Biodegradation of Polyphosphazenes
Part 9. Miscellaneous Biopolymers and Biodegradation of Polymers
Prof. Kangjie Zhu,
Dr. Liyan Qiu,
Prof. Kangjie Zhu
- [email protected]
- +86-571-87952046 | Fax: +86-571-87951773
Zhejiang University, Department of Polymer Science and Engineering, Hangzhou, People's Republic of China, 310027
Search for more papers by this authorDr. Liyan Qiu
- [email protected]
- +86-571-87217205 | Fax: +86-571-87217086
Zhejiang University, College of Pharmaceutical Sciences, Hangzhou, People's Republic of China, 310031
Search for more papers by this authorProf. Kangjie Zhu,
Dr. Liyan Qiu,
Prof. Kangjie Zhu
- [email protected]
- +86-571-87952046 | Fax: +86-571-87951773
Zhejiang University, Department of Polymer Science and Engineering, Hangzhou, People's Republic of China, 310027
Search for more papers by this authorDr. Liyan Qiu
- [email protected]
- +86-571-87217205 | Fax: +86-571-87217086
Zhejiang University, College of Pharmaceutical Sciences, Hangzhou, People's Republic of China, 310031
Search for more papers by this authorAbstract
- Introduction
- Historical Outline
- Chemical Structures
- Occurrence
- Functions
- Controlled Drug Release
- Hydrophobic Polyphosphazene
- Polyphosphazene Hydrogel
- Polyphosphazene–Drug Conjugations
- Temporary Replacement of Body Parts
- Controlled Drug Release
- Physiology
- Biodegradation
- Hydrophobic Matrix
- Poly[(amino acid ester) Phosphazene]
- Glycolic (lactic) Acid Ester Polyphosphazene
- Depsipeptide Ester Polyphosphazene
- Dipeptide Ester Polyphosphazene
- Amino Acethydroxamic Acid Ester Polyphosphazene
- Water-soluble Matrix
- Imidazolyl Polyphosphazene
- Glyceryl Polyphosphazene
- Glucosyl Polyphosphazene
- Carboxylatophenoxy Polyphosphazene
- Methoxy-poly (ethylene glycol) and Amino Acid Ester Cosubstituted Polyphosphazene
- Polyphosphazene–Drug Conjugation
- Polyphosphazene/methoxy-poly(ethylene glycol)/(diamine)platinum Conjugation
- Polyphosphazene/(diamine)platinum/Saccharide Conjugation
- Schiff Base Coupling of Polyphosphazene to Aldehydes and Amines
- Polyphosphazene with Steroidal Side Groups
- Hydrophobic Matrix
- Products
- Outlook and Perspectives
- Patents
References
- Aldini, N. N., Fini, M., Rocca, M., Martini, L., Giardino, R. (1997) Peripheral nerve reconstruction with bioabsorbable polyphosphazene conduits, J. Bioact. Compat. Polym, 12, 3–13.
- Allcock, H. R. (1976) Polyphosphazenes: new polymers with inorganic backbone atoms, Science 24, 1214–1219.
- Allcock, H. R. (1977) Poly(organophosphazenes)–unusual new high polymers, Angew. Chem. Int. Ed. Engl. 16, 147–156.
- Allcock, H. R. (1980) Polymerization of cyclic phosphazenes, Polymer 21, 673–683.
- Allcock, H. R. (1993a) Water-soluble polyphosphazenes and their hydrogel, Polym. Mater. Sci. Eng. 69, 98–99.
- Allcock, H. R. (1993b) Macromolecular and materials design using polyphosphazene, Polym. Prepr. 34, 261–262.
- Allcock, H. R. (1994) Cross-linking reactions for the conversion of polyphosphazenes into useful materials, Chem. Mater. 6, 1476–1491.
- Allcock, H. R. (1997) Functional polyphosphazenes, Polym. Mater. Sci. Eng. 76, 49–50.
