Biodegradation of Poly(alkylcyanoacrylates)

Part 9. Miscellaneous Biopolymers and Biodegradation of Polymers
Dr. Christine Vauthier

Dr. Christine Vauthier

Université de Paris XI, Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, 5 Rue Jean Baptiste Clément, Chatenay-Malabry Cedex, France, 92 296

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Prof. Patrick Couvreur

Prof. Patrick Couvreur

Université de Paris XI, Laboratoire de Physico-chimie, Pharmacotechnie et Biopharmacie, UMR CNRS 8612, 5 Rue Jean Baptiste Clément, Chatenay-Malabry Cedex, France, 92 296

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First published: 15 January 2005
Citations: 3

Abstract

  • Introduction
  • Historical Outline
  • Synthesis and Purification of Alkylcyanoacrylate Monomers
  • Polymer Synthesis
    • General Considerations
    • Bulk Polymerization
    • Polymerization in Organic Solvents
    • Emulsion Polymerization: Preparation of Matricial PACA Nanoparticles (Nanospheres)
    • Interfacial Polymerization: Preparation of Reservoir-Type PACA Nanoparticles (Nanocapsules)
    • Synthesis of Amphiphilic Block Copolymers Containing PACA Segments
    • World Market
  • Characterization and Methods of Analysis
  • Stability and Mechanism of Degradation
  • Toxicity
  • Application of PACA in the Design of Drug Delivery Systems
    • Use of “Conventional” PACA Nanoparticles
      • Treatment of Cancer
      • Controlled Delivery of Peptides and Proteins
      • Delivery of Oligonucleotides
      • Delivery of Anti-Infectious Agents
      • PACA Nanospheres in Ocular Therapy
    • From “Conventional” to Targeted Systems
  • Patent Overview
  • Outlook and Perspectives

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