Health Hazards Posed by Dioxin
II
First published: 15 September 2008
Abstract
This article reviews the scientific evidence and methodologies that have been used to assess the human health risks posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It also presents a probabilistic analysis for identifying virtually safe concentrations of TCDD toxicity equivalents (TEQ) in residential soils. Updated data distributions that consider state-of-the-science cancer and noncancer toxicity criteria, child soil ingestion and dermal uptake, bioavailability in soil, and residential exposure duration are incorporated.
References
- 1 National Toxicology Program (2004). Draft NTP technical report on the toxicology and carcinogenesis studies of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in female Harlan Sprague-Dawley rats (Gavage study), NTP TR 521, NIH Publication No. 04-4455, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health.
- 2 Walker, N.J., Crockett, P.W., Nyska, A., Brix, A.E., Jokinen, M.P., Sells, D.M., Hailey, J.R., Easterling, M., Haseman, J.K., Yin, M., Wyde, M.E., Bucher, J.R. & Portier, C.J. (2005). Dose-additive carcinogenicity of a defined mixture of “dioxin-like compounds”, Environmental Health Perspectives 113(1), 43–48.
- 3 Popp, J.A., Crouch, E. & McConnell, E.E. (2006). A weight-of-evidence analysis of the cancer dose-response characteristics of 2,3,7,8-tetrachlorodibenzodioxin (TCDD), Toxicological Sciences 89(2), 361–369.
- 4 Faust, J.B. & Zeise, L. (2004). A reassessment of the carcinogenic potency of 2,3,7,8-tetrachlorodibenzo-p-dioxin based upon a recent long-term study in female rats, Proceedings of the Society for Risk Analysis Annual Meeting, Palm Springs, December 5–8, 2004.
- 5 van Leeuwen, F.X., Feeley, M., Schrenk, D., Larsen, J.C., Farland, W. & Younes, M. (2000). Dioxins: WHO's tolerable daily intake (TDI) revisited, Chemosphere 40(9–11), 1095–1101.
- 6 Schecter, A., Cramer, P., Boggess, K., Stanley, J., Papke, O., Olson, J., Silver, A. & Schmitz, M. (2001). Intake of dioxins and related compounds from food in the U.S. population, Journal of Toxicology and Environmental Health, Part A 63(1), 1–18.
- 7 European Commission Scientific Committee on Food (2001). Opinion of the Scientific Committee on Food on the Risk Assessment of Dioxins and Dioxin-like Food, Health and Consumer Protection Directorate General, Brussels, CS/CNTM/DIOXIN/20final, at http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html.
- 8 CoT (2001). Committee on Toxicity and Chemicals in Food, Consumer Products and the Environment, Statement on the Tolerable Daily Intake for Dioxins and Dioxin-like Polychlorinated Biphenyls, COT/2001/07, at http://www.food.gov.uk/science/ouradvisors/toxicity/statements/coststatements2001/dioxinsstate.
- 9 Becher, H. & Flesch-Janys, D. (1998). Dioxins and furans: epidemiologic assessment of cancer risks and other human health effects, Environmental Health Perspectives 106,Suppl. 2 623–624.
- 10 Becher, H., Steindorf, K. & Flesch-Janys, D. (1998). Quantitative cancer risk assessment for dioxins using an occupational cohort, Environmental Health Perspectives 106,Suppl. 2 663–670.
- 11 Starr, T.B. (2001). Significant shortcomings of the U.S. environmental protection agency's latest draft risk characterization for dioxin-like compounds, Toxicological Sciences 64(1), 7–13.
- 12 Steenland, K., Calvert, G., Ketchum, N. & Michalek, J. (2001). Dioxin and diabetes mellitus: an analysis of the combined NIOSH and ranch hand data, Occupational and Environmental Medicine 58(10), 641–648.
- 13 Steenland, K., Deddens, J. & Piacitelli, L. (2001). Risk assessment for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on an epidemiologic study, American Journal of Epidemiology 154(5), 451–458.
- 14 Crump, K.S., Canady, R. & Kogevinas, M. (2003). Meta-analysis of dioxin cancer dose response for three occupational cohorts, Environmental Health Perspectives 111(5), 681–687.
- 15 Aylward, L.L., Brunet, R.C., Carrier, G., Hays, S.M., Cushing, C.A., Needham, L.L., Patterson, D.G., Gerthoux, P.M., Brambilla, P. & Mocarelli, P. (2005). Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort, Journal of Exposure Analysis and Environmental Epidemiology 15(1), 51–65.
- 16 Aylward, L.L., Brunet, R.C., Starr, T.B., Carrier, G., Delzell, E., Cheng, H. & Beall, C. (2005). Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of elimination, Risk Analysis 25(4), 945–956.
- 17 Aylward, L.L., Lamb, J.C. & Lewis, S.C. (2005). Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds, Toxicological Sciences 87(1), 3–10.
- 18 U.S. Environmental Protection Agency (2003). Draft Exposure and Human Health Risk Assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Parts I, II, and III, Washington, DC, at http://www.epa.gov/ncea/pdfs/dioxin/nas-review/.
- 19 Williams, P. & Paustenbach, D.J. (2002). Risk characterization: principles and practice, Journal of Toxicology and Environmental Health, Part B: Critical Reviews 5(4), 337–406.
- 20 IARC (1997). Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans, IARC Monograph Evaluating Carcinogen Risks in Humans.
- 21 Agency for Toxic Substances and Disease Registry (ATSDR) (1998). Toxicological Profile for Chlorinated Dibenzo-p-dioxins, Atlanta.
- 22 De Rosa, C.T., Brown, D., Dhara, R., Garrett, W., Hansen, H., Holler, J., Jones, D., Jordan-Izaguirre, D., O'Conner, R., Pohl, H. & Xintaras, C. (1999). Dioxin and dioxin-like compounds in soil, part II: technical support document for ATSDR policy guideline, Toxicology and Industrial Health 6, 558–576.
- 23 De Rosa, C.T., Brown, D., Dhara, R., Garrett, W., Hansen, H., Holler, J., Jones, D., Jordan-Izaguirre, D., O'Conner, R., Pohl, H. & Xintaras, C. (1999). Dioxin and dioxin-like compounds in soil, part I: ATSDR policy guideline, Toxicology and Industrial Health 15(6), 552–557.
- 24 Adami, H.O., Cole, P., Mandel, J., Pastides, H., Starr, T.B. & Trichopoulos, D. (2000). Dioxin and cancer, CCC Sponsored Dioxin Workshop, ISRTP and the American Bar Association.
- 25 Feeley, M. & Brouwer, A. (2000). Health risks to infants from exposure to PCBs, PCDDs and PCDFs, Food Additives and Contaminants 17(4), 325–333.
- 26 Sweeney, M.H. & Mocarelli, P. (2000). Human health effects after exposure to 2,3,7,8-TCDD, Food Additives and Contaminants 17, 303–316.
- 27 Adami, H.O., Day, N.E., Trichopoulos, D. & Willett, W.C. (2001). Primary and secondary prevention in the reduction of cancer morbidity and mortality, European Journal of Cancer 37,Suppl. 8 S118–S127.
- 28 Kogevinas, M. (2001). Human health effects of dioxins: cancer, reproductive and endocrine system effects, Human Reproduction Update 7(3), 331–339.
- 29 Smith, A.H. & Lopipero, P. (2001). Invited commentary: how do the Seveso findings affect conclusions concerning TCDD as a human carcinogen? American Journal of Epidemiology 153, 1045–1047.
- 30 Starr, T.B. (2001). Significant shortcomings of the U.S. environmental protection agency's latest draft risk characterization for dioxin-like compounds, Toxicological Sciences 64, 7–13.
- 31 WHO (2001). Joint FAO/WHO Expert Committee on Food Additives (JECFA), Food and Agriculture Organization of the United Nations, Rome.
- 32 Pohl, H., Hicks, H.E., Jones, D.E., Hansen, H. & De Rosa, C.T. (2002). Public health perspectives on dioxin risks: two decades of evaluations, Human and Ecological Risk Assessment 8(2), 233–250.
- 33 Greene, J.F., Hays, S.M. & Paustenbach, D. (2003). Basis for a proposed reference dose (RfD) for dioxin of 1–10 pg/kg-day: a weight of evidence evaluation of the human and animal studies, Journal of Toxicology and Environmental Health, Part B 6, 115–159.
- 34 USEPA (2003). Draft Exposure and Human Health Risk Assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Parts I, II and III, Office of Research and Development, National Center for Environmental Assessment, Exposure Assessment and Risk Characterization Group, Washington, DC.
- 35 Poland, A.P., Smith, D. & Metter, G. (1971). A health survey of workers in a 2,4-D and 2,4,5-T plan with special attention to chloracne, porphyria cutanea tarda, and psychologic parameters, Archives of Environmental Health 22(3), 316–327.
- 36 Caramaschi, F., del Corno, G., Favaretti, C., Giambelluca, S.E., Montesarchio, E. & Fara, G.M. (1981). Chloracne following environmental contamination by TCDD in Seveso, Italy, International Journal of Epidemiology 10(2), 135–143.
- 37 Baccarelli, A., Pesatori, A.C., Consonni, D., Mocarelli, P., Patterson, D.G., Caporaso, N.E., Bertazzi, P.A. & Landi, M.T. (2005). Health status and plasma dioxin levels in chloracne cases 20 years after the Seveso, Italy accident, British Journal of Dermatology 152(3), 459–465.
- 38 Bertazzi, P.A., Pesatori, A.C. & Zocchetti, C. (1998). Seveso-dioxin: an example of environmental medicine. Epidemiologic data as guidelines for health programming, Giornale Italiano di Medicina del Lavoro ed Ergonomia 20, 194–196.
- 39 DeCaprio, A.P., McMartin, D.N., O'Keefe, P.W., Rej, R., Silkworth, J.B. & Kaminsky, L.S. (1986). Subchronic oral toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the guinea pig: comparisons with a PCB-containing transformer fluid pyrolysate, Fundamental and Applied Toxicology 6, 454–463.
- 40 Schantz, S.L., Ferguson, S.A. & Bowman, R.E. (1992). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on behavior of monkey in peer groups, Neurotoxicology and Teratology 14, 433–446.
- 41 Greene, J.F., Hays, S. & Paustenbach, D. (2003). Basis for a proposed reference dose (RfD) for dioxin of 1–10 pg/kg-day: a weight of evidence evaluation of the human and animal studies, Journal of Toxicology and Environmental Health, Part B: Critical Reviews 6(2), 115–159.
- 42 Reggiani, G. (1978). Medical problems raised by the TCDD contamination in Seveso, Italy, Archives of Toxicology 40, 161–188.
- 43 Caramaschi, F., del Corno, G., Favaretti, C., Giambelluca, S.E., Montesarchio, E. & Fara, G.M. (1981). Chloracne following environmental contamination by TCDD in Seveso, Italy, International Journal of Epidemiology 10, 135–143.
- 44 Ideo, G., Bellati, D., Bellobuono, A. & Bissanti, L. (1985). Urinary D-glucaric acid excretion in the Seveso area, polluted by tetrachlorodibenzo-p-dioxin (TCDD): five years of experience, Environmental Health Perspectives 60, 151–157.
- 45 Mocarelli, P., Marocchi, A., Brambilla, P., Gerthoux, P.M., Young, D.S. & Mantel, N. (1986). Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy, Journal of the American Medical Association 256, 2687–2695.
- 46 Assennato, G., Cervino, D., Emmett, E.A., Longo, G. & Merlo, F. (1989). Follow-up of subjects who developed chloracne following TCDD exposure at Seveso, American Journal of Industrial Medicine 16, 119–125.
- 47 Mably, T.A., Bjerke, D.L., Moore, R.W., Gendron-Fitzpatrick, A. & Peterson, R.E. (1992). In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). 3. Effects on spermatogenesis and reproductive capability, Toxicology and Applied Pharmacology 114, 118–126.
- 48 Gray, L.E., Ostby, J.S. & Kelce, W.R. (1997). A dose-response analysis of the reproductive effects of a single gestational dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male Long Evans hooded rat offspring, Toxicology and Applied Pharmacology 146, 11–20.
- 49 Gray, L.E., Wolf, C., Mann, P. & Ostby, J.S. (1997). In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive development of female Long Evans hooded rat offspring, Toxicology and Applied Pharmacology 146, 237–244.
- 50 Faqi, A.S. & Chahoud, I. (1998). Antiestrogenic effects of low doses of 2,3,7,8-TCDD in offspring of female rats exposed throughout pregnancy and lactation, Bulletin of Environmental Contamination and Toxicology 61, 462–469.
- 51 Faqi, A.S., Dalsenter, P.R., Merker, H.J. & Chahoud, I. (1998). Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation, Toxicology and Applied Pharmacology 150, 383–392.
- 52 Ostby, J.S., Price, M., Huey, O., Hurst, C., Birnbaum, L. & Gray Jr, L.E. (1999). Developmental and reproductive effects of low-dose, steady-state maternal 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) administration, Society of Toxicology 38th Annual Meeting, March 14–18, 1999, New Orleans.
- 53 Ohsako, S., Miyabara, Y., Nishimura, N., Kurosawa, S., Sakaue, M., Ishimura, R., Sato, M., Takeda, K., Aoki, Y., Sone, H., Tohyama, C. & Yonemoto, J. (2001). Maternal exposure to a low dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppressed the development of reproductive organs of make rats: dose-dependent increase of mRNA levels of 5-alpha-reductase type 2 in contrast to decrease of androgen receptor in the pubertalventral prostate, Toxicological Sciences 60, 132–143.
- 54 WHO (2000). Assessment of the health risk of dioxins: re-evaluation of the tolerable daily intake (TDI), in Organized by WHO European Centre for Environment and Health and International Programme on Chemical Safety, Food Additives and Contaminants, F.X.R. Leeuwen & M.M. Younes, eds, Taylor & Francis, London, Vol. 17, pp. 233–369.
- 55 Renwick, A. (2004). Recent risk assessments of dioxin, 24th International Symposium on Halogenated Environmental Organic Pollutants and POPs, Berlin.
- 56 NAS (2006). Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment, National Academy Press, Washington, DC.
- 57 Kociba, R.J., Keyes, D.G., Lisowe, R.W., Kalnins, R.P., Dittenber, D.D., Wade, C.E., Gorzinski, S.J., Mahle, N.H. & Schwetz, B.A. (1978). Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats, Toxicology and Applied Pharmacology 46(2), 279–303.
- 58 van den Berg, M., Birnbaum, L., Bosveld, A.T.C., Brunstrom, B., Cook, P., Feeley, M., Giesy, J.P., Hanberg, A., Hasegawa, R., Kennedy, S.W., Kubiak, T., Larsen, J.C., van Leeuwen, F.X.R., Liem, A.K.D., Nolt, C., Peterson, R.E., Poellinger, L., Safe, S., Schrenk, D., Tillitt, D., Tysklind, M., Younes, M., Waern, F. & Zacharewski, T. (1998). Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife, Environmental Health Perspectives 106(12), 775–792.
- 59 Sielken, R.L. (1987). Quantitative cancer risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), Food and Chemical Toxicology 25(3), 257–267.
- 60 Connor, K. & Aylward, L.L. (2005). Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR, Journal of Toxicology and Environmental Health, Part B 9(2), 147–171.
- 61 Paustenbach, D.J. (2002). The USEPA science advisory board evaluation of the EPA (2001) dioxin reassessment, Regulatory Toxicology and Pharmacology 36, 211–219.
- 62 Bodner, K.M., Collins, J.J., Bloemen, L.J. & Carson, M.L. (2003). Cancer risk for chemical workers exposed 2,3,7,8-tetrachlorodibenzo-p-dioxin, Occupational and Environmental Medicine 60(9), 672–675.
- 63 Aylward, L.L., Brunet, R.C., Carrier, G., Hays, S.M., Cushing, C.A., Needham, L.L., Patterson, D.G., Gerthoux, P.M., Brambilla, P. & Mocarelli, P. (2005). Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort, Journal of Exposure Analysis and Environmental Epidemiology 15(1), 51–65.
- 64 van den berg, M., Birnbaum, L.S., Denison, M., De Vito, M., Farland, W., Feeley, M., Fiedler, H., Hakansson, H., Hanberg, A., Haws, L., Rose, M., Safe, S., Schrenk, D., Toyama, C., Tritscher, A., Tuomisto, J., Tysklind, M., Walker, N. & Peterson, R.E. (2006). The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds, Toxicological Sciences 93(2), 223–241.
- 65 Safe, S. (1998). Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds, Teratogenesis, Carcinogenesis, and Mutagenesis 17, 285–304.
- 66 Finley, B.L., Connor, K.T. & Scott, P.K. (2003). The use of toxic equivalency factor distributions in probabilistic risk assessments for dioxins, furans, and PCBs, Journal of Toxicology and Environmental Health 66(6), 533–550.
- 67 Haws, L., Harris, M., Su, S., Birnbaum, L., DeVito, M.J., Farland, W., Walker, N., Connor, K., Santamaria, A. & Finley, B. (2004). Development of a refined database of relative potency estimates to facilitate better characterization of variability and uncertainty in the current mammalian TEFs for PCDDs, PCDFs and dioxin-like PCBs, Organohalogen Compounds 66, 3426–3432.
- 68 Portier, C. (2000). Risk ranges for various endpoints following exposure to 2,3,7,8-TCDD, Food Additives and Contaminants 17(4), 335–346.
- 69 Safe, S. (2001). Molecular biology of the Ah receptor and its role in carcinogenesis, Toxicology Letters 120(1–3), 1–7.
- 70 Starr, T.B., Greenlee, W.F., Neal, R.A., Poland, A. & Sutter, T.R. (1999). The trouble with TEFs, Environmental Health Perspectives 107, A492–A493.
- 71 Yoshizawa, K., Walker, N.J., Jokinen, M.P., Brix, A.E., Sells, D.M., Marsh, T., Wyde, M.E., Orzech, D., Haseman, J.K. & Nyska, A. (2005). Gingival carcinogenicity in female Harlan Sprague-Dawley rats following two-year oral treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin and dioxin-like compounds, Toxicological Sciences 83(1), 64–77.
- 72 Bannister, R., Davis, D., Zacharewski, T., Tizard, I. & Safe, S. (1987). Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: effect on enzyme induction and immunotoxicity, Toxicology 46(1), 29–42.
- 73 Bannister, R., Biegel, L., Davis, D., Astroff, B. & Safe, S. (1989). 6-Methyl-1,3,8-trichlorodibenzofuran (MCDF) as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6 mice, Toxicology and Applied Pharmacology 54(2), 139–150.
- 74 Biegel, L., Harris, M., Davis, D., Rosengren, R., Safe, L. & Safe, S. (1989). 2,2′,4,4′,5,5′-Hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice, Toxicology and Applied Pharmacology 97(3), 561–571.
- 75 Davis, D. & Safe, S. (1989). Dose-response immunotoxicities of commercial polychlorinated biphenyls (PCBs) and their interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, Toxicology Letters 48(1), 35–43.
- 76 Davis, D. & Safe, S. (1990). Immunosuppressive activities of polychlorinated biphenyl in C57BL/6N mice: structure-activity relationships as Ah receptor agonists and partial antagonists, Toxicology 63(1), 97–111.
- 77 Harper, N., Connor, K., Steinberg, M. & Safe, S. (1995). Immunosuppressive activity of polychlorinated biphenyl mixtures and congeners: nonadditive (antagonistic) interactions, Fundamental and Applied Toxicology 27(1), 131–139.
- 78 Safe, S. (1998). Hazard and risk assessment of chemical mixtures using the toxic equivalency factor approach, Environmental Health Perspectives 106,Suppl. 4 1051–1058.
- 79 Connor, K., Harris, M., Edwards, M., Chu, A., Clark, G. & Finley, B. (2004). Estimating the total TEQ in human blood from naturally-occurring vs. anthropogenic dioxins: a dietary study, Organohalogen Compounds 66, 3360–3365.
- 80 Calabrese, E. & Baldwin, L.A. (2001). The frequency of U-shaped dose responses in the toxicological literature, Toxicological Sciences 62, 330–338.
- 81 Calabrese, E. & Baldwin, L.A. (2001). Scientific foundations of hormesis, Critical Reviews in Toxicology 31, 4–5.
- 82 Calabrese, E. (2002). Defining hormesis, Human and Experimental Toxicology 21, 91–97.
- 83 USEPA (2000). Draft Exposure and Human Health Risk Assessment of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Parts I, II and III, Office of Research and Development, National Center for Environmental Assessment, Exposure Assessment and Risk Characterization Group, Washington, DC.
- 84 Larsen, J.C., Farland, W. & Winters, D. (2000). Current risk assessment approaches in different countries, Food Additives and Contaminants 17(4), 359–369.
- 85 Ahlborg, U., Hakansson, H., Wern, F. & Hanberg, A. (1988). Nordisk dioxin risk bedornning, Rapport fran en expertgroup, Nord 4:9(Miljorapport):7, Nordisk Ministerrad, Kobenhavn.
- 86 Environmental Protection Agency (1989). Integrated Risk Information System (IRIS) On-line Database Entry for 2,3,7,8-tetrachlorodibenzo-p-dioxin, January 1.
- 87 World Health Organization (1991). Consultation on Tolerable Daily Intake from Food of PCDDs and PCDFs, Copenhagen, Summary Report, Bilthoven, EUR/IPC/PCS 030(S), December 4–7, 1990.
- 88 Agency for Toxic Substances and Disease Registry (ATSDR) (1992). Toxicological Profile for Chlorinated Dibenzo-p-dioxins, Atlanta.
- 89 Health Council of the Netherlands (1996). Committee on the risk evaluation of substances dioxins, Dioxins, Polychlorinated Dibenzo-p-dioxins Dibenzofurans and Dioxin-like Polychlorinated Biphenyls, Publication No: 1996/10, Rijswijks.
- 90 Environmental Agency Japan (1997). Report of Ad Hoc Committee on Dioxin Risk Assessment (Summary in English), at http://www.chem.unep.ch/pops/POPsInc/proceedings/bangkok/KIMURA.html.
- 91 Agency for Toxic Substances and Disease Registry (1997). Interim Policy Guideline: Dioxin and Dioxin-like Compounds in Soil, Atlanta.
- 92 Agency for Toxic Substances and Disease Registry (1997). Technical Support Document for ATSDR Interim Policy Guideline: Dioxin and Dioxin-like Compounds in Soil, Atlanta.
- 93 European Commission, SCoFS (2001). Opinion of the Scientific Committee on Food on the Risk Assessment of Dioxins and Dioxin-Like Food, European Commission, Health and Consumer Protection Directorate General, Brussels.
- 94 Murray, F.J., Smith, F.A., Nitschke, K.D., Humiston, C.G., Kociba, R.J. & Schwetz, B.A. (1979). Three generation reproduction study of rats given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the diet, Toxicology and Applied pharmacology 50, 241–251.
- 95 Rier, S.E., Martin, D.C., Bowman, R.E., Dmowski, W.P. & Becker, J.L. (1993). Endometriosis in rhesus monkeys (Macaca mulatta) following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin, Fundamental and Applied Toxicology 21, 433–441.
- 96 Gehrs, B.C. & Smialowicz, R.J. (1997). Alterations in the developing immune system of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. I. Effects on the fetus and the neonate, Toxicology 122, 219–228.
- 97 Gehrs, B.C., Riddlge, M.M., Williams, W.C. & Smialowicz, R.J. (1997). Alterations in the developing immune systems of the F344 rat after perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. II. Effects on the pup and the adult, Toxicology 122, 229–240.
- 98 U.S. Environmental Protection Agency (2000). Draft Exposure and Human Health Risk Assessment of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds, Parts I, II, and III, USEPA/600/P-00/001Bg, Washington, DC, at http://cfpub.epa.gov/ncea/cfm/part1and2.cfm?AcType=default.
- 99 Cole, P., Trichopoulos, D., Pestides, H., Starr, T.B. & Mandel, J.S. (2003). Dioxin and cancer: a critical review, Regulatory Toxicology and Pharmacology 38, 378–388.
- 100 Aylward, L.L. & Hays, S.M. (2002). Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels, Journal of Exposure Analysis and Environmental Epidemiology 12(5), 319–328.
- 101 Gaylor, D.W. & Aylward, L.L. (2004). An evaluation of benchmark dose methodology for non-cancer continuous-data health effects in animals due to exposures to dioxin (TCDD), Regulatory Toxicology and Pharmacology 40(1), 9–17.
- 102 U.S. Environmental Protection Agency-Science Advisory Board (2001). Dioxin Reassessment: An SAB Review of the Office of Research and Development's Reassessment of Dioxin, USEPA-SAB-EC-01-006, Washington, DC, at http://yosemite.epa.gov/sab/SABPRODUCT.NSF/C3B2E34A9CD7E9388525718D005FD3D2/$File/ec01006.pdf.
- 103 Kerger, B.D., Suder, D.R., Schmidt, C.E. & Paustenbach, D.J. (2005). Airborne exposure to trihalomethanes from tap water in homes with refrigeration-type and evaporative cooling systems, Journal of Toxicology and Environmental Health A 68(6), 401–429.
- 104 Paustenbach, D.J., Leung, H.W., Scott, P.K. & Kerger, B.D. (2004). An approach to calculating childhood body burdens of dibenzodioxins and dibenzofurans which accounts for age-dependent biological half-lives, Organohalogen Compounds 66, 2714–2721.
- 105 Environmental Protection Agency (1989). Risk Assessment Guidance for Superfund, Volume 1: Human Health Evaluation Manual Part A, USEPA/540/1-89/002, Washington, DC.
Further Reading
- Aylward, L.L. & Hays, S.M. (2002). Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels, Journal of Exposure Analysis and Environmental Epidemiology 12(5), 319–328.
Encyclopedia of Quantitative Risk Analysis and Assessment
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