- Allcock, H. R. (2000) New developments in the science and applications of polyphosphazenes, Polym. Prepr. 41, 553.
- Allcock, H. R., Ambrosio, A. M. A. (1996) Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels, Biomaterials 17, 2295–2302.
- Allcock, H. R., Ambrosio, A. (2000) Synthesis and characterization of pH-sensitive poly(organophosphazene) hydrogels, Polym. Prepr. 41, 732.
- Allcock, H. R., Austin, P. E. (1981) Schiff base coupling of cyclic and high-polymeric phosphazenes to aldehydes and amines: chemotherapeutic models, Macromolecules 14, 1616–1622.
- Allcock, H. R., Fuller, T. J. (1980) Phosphazene high polymers with steroidal side groups, Macromolecules 13, 1338–1345.
- Allcock, H. R., Fuller, T. J. (1981) Synthesis and hydrolysis of hexakis(imidazolyl)cyclotriphosphazene, J. Am. Chem. Soc. 103, 2250–2256.
- Allcock, H. R., Kwon, S. (1988) Glyceryl polyphosphazenes: synthesis, properties, and hydrolysis, Macromolecules 21, 1980–1985.
- Allcock, H. R., Kwon, S. (1989) An ionically cross-linkable polyphosphazene: poly[bis(carboxylatophenoxy)phosphazene] and its hydrogels membranes, Macromolecules 22, 75–79.
- Allcock, H. R., Pucher, S. R. (1991) Polyphosphazenes with glycosyl and methylamino, trifluoroethoxy, phenoxy, or (methoxyethoxy)ethoxy side groups, Macromolecules 21, 23–34.
- Allcock, H. R., Scopelianos, A. G. (1983) Synthesis of sugar-substituted cyclic and polymeric phosphazenes and their oxidation, reduction, and acetylation reactions, Macromolecules 16, 715–719.
- Allcock, H. R., Gardner, J. E., Smeltz, K. M. (1975) Polymerization of hexachlorocyclotriphosphazene. The role of phosphorus pentachloride, water, and hydrogen chloride, Macromolecules, 8, 36–42.
- Allcock, H. R., Fuller, T. J., Mack, D. P., Matsumura, K., Smeltz, K. M. (1977) Poly[(amino acid alkyl ester)phosphazene], Macromolecules 10, 824–830.
- Allcock, H. R., Fuller, T. J., Matsumura, K., Austin, P. E. (1980) Polyphosphazenes as carrier molecules for controlled release systems, Polym. Prepr. 21, 111–112.
- Allcock, H. R., Fuller, T. J., Matsumura, K. (1982) Hydrolysis pathways for aminophosphazenes, Inorg. Chem. 21, 515–521.
- Allcock, H. R., Kwon, S., Pucher, S. R. (1990) Bioerodible polymers with a phosphorus-nitrogen backbone, Polym. Prepr. 31, 180.
- Allcock, H. R., Pucher, S. R., Scopelianos, A. G. (1994a) Poly[(amino acid ester)phosphazenes] as substrates for the controlled release of small molecules, Biomaterials 15, 563–569.
- Allcock, H. R., Pucher, S. R., Scopelianos, A. G. (1994b) Synthesis of poly(organophosphazenes) with glycolic acid ester and lactic acid ester side groups: prototypes for new bioerodible polymers, Macromolecules 27, 1–4.
- Allcock, H. R., Pucher, S. R., Scopelianos, A. G. (1994c) Poly[(amino acid ester)phosphazenes]: synthesis, crystallinity, and hydrolytic sensitivity in solution and the solid state, Macromolecules 27, 1071–1075.
- Andrianov, A. K., Cohen, S., Visscher, K. B., Payne, L. G., Allcock, H. R., Langer, R. (1993a) Controlled release using ionotropic polyphosphazene hydrogels, J. Control. Release 27, 69–77.
- Andrianov, A. K., Payne, L. G., Visscher, K. B., Allcock, H. R., Langer, R. (1993b) Hydrolytic degradation of polyphosphazene hydrogels, Polym. Prepr. 34, 233–234.
