James S. Dooley,
Michelle C. Gallagher
Search for more papers by this authorJames S. Dooley
Search for more papers by this authorBook Editor(s):Juan Rodés MD,
Jean-Pierre Benhamou MD,
Andres T. Blei MD,
Jürg Reichen MD,
Mario Rizzetto MD,
Juan Rodés MD
Director General, Hospital Clinic; Professor of Medicine, University of Barcelona, Barcelona, Spain
Search for more papers by this authorJean-Pierre Benhamou MD
Professor of Hepatology, Université Denis Diderot Paris 7, Assistance Publique — Hôpitaux de Paris and Inserm U773, Service d'Hépatologie, Hôpital Beaujon, Clichy, France
Search for more papers by this authorAndres T. Blei MD
Professor of Medicine and Surgery, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Search for more papers by this authorJürg Reichen MD
Professor of Medicine, University of Bern; Chief of Hepatology, University Hospital, Bern, Switzerland
Search for more papers by this authorMario Rizzetto MD
Professor of Gastroenterology, University of Turin, Turin, Italy
Search for more papers by this authorFirst published: 18 June 2007

References
- Bloom D, Daniel PM, Pratt OE et al. (1978) Lymphatic drainage from the liver in biliary obstruction. J Physiol 281, 8P.
- Raper SE, Barker ME, Jones AL et al. (1989) Anatomic correlates of bacterial cholangiovenous reflux. Surgery 105, 352–359.
- Huang T, Bass JA, Williams RD (1969) The significance of biliary pressure in cholangitis. Arch Surg 98, 629–632.
- Tu W, Kitade H, Satoi S et al. (2002) Increased nitric oxide production in hepatocytes is involved in liver dysfunction following obstructive jaundice. J Surg Res 106, 31–36.
- Muriel P, Suarez OR, Gonzalez P et al. (1994) Protective effect of S-adenosyl-L-methionine on liver damage induced by biliary obstruction in rats: a histological, ultrastructural and biochemical approach. J Hepatol 21, 95–102.
- Krahenbuhl S, Talos C, Lauterburg BH et al. (1995) Reduced antiox-idative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22, 607–612.
- Krahenbuhl S, Talos C, Reichen J (1994) Mechanisms of impaired hepatic fatty acid metabolism in rats with long-term bile duct ligation. Hepatology 19, 1272–1281.
- Stieger B, Meier PJ, Landmann L (1994) Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchymal cells. Hepatology 20, 201–212.
- Guicciardi ME, Gores GJ (2005) Cholestatic hepatocellular injury: what do we know and how should we proceed. J Hepatol 42, 297–300.
- Sokol RJ, Dahl R, Devereaux MW et al. (2005) Human hepatic mitochondria generate reactive oxygen species and undergo the permeability transition in response to hydrophobic bile acids. J Pediatr Gastroenterol Nutr 41, 235–243.
- Vitale GC, Siow Y, Baker PR et al. (1992) Reversible bile acid changes in bile duct obstruction and its potential for hepatocellular injury. J Hepatol 14, 151–156.
- Schoemaker MH, Gommans WM, Conde de la Rosa, L et al. (2003) Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol 39, 153–161.
- Rolo AP, Palmeira CM, Holy JM et al. (2004) Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis. Toxicol Sci 79, 196–204.
- Sokol RJ, Twedt D, McKim JM, Jr et al. (1994) Oxidant injury to hepatic mitochondria in patient's with Wilson's disease and Bedlington terriers with copper toxicosis. Gastroenterology 107, 1788–1798.
- Gu M, Cooper JM, Butler P et al. (2000) Oxidative-phosphorylation defects in liver of patients with Wilson's disease. Lancet 356, 469–474.
- Koyama K, Takagi Y, Ito K et al. (1981) Experimental and clinical studies on the effect of biliary drainage in obstructive jaundice. Am J Surg 142, 293–299.
- McPherson GA, Benjamin IS, Boobis AR et al. (1982) Antipyrine elimination as a dynamic test of hepatic functional integrity in obstructive jaundice. Gut 23, 734–738.
- Tsubono T, Tsukada K, Hatakeyama K (1995) Hepatic functional reserve in patients with obstructive jaundice: an assessment by the redox tolerance test. Am J Surg 169, 300–303.
- Dooley JS, Bartholomew C, Summerfield JA et al. (1984) The biliary excretion of sulphated and non-sulphated bile acids and bilirubin in patients with external bile drainage. Clin Sci 67, 61–68.
- Little JM, Robotin M (1986) Serum bilirubin after surgery for obstructive jaundice. Aust NZ J Surg 56, 35–37.
- Krahenbuhl S, Marti U, Grant I et al. (1995) Characterization of mechanisms causing hypoalbuminemia in rats with long-term bile duct ligation. J Hepatol 23, 79–86.
- Ostrow JD, Pascolo L, Shapiro SM et al. (2003) New concepts in bilirubin encephalopathy. Eur J Clin Invest 33, 988–997.
- Gollan JL, Billing BH, Huang SN (1976) Ultrastructural changes in the isolated rat kidney induced by conjugated bilirubin and bile acids. Br J Exp Pathol 57, 571–581.
- Ferreira M, Coxito PM, Sardao VA et al. (2005) Bile acids are toxic for isolated cardiac mitochondria: a possible cause for hepatic-derived cardiomyopathies' Cardiovasc Toxicol 5, 63–73.
- Binah O, Rubinstein I, Bomzon A et al. (1987) Effects of bile acids on ventricular muscle contraction and electrophysiological properties: studies in rat papillary muscle and isolated ventricular myocytes. Arch Pharmacol 335, 160–165.
- Harry DS, McIntyre N (1992) Plasma lipoproteins and the liver. In: GH Millward-Sadler R Wright MJP Arthur (eds) Liver and Biliary Disease, 3rd edn. London: W.B. Saunders, pp. 61–78.
- Owen JS, Bruckdorfer KR, Day RC et al. (1982) Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease. J Lipid Res 23, 124–132.
- Owen JS (1990) Extrahepatic cell lipid abnormalities and cellular dysfunction in liver disease. Drugs 40 (Suppl. 3), 73–83.
- Jackson PA, Morgan DB (1982) The relation between membrane cholesterol and phospholipids and sodium efflux in erythrocytes from healthy subjects and patients with chronic cholestasis. Clin Sci 62, 101–107.
- North P, Fleischer S (1983) Alteration of synaptic membrane cholesterol/phospholipid ratio using a lipid transfer protein. Effect on gamma-aminobutyric acid uptake. J Biol Chem 258, 1242–1253.
- Hyogo H, Tazuma S, Nishioka T et al. (2001) Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model. Dig Dis Sci 46, 2089–2097.
- Swain MG, Maric M (1995) Defective corticotrophin-releasing hormone mediated neuroendocrine and behavioural responses in cholestatic rats: implications for cholestatic liver disease-related sickness behaviors. Hepatology 22, 1560–1564.
- Burak KW, Le T, Swain MG (2002) Increased sensitivity to the locomotor-activating effects of corticotrophin-releasing hormone in cholestatic rats. Gastroenterology 122, 681–688.
- Swain MG, Le T (1998) Chronic cholestasis in rats induces anhedonia and a loss of social interest. Hepatology 28, 6–10.
- Forton DM, Patel N, Prince M et al. (2004) Fatigue and primary biliary cirrhosis: association of globus pallidus magnetisation transfer ratio measurements with fatigue severity and blood manganese levels. Gut 53, 475–477.
- Silverberg DS, Iaina A, Reisin E et al. (1977) Cholestyramine in uraemic pruritus. Br Med J 1, 752–753.
- Bartholomew TC, Summerfield JA, Billing BH et al. (1982) Bile acid profiles of human serum and skin interstitial fluid and their relationship to the pruritus studied by gas chromatography-mass spectrometry. Clin Sci 63, 65–73.
- O'Keeffe C, Baird AW, Nolan N et al. (2004) Cholestatic pruritus -the role of cutaneous mast cells and nerves. Aliment Pharmacol Ther 19, 1293–1300.
- Bergasa NV (2005) The pruritus of cholestasis. J Hepatol 43, 1078–1088.
- Bergasa NV, Alling DW, Talbot TL et al. (1995) Effect of naloxone infusions in patients with the pruritus of cholestasis. A double-blind, randomized, controlled trial. Ann Intern Med 123, 161–167.
- Bergasa NV, Link MJ, Keogh M et al. (2001) Pilot study of bright-light therapy reflected towards the eyes for the pruritus of chronic liver disease. Am J Gastroenterol 96, 1563–1570.
- O'Donoghue JW, Pereira SP, Ashdown AC et al. (2005) A controlled trial of ondansetron in the pruritus of cholestasis. Aliment Pharmacol Ther 21, 1041–1045.
- Green J, Better OS (1995) Systemic hypotension and renal failure in obstructive jaundice — mechanistic and therapeutic aspects. J Am Soc Nephrol 5, 853–871.
-
Sharsha SM,
Better OS,
Chaimovitz C et al.
(1976)
Haemodynamic studies in dogs with bile duct ligations.
Clin Sci
50,
533–537.
10.1042/cs0500533 Google Scholar
- Williams RD, Elliott DW, Zollinger RM (1960) The effect of hypotension in obstructive jaundice. Arch Surg 81, 334–340.
- Bomzon L, Wilton PB, McCalden TA (1978) Impaired skeletal muscle vasomotor response to infused noradrenaline in baboons with obstructive jaundice. Clin Sci 55, 109–112.
- Jacob G, Said O, Finberg J et al. (1993) Peripheral vascular neuroeffector mechanisms in experimental cholestasis. Am J Physiol 265, G579–586.
- Ebrahimi F, Tavakoli S, Hajrasouliha AR et al. (2005) Contribution of endogenous opioids and nitric oxide to papillary muscle contractile impairment in cholestatic rats. Eur J Pharmacol 523, 93–100.
- Borhani AA, Houshmand G, Samini M et al. (2005) Alpha2-adreno-ceptor subsensitivity in mesenteric vascular bed of cholestatic rats: the role of nitric oxide and endogenous opioids. Eur J Pharmacol 514, 183–189.
- Tajuddin M, Tariq M, Bilgrami NL et al. (1980) Biochemical and pathological changes in the heart following bile duct ligation. Adv Myocardiol 2, 209–212.
- Binah O, Bomzon A, Blendis LM et al. (1985) Obstructive jaundice blunts myocardial contractile response to isoprenaline in the dog: a clue to the susceptibility of jaundice patients to shock? Clin Sci 69, 647–653.
- Green J, Beyar R, Sideman S et al. (1986) The ‘jaundiced heart’, a possible explanation for post-operative shock in obstructive jaundice. Surgery 100, 14–20.
- Fogarty BJ, Parks RW, Rowlands BJ et al. (1995) Renal dysfunction in obstructive jaundice. Br J Surg 82, 877–884.
- Holt S, Marley R, Fernando B et al. (1999) Acute cholestasis-induced renal failure: effects of antioxidants and ligands for the thromboxane A2 receptor. Kidney Int 55, 271–277.
- Kramer HJ, Schwarting K, Backer A et al. (1997) Renal endothelin system in obstructive jaundice: its role in impaired renal function of bile-duct ligated rats. Clin Sci (Lond) 92, 579–585.
- Utkan ZN, Utkan T, Sarioglu Y et al. (2000) Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: role of endothelium and duration of bile duct ligation. Clin Exp Pharmacol Physiol 27, 339–344.
- Claria J, Jimenez W, Ros J et al. (1992) Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide. Hepatology 15, 343–349.
- Zambraski EJ, Dunn MJ (1984) Importance of renal prostaglandins in control of renal function after chronic ligation of the common bile duct in dogs. J Lab Clin Med 103, 549–559.
- Kramer HJ, Schwarting K, Backer A (1995) Impaired renal function in obstructive jaundice: enhanced glomerular thromboxane synthesis and effects of thromboxane receptor blockade in bile duct-ligated rats. Clin Sci (Lond) 88, 39–45.
- Baum M, Stirling GA, Dawson JL (1969) Further study into obstructive jaundice and ischaemic renal damage. Br Med J (Clin Res) 2, 229–231.
- Aoyagi T, Lowenstein LM (1968) The effect of bile salts and renal ischaemic on renal function. J Lab Clin Med 71, 686–692.
- Allison MEM, Moss NG, Fraser MM et al. (1978) Renal function in chronic obstructive jaundice: a micropuncture study in rats. Clin Sci 54, 649–659.
- Bloom D, McCalden TA, Rosendorff C (1975) The effects of hyperc-holesterolaemic plasma on vascular sensitivity to noradrenaline. Br J Pharmacol 54, 421–427.
- Dooley JS, Hamilton-Miller JMT, Boss, M et al. (1983) Tubular cell damage and impaired renal clearance of mezlocillin in patients with obstructive jaundice. Hepatology 3, 853A.
- Better OS, Guckian V, Giebisch G et al. (1987) The effect of sodium taurocholate on proximal tubular reabsorption in the rat kidney. Clin Sci (Lond) 72, 139–141.
- Alon U, Berant M, Mordechovitz D et al. (1982) The effect of intrarenal infusion of bile on kidney function in the dog. Clin Sci (Lond) 62, 431–433.
- Finestone H, Fechner C, Levy M (1984) Effects of bile and bile salt infusions on renal function in dogs. Can J Physiol Pharmacol 62, 762–768.
- Alon U, Daviddai G, Harpaz S et al. (1988) Role of renal prostaglandins in bile-induced diuresis in the dog. Miner Electrolyte Metab 14, 338–342.
- Sellinger M, Haag K, Burckhardt G et al. (1990) Sulfated bile acids inhibit Na(+)-H+ antiport in human kidney brush-border membrane vesicles. Am J Physiol 258, F986–991.
- Martinez-Rodenas F Oms LM Carulla X et al. (1989) Measurement of body water compartments after ligation of the common bile duct in the rabbit. Br J Surg 76, 461–464.
- Sitprija V, Kashemsant U, Sriratanaban A et al. (1990) Renal function in obstructive jaundice in man: cholangiocarcinoma model. Kidney Int 38, 948–955.
- Lucena MI, Andrade RJ, Cabello MR et al. (1995) Aminoglycoside-associated nephrotoxicity in extrahepatic obstructive jaundice. J Hepatol 22, 189–196.
- Thompson JE, Pitt HA, Doty JE et al. (1990) Broad spectrum penicillin as an adequate therapy for acute cholangitis. SGO 171, 275–282.
- Vakil N Abu-Alfa A Mujais SK (1989) Gentamicin nephrotoxicity in extrahepatic cholestasis: modulation by dietary calcium. Hepatology 9, 518–524.
- Thompson JN, Cohen J, Moore RH et al. (1988) Endotoxemia in obstructive jaundice. Observations on cause and clinical significance. Am J Surg 155, 314–321.
- Ingoldby CJ, McPherson GA, Blumgart LH (1984) Endotoxemia in human obstructive jaundice. Effect of polymyxin B. Am J Surg 147, 766–771.
- Clements WD, Parks R, Erwin P et al. (1996) Role of the gut in the pathophysiology of extrahepatic biliary obstruction. Gut 39, 587–593.
- Kocsar LT, Bertok L, Varteresz V (1969) Effect of bile acids on the intestinal absorption of endotoxin in rats. J Bacteriol 100, 220–223.
- Van Bossuyt H, Desmaretz C, Gaeta GB et al. (1990) The role of bile acids in the development of endotoxaemia during obstructive jaundice in the rat. J Hepatol 10, 274–279.
- Cahill CJ (1983) Prevention of postoperative renal failure in patients with obstructive jaundice — the role of bile salts. Br J Surg 70, 590–595.
- Lumsden AB, Henderson JM, Alspaugh J (1989) Endotoxemia during percutaneous manipulation of the obstructed biliary tree. Am J Surg 158, 21–24.
- Clements WD, Halliday MI, McCaigue MD et al. (1993) Effects of extrahepatic obstructive jaundice on Kupffer cell clearance capacity. Arch Surg 128, 200–204.
- Lumsden AB, Henderson JM, Kutner MH (1988) Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis. Hepatology 8, 232–235.
- Roelofsen H, van der Veere CN, Ottenhoff R et al. (1994) Decreased bilirubin transport in the perfused liver of endotoxemic rats. Gastroenterology 107, 1075–1084.
- Ingoldby CJ, McPherson GA, Blumgart LH (1984) Endotoxaemia in human obstructive jaundice. Effect of polymyxin B. Am J Surg 147, 766–771.
- Cavanagh D, Rao PS, Sutton DM et al. (1970) Pathophysiology of endotoxin shock in the primate. Am J Obstet Gynecol 108, 705–722.
- Kikeri D, Pennell JP, Hwang KH et al. (1986) Endotoxemic acute renal failure in awake rats. Am J Physiol 250, F1098–1106.
- Colucci M, Paramo JA, Collen D (1985) Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation. J Clin Invest 75, 818–824.
- Inan M, Sayek I, Tel BC et al. (1997) Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice. Br J Surg 84, 943–947.
- Jolobe OMP (1998) Role of endotoxin and nitric oxide in the pathogenesis of renal failure in obstructive jaundice. Br J Surg 85, 1747.
- Dixon JM, Armstrong CP, Duffy SW et al. (1984) Upper gastrointestinal bleeding. A significant complication after surgery for relief of obstructive jaundice. Ann Surg 199, 271–275.
- Urakawa T, Nagahata Y, Nakamoto M et al. (1987) An approach to the mechanism of acute ulceration in obstructive jaundice. Scand J Gastroenterol 22, 634–640.
- Yoshida M, Koga A (1988) Alterations with time of secretion and ultrastructure of the exocrine pancreas in rats with an obstructed biliary system. Br J Exp Pathol 69, 441–448.
- Gouma DJ, Roughneen PT, Kumar S et al. (1986) Changes in nutritional status associated with obstructive jaundice and biliary drainage in rats. Am J Clin Nutr 44, 362–369.
- Padillo FJ, Andicoberry B, Naranjo A et al. (2001) Anorexia and the effect of internal biliary drainage on food intake in patients with obstructive jaundice. J Am Coll Surg 192, 584–590.
- Freund H, James JH, Brenner W et al. (1980) Plasma amino acid analysis in the differential diagnosis of jaundice. Am J Surg 139, 142–148.
- Starnes HF, Jr Conti PS Warren RS et al. (1987) Altered peripheral amino acid uptake in obstructive jaundice. J Surg Res 42, 383–393.
- Armstrong CP, Dixon JM, Duffy SW et al. (1984) Wound healing in obstructive jaundice. Br J Surg 71, 267–270.
- Arnaud J-P, Humbert W, Eloy M-R et al. (1981) Effect of obstructive jaundice on wound healing. An experimental study in rats. Am J Surg 141, 593–596.
- Greaney MG, Van Noort R, Smythe A et al. (1979) Does obstructive jaundice adversely affect wound healing? Br J Surg 66, 478–481.
- Bayer I, Ellis H (1976) Jaundice and wound healing: an experimental study. Br J Surg 63, 392–396.
- Than T (1976) Skin prolyl hydroxylase and tensiometry in jaundice. PhD Thesis, University of Glasgow.
- Ellis H, Heddle R (1977) Does the peritoneum need to be closed at laparotomy? Br J Surg 64, 733–736.
- Clifton PM, Barter PJ, Malkinon AM (1982) High density lipoprotein particle size distribution in subjects with obstructive jaundice. J Lipid Res 23, 121–125.
- Owen JS, Brown DJC, Harry DS et al. (1985) Erythrocyte echinocy-tosis in liver disease. Role of abnormal plasma high density lipoproteins. J Clin Invest 76, 2275–2285.
- Heron DS, Shinitzky M, Hershkowitz M et al. (1980) Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes. Proc Natl Acad Sci USA 77, 7463–7467.
- Kimmings N, Sewnath ME, Mairuhu WM et al. (2001) The abnormal lipid spectrum in malignant obstructive jaundice in relation to endotoxin sensitivity and the result of preoperative biliary drainage. Surgery 129, 282–291.
- Hay JE (1998) Osteoporosis. Clin Liver Dis 2, 407–419.
- Guanabens N, Pares A, Ros I et al. (2005) Severity of cholestasis and advanced histological stage but not menopausal status are the major risk factors for osteoporosis in primary biliary cirrhosis. J Hepatol 42, 573–577.
- Hay JE, Lindor KD, Wiesner RH et al. (1991) The metabolic bone disease of primary sclerosing cholangitis. Hepatology 14, 257–261.
- Janes CH, Dickson ER, Okazaki R et al. (1995) Role of hyperbilirubi-naemia in the impairment of osteoblast proliferation associated with cholestatic jaundice. J Clin Invest 95, 2581–2586.
- Kimmings AN, van Deventer SJH, Obertop H et al. (1995) Inflammatory and immunological effects of obstructive jaundice: pathogenesis and treatment. J Am Coll Surg 181, 567–581.
- Pain JA (1987) Reticuloendothelial function in obstructive jaundice. Br J Surg 74, 1091–1094.
- Scriven MW, Horrobin DF, Puntis MC (1994) Study of plasma and red cell phospholipids fatty acids in extrahepatic cholestatic jaundice. Gut 35, 987–990.
- Ding JW, Andersson R, Stenram U et al. (1992) Effect of biliary decompression on reticuloendothelial function in jaundiced rats. Br J Surg 79, 648–652.
- Scott-Conner CE Grogan JB Scher KS et al. (1989) Impaired clearance of Escherichia coli bacteremia in early biliary obstruction. Am J Surg 157, 210–214.
- Collier DS, Pain JA, Wight DG et al. (1986) The Kupffer cell in experimental extrahepatic cholestasis in the rat — a light microscopy, immunohistochemical and electron microscopy study. J Pathol 150, 187–194.
- Roughneen PT, Drath DB, Kulkarni AD et al. (1987) Impaired nonspecific cellular immunity in experimental cholestasis. Ann Surg 206, 578–582.
- Greve JW, Gouma DJ, Soeters PB et al. (1990) Suppression of cellular immunity in obstructive jaundice is caused by endotoxins: a study with germ-free rats. Gastroenterology 98, 478–485.
- Swain MG, Tjandra K, Kanwar S et al. (1995) Neutrophil adhesion is impaired in rat model of cholestasis. Gastroenterology 109, 923–932.
- Levy R, Schlaeffer F, Keynan A et al. (1993) Increased neutrophil function induced by bile duct ligation in a rat model. Hepatology 17, 908–914.
- Clements WD, McCaigue M, Erwin P et al. (1996) Biliary decompression promotes Kupffer cell recovery in obstructive jaundice. Gut 38, 925–931.
- Roughneen PT, Gouma DJ, Kulkarni AD et al. (1986) Impaired specific cell-mediated immunity in experimental biliary obstruction and its reversibility by internal biliary drainage. J Surg Res 41, 113–125.
- Feduccia TD Scott-Conner CE Grogan JB (1988) Profound suppression of lymphocyte function in early biliary obstruction. Am J Med Sci 296, 39–44.
- Beaudoin JG, Rabbat AG (1969) Effect of biliary obstruction on skin allograft survival in mice. Transplantation 7, 576–577.
- Roughneen PT, Kulkarni AD, Gouma DJ et al. (1986) Suppression of host-versus-graft response in experimental biliary obstruction. Transplantation 42, 687–689.
- Thompson RL, Ranjbar S, Rowlands BJ (1993) T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. World J Surg 17, 783–785.
- Fan ST, Lo CM, Lai EC et al. (1994) T lymphocyte function in patients with malignant biliary obstruction. J Gastroenterol Hepatol 9, 391–395.
- Thong YH, Ferrante A, Ness D (1977) Neutrophil phagocytic and bactericidal dysfunction induced by bilirubin. Aust Paediatr J 13, 287–289.
- Thong YH, Ferrante A (1977) Adverse effect of bilirubin on the chemotactic responsiveness of human neutrophils. IRCS J Med Sci 5, 483.
- Rola-Pleszcynski M Hensen SA Vincent MM et al. (1975) Inhibitory effects of bilirubin on cellular responses in man. J Pediatr 86, 690–696.
- Cainzos M, Patel J, Puente JL (1988) Anergy in jaundiced patients. Br J Surg 75, 147–149.
- Bemelmans MH, Gouma DJ, Greve JW et al. (1992) Cytokines tumour necrosis factor and interleukin-6 in experimental biliary obstruction in mice. Hepatology 15, 1132–1136.
- Padrillo FJ, Muntane J, Muntero JL et al. (2002) Effect of internal biliary drainage on plasma levels with obstructive jaundice. World J Surg 26, 1328–1332.
- Bemelmans MH, Greve JW, Gouma DJ et al. (1996) Increased concentrations of tumour necrosis factor (TNF) and soluble TNF receptors in biliary obstruction in mice: soluble TNF receptors as prognostic factors for mortality. Gut 38, 447–453.
- Whiting JF, Green RM, Rosenbluth AB et al. (1995) Tumour necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis. Hepatology 22, 1273–1278.
- Deitch EA, Sittig K, Li M et al. (1990) Obstructive jaundice promotes bacterial translocation from the gut. Am J Surg 159, 79–84.
- Ding JW, Andersson R, Soltesz V et al. (1994) Obstructive jaundice impairs reticuloendothelial function and promotes bacterial translocation in the rat. J Surg Res 57, 238–245.
- Slocum MM, Sittig KM, Specian RD et al. (1992) Absence of intestinal bile promotes bacterial translocation. Am Surg 58, 305–310.
- Deitch EA, Ma L, Ma WJ et al. (1989) Inhibition of endotoxin-induced bacterial translocation in mice. J Clin Invest 84, 36–42.
- Ding JW, Andersson R, Soltesz VL et al. (1994) Inhibition of bacterial translocation in obstructive jaundice by muramyl tripeptide phos-phatidylethanolamine in the rat. J Hepatol 20, 720–728.
- Kalambaheti T, Cooper GN, Jackson GD (1994) Role of bile in nonspecific defence mechanisms of the gut. Gut 35, 1047–1052.
- Hunt DR, Allison ME, Prentice CR et al. (1982) Endotoxemia, disturbance of coagulation, and obstructive jaundice. Am J Surg 144, 325–329.
- Semeraro N, Montemurro P, Chetta G et al. (1989) Increased pro-coagulant activity of peripheral blood monocytes in human and experimental obstructive jaundice. Gastroenterology 96, 892–898.
- Jedrychowski A, Hillenbrand P, Ajdukiewicz AB et al. (1973) Fibrinolysis in cholestatic jaundice. Br Med J i, 640–642.
- Wardle EN (1974) Fibrinogen in liver disease. Arch Surg 109, 741–746.
- Bowen DJ, Clemmons RM, Meyer DJ et al. (1988) Platelet functional changes secondary to hepatocholestasis and elevation of serum bile acids. Thromb Res 52, 649–654.
- Nissan A, Spira RM, Seror D et al. (1996) Captopril-associated ‘pseudocholangitis’. A case report and review of the literature. Arch Surg 131, 670–671.
- Taylor-Robinson SD Toledano MB Arora S et al. (2001) Increase in mortality rates from intrahepatic cholangiocarcinoma in England and Wales 1968–1998. Gut 48, 816–820.
- Boberg KM, Bergquist A, Mitchell S et al. (2002) Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation. Scand J Gastroenterol 37, 1205–1211.
- Fortson WC, Tedesco FJ, Starnes EC et al. (1985) Marked elevation of serum transaminase activity associated with extrahepatic biliary tract disease. J Clin Gastroenterol 7, 502–505.
- Romagnuolo J, Bardou M, Rahme E et al. (2003) Magnetic resonance cholangiopancreatography: a meta-analysis of test performance in suspected biliary disease. Ann Intern Med 139, 547–557.
- Vaishali MD, Agarwal AK, Upadhyaya DN et al. (2004) Magnetic resonance cholangiopancreatography in obstructive jaundice. J Clin Gastroenterol 38, 887–890.
- Zidi SH, Prat F, Le Guen, O et al. (2000) Performance characteristics of magnetic resonance cholangiography in the staging of malignant hilar stricture. Gut 46, 103–106.
- Gibson RN, Vincent JM, Speer T et al. (2005) Accuracy of computed tomographic intravenous cholangiography (CT-IVC) with iotroxate in the detection of choledocholithiasis. Eur Radiol 15, 1634–1642.
- Shoup M, Hodul P, Aranha GV et al. (2000) Defining a role for endoscopic ultrasound in staging periampullary tumors. Am J Surg 179, 453–456.
- Yusuf TE, Bhutani MS (2004) Role of endoscopic ultrasonography in diseases of the extrahepatic biliary system. J Gastroenterol Hepatol 19, 243–250.
- Rosch T, Hofrichter K, Frimberger E et al. (2004) ERCP or EUS for tissue diagnosis of biliary strictures' A prospective comparative study. Gastrointest Endosc 60, 390–396.
- Lee JH, Salem R, Aslanian H et al. (2004) Endoscopic ultrasound and fine-needle aspiration of unexplained bile duct strictures. Am J Gastroenterol 99, 1069–1073.
- Kurzawinski TR, Selves L, Farouk M et al. (1997) Prospective study of hepatobiliary scintigraphy and endoscopic cholangiography for the detection of early biliary complications after orthotopic liver transplantation. Br J Surg 84, 620–623.
- Tripathi M, Chandrashekar N, Kumar R et al. (2004) Hepatobiliary scintigraphy: an effective tool in the management of bile leak following laparoscopic cholecystectomy. Clin Imaging 28, 40–43.
- Huang P, Do-Xuan-Hop (1937) La ponction transhepatique des canaux bilaires. Bull Soc Med Chir Indochine 62, 1090–1100.
- Okuda K, Tanikawa K, Emura T et al. (1974) Non surgical percutaneous transhepatic cholangiography: diagnostic significance in medical problems of the liver. Am J Dig Dis 19, 21–36.
- Cotton PB (2005) ERCP overview — a 30 year experience. In: P Cotton J Leung (eds) Advanced Digestive Endoscopy: ERCP. Oxford: Blackwell Publishing Ltd, pp. 1–8.
- Speer AG, Cotton PB, Russell RC et al. (1987) Randomised trial of endoscopic versus percutaneous stent insertion in malignant obstructive jaundice. Lancet 2, 57–62.
- Khan SA, Davidson BR, Goldin R et al. (2002) Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut 51 (Suppl. 6), 1–9.
- Padillo FJ, Briceno J, Cruz A et al. (2005) Randomized clinical trial of the effects of intravenous fluid administration on hormonal and renal dysfunction in patients with obstructive jaundice undergoing endoscopic drainage. Br J Surg 92, 39–43.
- Dawson JL (1965) Post-operative renal function in obstructive jaundice: effect of a mannitol diuresis. Br Med J i, 82–86.
- Gubern JM, Sancho JJ, Simo J et al. (1988) A randomized trial on the effect of mannitol on postoperative renal function in patients with obstructive jaundice. Surgery 1–3, 39–44.
- Bailey ME (1976) Endotoxin, bile salts and renal function in obstructive jaundice. Br J Surg 63, 774–778.
- Cahill CJ, Pain JA, Bailey ME (1987) Bile salts, endotoxin and renal function in obstructive jaundice. Surg Gynecol Obstet 165, 519–522.
- Pain JA, Cahill CJ, Gilbert JM et al. (1991) Prevention of postoperative renal dysfunction in patients with obstructive jaundice: a multicentre study of bile salts and lactulose. Br J Surg 78, 467–469.
- Thompson JN, Cohen J, Blenkharn JI et al. (1986) A randomised clinical trial of oral ursodeoxycholic acid in obstructive jaundice. Br J Surg 73, 634–636.
- Pain JA, Bailey ME (1988) Prevention of endotoxaemia in obstructive jaundice — a comparative study of bile salts. Hepato-Biliary Pancreatic Surg 1, 21–27.
- Liehr H, Englisch G, Rasenack U (1980) Lactulose — a drug with antiendotoxin effect. Hepatogastroenterology 27, 356–360.
- Pain JA, Bailey ME (1986) Experimental and clinical study of lactulose in obstructive jaundice. Br J Surg 73, 775–778.
- Parks RW, Diamond T, McCrory DC et al. (1994) Prospective study of postoperative renal function in obstructive jaundice and the effect of perioperative dopamine. Br J Surg 81, 437–439.
- Van den Hazel SJ Speelman P Dankert J et al. (1996) Piperacillin to prevent cholangitis after endoscopic retrograde cholangiopancreatography. Ann Intern Med 125, 442–447.
- Byl B, Deviere J, Strachan MJ et al. (1995) Antibiotics prophylaxis for infectious complications after therapeutic endoscopic retrograde cholangiopancreatography: a randomised, double-blind, placebo-controlled study. Clin Infect Dis 20, 1236–1240.
- Subhani JM, Kibbler C, Dooley JS (1999) Review article: antibiotic prophylaxis for endoscopic retrograde cholangiopancreatography (ERCP). Aliment Pharmacol Ther 13, 103–116.
- ASGE (2003) Guidelines for antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc 58, 475–482.
- Mani V, Cartwright K, Dooley J et al. (1997) Antibiotic prophylaxis in gastrointestinal endoscopy: a report by a Working Party for the British Society of Gastroenterology Endoscopy Committee. Endoscopy 29, 114–120.
- Nakayama T, Ikeda A, Okuda K (1978) Percutaneous transhepatic drainage of the biliary tract: technique and results in 104 patients. Gastroenterology 74, 554–559.
- Hatfield AR, Tobias R, Terblanche J et al. (1982) Preoperative external biliary drainage in obstructive jaundice. A prospective controlled trial. Lancet 2, 896–899.
- McPherson GA, Benjamin IS, Hodgson HJ et al. (1984) Pre-operative percutaneous transhepatic biliary drainage: the results of a controlled trial. Br J Surg 71, 371–375.
- Pitt HA, Gomes AS, Lois JF et al. (1985) Does preoperative percutaneous biliary drainage reduce operative risk or increase hospital costs' Ann Surg 201, 545–553.
- Sewnath ME, Karsten TM, Prins MH et al. (2002) A meta-analysis on the efficacy of preoperative biliary drainage for tumors causing obstructive jaundice. Ann Surg 236, 17–27.
- Lai EC, Mok FP, Fan ST et al. (1994) Preoperative endoscopic drainage for malignant obstructive jaundice. Br J Surg 81, 1195–1198.
- Lai EC, Mok FP, Tan ES et al. (1992) Endoscopic biliary drainage for severe acute cholangitis. N Engl J Med 326, 1582–1586.
- Hoevels J, Nilsson U (1980) Intrahepatic vascular lesions following nonsurgical percutaneous transhepatic bile duct intubation. Gastrointest Radiol 5, 127–135.
- Kama NA, Coskun T, Yuksek YN et al. (1999) Factors affecting post-operative mortality in malignant biliary tract obstruction. Hepatogastroenterology 46, 103–107.
- Dixon JM, Armstrong CP, Duffy SW et al. (1983) Factors affecting morbidity and mortality after surgery for obstructive jaundice: a review of 373 patients. Gut 24, 845–852.