- Andrianov, A. K., Payne, L. G., Visscher, K. B., Allcock, H. R., Langer, R. (1994) Hydrolytic degradation of ionically cross-linked polyphosphazene microspheres, J. Appl. Polym. Sci. 53, 1573–1578.
- Andrianov, A. K., Chen, J. P., Payne, L. G. (1997a) Preparation of polyphosphazene hydrogel microspheres by coacervation, Polym. Mater. Sci. Eng. 76, 365–366.
- Andrianov, A. K., Legolvan, M. P., Sule, S. S., Payne, L. G. (1997b) Degradation of poly[di(carboxylatophenoxy)phosphazene] in aqueous solution, Polym. Mater. Sci. Eng. 76, 369–370.
- Andrianov, A. K., Chen, J. P., Payne, L. G. (1998a) Preparation of hydrogel microspheres by caocervation of aqueous polyphosphazene solutions, Biomaterials 19, 109–115.
- Andrianov, A. K., Sargent, J. R., Sule, S. S., Legolvan, M. P., Woods, A. L., Jenkins, S. A., Payne, L. G. (1998b) Physico-chemical properties and immunoadjuvant activity of water-soluble phosphazene polyacids, Polym. Prepr. 39, 2–3.
- Caliceti, P., Aldini, N. N., Fini, M., Rocca, M., Gnudi, S., Lora, S., Giavaresi, G., Monfardini, C., Giardino, R., Veronese, F. M. (1997) Bioabsorbable polyphosphazene matrices as systems for calcitonic controlled release, Farmaco 52, 697–702.
- Caliceti, P., Veronese, F. M., Lora, S. (2000) Polyphosphazene microspheres for insulin delivery, Inter. J. Pharm. 211, 57–65.
- Chang, Y., Lee, S. C., Kim, K. T., Kim, C., Reeves, S. D., Allcock, H. R. (2001) Synthesis and micellar characterization of an amphiphilic diblock copolyphosphazene, Macromolecules 34, 269–274.
- Cohen, S., Bano, M. C., Visscher, K. B., Chow, M., Allcock, H. R., Langer, R. (1990) Ionically cross-linkable polyphosphazene: a novel polymer for microencapsulation, J. Am. Chem. Soc. 112, 7832–7833.
- Crommen, J. H. L., Schacht, E. H., Mense, E. H. G. (1992a) Biodegradable polymers I. Synthesis of hydrolysis-sensitive poly[(organo)phosphazenes], Biomaterials 13, 511–520.
- Crommen, J. H. L., Schacht, E. H., Mense, E. H. G. (1992b) Biodegradable polymers II. Degradation characteristics of hydrolysis-sensitive poly[(organo)phosphazenes], Biomaterials 13, 601–611.
- Crommen, J., Vandorpe, J., Schacht, E. (1993) Degradable polyphosphazenes for biomedical applications, J. Control. Release 24, 167–180.
- Goedemoed, J. H., Groot, K. D., Claessen, A. M. E., Scheper, R. J. (1991a) Development of implantable antitumor devices based on polyphosphazenes II, J. Control. Release 17, 235–244.
- Goedemoed, J. H., Mense, E. H. G., Groot, K. D., Claessen, A. M. E., Scheper, R. J. (1991b) Development of injectable antitumor microspheres based on polyphosphazene, J. Control. Release 17, 245–258.
- Ibim, S. M., Ambrosio, A. A., Larrier, D., Allcock, H. R., Laurencin, C. T. (1996) Controlled macromolecule release from poly(phosphazene) matrices, J. Control. Release 40, 31–39.
- Kim, C., Chang, Y., Lee, S. C., Allcock, H. R., Reeves, S. D. (2000) An amphiphilic diblock copolyphosphazene: synthesis and micellar characteristics in aqueous phase, Polym. Prepr. 41, 609–610.
- Langone, F., Lora, S., Veronese, F. M., Caliceti, P., Parnigotto, P. P., Malenti, F., Palma, G. (1995) Peripheral nerve repair using a poly(organo)phosphazene tubular prosthesis, Biomaterials 16, 347–353.
- Laurencin, C. T., Koh, H. J., Neenan, T. X., Allcock, H. R., Langer, R. (1987) Controlled release using a new bioerodible polyphosphazene matrix system, J. Biomed. Mater. Res. 21, 1231–1246.
- Laurencin, C. T., Norman, M. E., Elgendy, H. M., El-amin, S. E., Allcock, H. R., Pucher, S. R. (1993) Use of polyphosphazenes for skeletal tissue regeneration, J. Biomed. Mater. Res. 27, 963–973.
- Lee, S. B., Song, S. C., Jin, J. I., Sohn, Y. S. (1999) Synthesis and antitumor activity of polyphosphazene/methoxy-poly(ethylene glycol)/(diamine)platinum(II) conjugates, Polym. J. 31, 1247–1252.
- Passi, P., Zadro, A., Marsilio, F., Lora, S., Caliceti, P., Veronese, F. M. (2000) Plain and drug loaded polyphosphazene membranes and microspheres in the treatment of rabbit bone defects, J. Mater. Sci.: Mater. Med. 11, 643–654.
- Payne, L. G., Jenkins, S. A., Woods, A. L., Grund, E. M., Geribo, W. E., Loebelenz, J. R., Andrianov, A. K., Roberts, B. E. (1998) Poly[di(carboxylatophenoxy)phosphazene] (PCPP) is a potent immunoadjuvant for an influenza vaccine, Vaccine 16, 92–98.
- Qiu, L. Y., Zhu, K. J. (2000) Novel biodegradable polyphosphazenes containing glycine ethyl ester and benzyl ester of amino acethydroxamic acid as cosubstituents: syntheses, characterization, and degradation properties, J. Appl. Polym. Sci. 77, 2987–2995.
- Ruiz, E. M., Ramirez, C. A., Aponte, M. A., Barbosa-Canovas, G. V. (1993) Degradation of poly[bis(glycine ethyl ester)phosphazene] in aqueous media, Biomaterials 14, 491–496.
- Song, S. C., Sohn, Y. S. (1998) Synthesis and hydrolytic properties of polyphosphazene/ (diamine)platinum/saccharide conjugates, J. Control. Release 55, 161–170.
- Song, S. C., Lee, C. O., Sohn, Y. S. (1999a) A novel polymeric conjugate carrying two different anticancer drugs, Polym. Inter. 48, 627–629.
- Song, S. C., Lee, S. B., Jin, J., Sohn, Y. S. (1999b) A new class of biodegradable thermosensitive polymers. I. Synthesis and characterization of poly(organophosphazenes) with methoxy-poly(ethylene glycol) and amino acid esters as side groups, Macromolecules 32, 2188–2193.
- Song, S. C., Lee, S. B., Jin, J., Sohn, Y. S. (1999c) A new class of biodegradable thermosensitive polymers. 2. hydrolytic properties and salt effect on the lower critical solution temperature of poly(organophosphazenes) with methoxypoly(ethylene glycol) and amino acid esters as side groups, Macromolecules 32, 7820–7827.
- Veronese, F. M., Marsilio, F., Caliceti, P., Filippis, P. D., Giunchedi, P., Lora, S. (1998) Polyorganophosphazene microspheres for drug release: polymer synthesis, microsphere preparation, in vitro and in vivo naproxen release, J. Control. Release 52, 227–237.
- Veronese, F. M., Marsilio, F., Lora, S., Caliceti, P., Passi, P., Orsolini, P. (1999) Polyphosphazene membranes and microspheres in periodontal diseases and implant surgery, Biomaterials 20, 91–98.
Citing Literature
Biopolymers Online: Biology • Chemistry • Biotechnology • Applications
Browse other articles of this reference work: