Inulin
Part 6. Polysaccharides
Dr. Anne Franck,
Ir. Leen De Leenheer,
Dr. Anne Franck
- [email protected]
- +32-16-801-218 | Fax: +32-16-801-359
ORAFTI, Aandorenstraat 1, Tienen, Belgium, 3300
Search for more papers by this authorIr. Leen De Leenheer
- [email protected]
- +-32-16-801-351 | Fax: +32-16-801-496
ORAFTI, Aandorenstraat 1, Tienen, Belgium, 3300
Search for more papers by this authorDr. Anne Franck,
Ir. Leen De Leenheer,
Dr. Anne Franck
- [email protected]
- +32-16-801-218 | Fax: +32-16-801-359
ORAFTI, Aandorenstraat 1, Tienen, Belgium, 3300
Search for more papers by this authorIr. Leen De Leenheer
- [email protected]
- +-32-16-801-351 | Fax: +32-16-801-496
ORAFTI, Aandorenstraat 1, Tienen, Belgium, 3300
Search for more papers by this authorAbstract
- Introduction
- Historical Outline
- Chemical Structure
- Natural Occurrence
- Physiological Function
- Chemical Analysis and Detection
- High-performance Liquid Chromatography (HPLC)
- Gas Chromatography
- HPAEC Analysis (Dionex)
- Permethylation
- Quantitative Determination of Inulin and Oligofructose in Food
- Quantitative Determination of Inulin in Food
- Biosynthesis
- Synthesis of Microbial Fructan
- In vitro Synthesis of FOS
- Synthesis of Inulin from Plant Origin (Asteraceae)
- Biochemistry
- Molecular Genetics
- Biodegradation
- Plant Endogenous Degradation
- Biochemistry
- Molecular Genetics
- In vitro Hydrolysis by Yeast and Mold Enzymes
- Plant Endogenous Degradation
- Production
- FOS Production Starting from Sucrose
- Commercial Inulin of Plant Origin
- Agricultural Aspects
- Processing
- Commercial Production of Inulin and FOS
- Scale of Production
- Properties
- Physical and Chemical Properties
- Material Properties
- Biological Properties
- Nondigestibility
- Caloric Value
- Improvement of Lipid Metabolism
- Effects on Gut Function
- Modulation of Gut Microflora
- Suitability for Diabetics
- Reduction of Cancer Risk
- Increase in Mineral Absorption
- Intestinal Acceptability
- Food Applications
- Non-food Developments and Applications
- Outlook and Perspectives
- Patents
- Acknowledgements
References
- Absolonne, J., Jossart, M., Coussement, P., Roberfroid, M. (1995) Digestive acceptability of oligofructose, Proceedings, First ORAFTI Research Conference, Brussels, 151–160.
- Ajinomoto (1992) Liquid composition containing polyfructan, polyfructan production by Aspergillus sydowii fermentation or by fructose-transferase action on sugar or inulin, Patent Application JP4311378.
- Ajinomoto (1992) Solid composition containing polyfructan, polyfructan production by Aspergillus sydowii fermentation or by fructose-transferase action on sugar or inulin, Patent Application JP4311371.
- Andre, I., Putaux, J. L., Chanzy, H., Taravel, F. R., Timmermans, J. W., de Wit, D. (1996) Single crystals of inulin, Int. J. Biol. Macromol. 18, 195–204.
- Baillargé, E. (1942) Le topinambour, ses usages, sa culture, in: La Terre Encyclopédie Paysanne ( Flammarion, Ed.).
- Beringer, A., Wenger, R. (1955) Inulin in der Ernährung des Diabetikers, Dtsch. Z. Verdauungs- u. Stoffwechselkrankh. 15, 268–272.
- Besemer, A. C. (1993) The bromide-catalyzed hypochlorite oxidation of starch and inulin. Calcium complexation of oxidized fructans, PhD Thesis, Delft University of Technology, The Netherlands.
- Besemer, A. C., van Bekkum, H. (1994) The hypochlorite oxidation of inulin, Recl. Trav. Chim. 113, 398–402.
- Bhattathiry, E. P. M. (1971) Effects of polysaccharides on the biosynthesis of lipids in adult rats, Far East Med. J., 7, 187–190.
- Birch, G. G., Soon, E. B. T. (1973) Composition and properties of diabetic jams, Confect. Prod. 39, 73–76.
- Booten, K., De Soete, J., Frippiat, A. (1998) Fructan-and/ or polydextrose-containing dairy powders, process for preparing same and their use, Patent Application EP 821 885.
- Brighenti, F., Casiraghi, M. C., Canzi, E., Ferrari, A. (1999) Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers, Eur. J. Clin. Nutr. 53, 726–733.
- Butel, M., Roland, N., Hibert, A., Papot, F., Favre, A., Tessedre, A., Bensaada, M., Rimbault, A., Szylit, O. (1998) Clostridial pathogenicity in experimental necrotising enterocolitis in gnotobiotic quails and protective role of bifidobacteria, J. Med. Microbiol. 47, 391–399.
- Caimi, P. G., Hershey, H. P., Kerr, P. S. (1995) Fructose polymers are produced by transgenic crop plants fructan, dextran, alternan production in maize, potato and tobacco; DNA construct containing tissue-specific promoter, vacuole targeting sequence and fructosyltransferase gene, Patent Application WO 95 13389.
- Cairns, A. J. (1993) Evidence for the de novo synthesis of fructan by enzymes from higher plants: a reappraisal of the SSF/FFT model, New Phytologist 123, 15–24.
- Canzi, E., Brighenti, F., Casiraghi, M., Del Puppo, E., Ferrari, A. (1995) Prolonged consumption of inulin in ready-to-eat breakfast: effect on intestinal ecosystem, bowel habits and lipid metabolism, COST '92 Workshop on Dietary Fibre and Fermentation, Helsinki, Finland.
- Castiglia-Delavaud, C., Verdier, E., Besle, J. M., Vernet, J., Boirie, Y., Beaufrere, B., De Baynast, R., Vermorel, M. (1998) Net energy value of non-starch polysaccharide isolates (sugarbeet fibre and commercial inulin) and their impact on nutrient digestive utilization in healthy human subjects, Br. J. Nutr. 80, 343–352.
- Causey, J. L., Feirtag, J. M., Gallaher, D. D., Tungland, B. C., Slavin, J. L. (2000) Effects of dietary inulin on serum lipids, blood glucose and the gastrointestinal environment in hypercholesterolemic men, Nutr. Res. 2, 191–201.
-
Chatteron, N. J.,
Harrison, P. A.,
Thornley, W. R.,
Bennet, J. H.
(1993)
Separation and quantification of fructan (inulin) oligomers by anion exchange chromatography, in: Inulin and Inulin-containing Crops ( A. Fuchs, Ed.), Amsterdam: Elsevier Science Publishers, vol. 3,
93–99.
10.1016/B978-0-444-89369-7.50018-X Google Scholar
- Ciucanu, I., Kerek, F. (1984) A simple and rapid method for the permethylation of carbohydrates, Carbohydr. Res. 131, 209–217.
- Claessens, G., Van Laere, A., De Proft, M. (1990) Purification and properties of an inulinase from chicory roots, J. Plant Physiol. 136, 35–39.
- Coudray, C., Bellanger, J., Castiglia-Delavaud, C., Rémésy, C., Vermorel, M., Rayssignuier, Y. (1997) Effects of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men, Eur. J. Clin. Nutr. 51, 375–380.
- Davidson, M., Maki, K., Synecki, C., Torri, S. A., Drennan, K. B. (1998) Effects of dietary inulin on serum lipids in men and women with hypercholesterolemia, Nutr. Res. 18, 503–517.
-
De Leenheer, L.
(1996)
Production and use of inulin: industrial reality with a promising future, in: Carbohydrates as Organic Raw Materials III ( H. Van Bekkum, H. Röper, F. Voragen, Eds.), New York: VCH,
67–92.
10.1002/9783527614899.ch4 Google Scholar
- De Leenheer, L., Hoebregs, H. (1994) Progress in the elucidation of the composition of chicory inulin, Starch 46, 193–196.
- De Roover, J., Van Laere, A., De Winter, M., Timmermans, J., Van den Ende, W. (1999) Purification and properties of a second fructan exohydrolose from the roots of Cichorium intybus, Physiol. Planta 106, 28–34.
- De Roover, J., Vandenbranden, K., Van Laere, A., Van den Ende, W. (2000) Drought induces fructan synthesis and 1 SST in roots and leaves of chicory seedlings, Planta 210, 808–814.
- De Soete, J., Booten, K., Daenekindt, L. (1998) Low density fructan composition, Patent Application WO 98 38223.
- Delzenne, N., Kok, N. (1998) Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism, Biochem. Soc. Trans. 26, 228–230.
- Delzenne, N., Kok, N., Fiordaliso, M. F., Deboyser, D. M., Goethals, F. M., Roberfroid, M. R. (1993) Dietary fructo-oligosaccharides modify lipid metabolism in rats, Am. J. Clin. Nutr. 57, 820S.
- Delzenne, N., Aertssens, J., Verplaetse, N., Roccaro, M., Roberfroid, M. (1995) Effect of fermentable fructo-oligosaccharides on energy and nutrients absorption in the rat, Life Sci. 57, 1579–1587.
- Den Hond, E., Geypens, B., Ghoos, Y. (2000) Effect of high performance chicory inulin on constipation, Nutr. Res. 20, 731–736.
- Edelman, J., Jefford, T. G. (1968) The mechanism of fructan metabolism in higher plants as exemplified in Helianthus tuberosus L, New Phytologist 123, 15–24.
- Ellegård, L., Andersson, H., Bosaeus, I. (1997) Inulin and oligofructose do not influence the absorption of cholesterol, and the excretion of cholesterol, Fe, Ca, Mg, and bile acids but increase energy excretion in man. A blinded, controlled cross-over study in ileostomy subjects, Eur. J. Clin. Nutr. 51, 1–5.
- Favier, C., Neut, C., Mizon, A., Cortot, A., Colombel, J.-F., Mizon, J. (1997) Fecal β-D-galactosidase production and Bifidobacteria are decreased in Crohn's disease, Dig. Dis. Sci. 42, 817–822.
- Fiordaliso, M., Kok, N., Desager, J. P., Goethals, F., Deboyser, D., Roberfroid, M., Delzenne, N. (1995) Dietary oligofructose lowers triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats, Lipids 30, 163–167.
- Franck, A. (1993) Rafticreming: the new process allowing to turn fat into dietary fibre in: FIE 1992 Conference Proceedings. Maarssen: Expoconsult Publishers, 193–197.
- Franck, A. (1998) Prebiotics stimulate calcium absorption: a review, Milchwissenschaft 53, 427–429.
- Franck, A., Coussement, P. (1997) Multi-functional inulin, Food Ingredients and Analysis International, October, 8–10.
-
French, A. D.
(1993)
Recent Advances in the structural chemistry of inulin, in: Inulin and Inulin-containing Crops, Studies in Plant Science ( A Fuchs, Ed.), Amsterdam: Elsevier Science Publishers, Vol. 3,
121–127.
10.1016/B978-0-444-89369-7.50022-1 Google Scholar
- Frippiat, A. (1994) Stabilized food composition, Patent Application WO 94 22327.
- Frippiat, A. (1998) Inulin based hydrocolloid compositions, Patent Application EP 867 470.
- Frippiat, A., Smits, G. (1993) Compositions having a creamy structure and containing fructan, preparation method therefor and uses thereof, Patent Application WO 93 06744.
- Gibson, G. R., Roberfroid, M. B. (1995) Dietary modulation of the human colonic microbiota – Introducing the concept of prebiotics, J. Nutr. 125, 1401–1412.
- Gibson, G. R., Wang, X. (1994) Bifidogenic properties of different types of fructo-oligosaccharides, Food Microbiol. 11, 491–498.
- Gibson, G. R., Beatty, E. R., Wang, X., Cummings, J. H. (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin, Gastroenterology 108, 975–982.
- Gleiss, A., Schneider, H. (1994) Preparation of long chain inulin and fructose and glucose by enzymatic treatment of crude inulin with a hydrolase, Patent Application DE 4316425.
- Harada, T., Suzuki, S., Toniguchi, H., Sasaki, T. (1993) Characteristics and applications of polyfructan synthesized from sucrase by Aspergillus sydowi conidia, Food Hydrocoll. 7, 23–38.
- Hata, H., Nakajima, K. (1984) Fructo-oligosaccharides intake and effect on the digestive tract, Proceedings of the 2nd Neosugar Research Conference, Tokyo, Japan.
- Hellwege, E., Gitscher, D., Wilmitzer, L., Heyer, A.G. (1997) Transgenic potato tubers accumulate high levels of 1-kestox and nystose, Plant J. 12, 1057–1065.
- Hellwege, E., Gritscher, D., Willmitzer, L., Heyer, A. (1998) Functional characterization of fructosyltransferase genes from Artichoke and Jerusalem Artichoke, in: Proceedings of the Seventh Seminar of Inulin (Fuchs, A., Van Laere, A., Eds.), European Fructan Association, 121–125.
- Hendry, G. A., Wallace, R. K. (1993) The origin, distribution and evolutionary significance of fructans, in: Science and Technology of Fructans ( M. Suzuki, N. J. Chatteron, Eds.), Boca Raton, FL: CRC Press, 119–139.
- Heyer, A. G., Wendenburg, R. (1997) Modified fructosyltransferase gene encoding protein with inulin-sucrase activity, Streptococcus mutans chimeric enzyme expression in a maize, rice, wheat, barley, sugarbeet, sugarcane or potato transgenic plant, for inulin production, Patent Application DE 19617687.
- Heyer, A. G., Hellwege, E. M., Willmitzer, L., Czapla, S., Sittlinger, B. (1999) Confirmation of the SST/FFT model of inulin synthesis by transgene expression in potato, in: Proceedings of the Eight Seminar on Inulin (Fuchs, A., Ed.), European Fructan Association, 94–101.
- Hidaka, H., Hirayama, M., Yamada, K. (1991) Fructo-oligosaccharides, enzymatic preparation and biofunctions, J. Carbohydr. Chem. 10, 509–516.
- Hincha, D. K., Hellwege, E. M., Heyer, A. G., Crowe, J. H. (2000) Plant fructans stabilize phosphatidylcholine liposomes during freeze-drying, Eur. J. Biochem. 267, 535–540.
- Hirayama, M., Hidaka, H. (1993) Production and utilization of microbial fructans, in: Science and Technology of Fructans ( M. Suzuki, N. J. Chatteron, Eds.), Boca Raton, FL: CRC Press, 273–302.
- Hoebregs, H. (1997) Fructans in foods and food products, ion-exchange chromatographic method: collaborative study, J. AOAC 5, 80, 1029–1037.
- Hosoya, N., Dhorranintra, B., Hidaka, H. (1988) Utilisation of U-14C fructo-oligosaccharides in man as energy resources, J. Clin. Biochem. Nutr. 5, 67–74.
- Ingelbert, G. (1999) Inutec, ein alternatives Bindmittel in sprügetrockneten Granulaten für die keramische Industrie, Keramische Zeitschrift 51, 3.
- Institut Genbiologische Forschung (1994) Polyfructan-sucrase DNA sequence from Erwinia amylovora expression in transgenic plant for polyfructan production, Patent Application DE4227061.
- Jackson, K. G., Taylor, G. R. J., Clohessy, A. M., Williams, C. M. (1999) The effect of the daily intake of inulin on fasting lipid, insulin and glucose concentrations in middle-aged men and women, Br. J. Nutr. 82, 23–30.
- Joye, D., Hoebregs, H. (2000) Determination of oligofructose, a soluble dietary fiber, by high-temperature capillary gas chromatography, J. AOAC International 83, 1020–1025.
- Jun, J. G., Gray, G. R. (1987) A new catalyst for reductive cleavage of methylated glycans, Carbohydr. Res. 163, 247–261.
- Kim, W., Won Choi, J., Won Yun, J. (1998) Selective production of GF4-fructooligosaccharide from sucrase by a new transfructosylating enzyme, Biotechnol. Lett. 20, 1031–1034.
- Kleessen, B., Sykura, B., Zunft, H. J. (1997) Effect of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons, Am. J. Clin. Nutr. 65, 1397–1402.
- Knudsen, K. E. B., Hessov, I. (1995) Recovery of inulin from Jerusalem artichoke (Helianthus tubersosus L.) in the small intestine of man, Br. J. Nutr. 74, 101–113.
- Kok, N., Roberfroid, M., Delzenne, N. (1996a) Dietary oligofructose modifies the impact of fructose on hepatic triacylglycerol metabolism, Metabolism 45, 1547–1550.
- Kok, N., Roberfroid, M., Robert, A., Delzenne, N. (1996b) Involvement of lipogenesis in the lower VLDL secretion induced by oligofructose in rats, Br. J. Nutr. 76, 881–890.
- Kok, N., Morgan, L., Williams, C., Roberfroid, M., Thissen, J. P., Delzenne, N. (1998a) Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats, J. Nutr. 128, 1099–1103.
-
Kok, N.,
Taper, H. S.,
Delzenne, N. M.
(1998b)
Oligofructose modulates lipid metabolism alterations induced by a fat-rich diet in rats,
J. Appl. Toxicol. 18,
47–53.
10.1002/(SICI)1099-1263(199801/02)18:1<47::AID-JAT474>3.0.CO;2-S CAS PubMed Web of Science® Google Scholar
- Koops, A. J., Jonker, H. H. (1996) Purification and characterisation of the enzymes of fructan biosynthesis in tubers of Helianthus tuberosus, Plant Physiol. 110, 1167–1175.
- Koops, A., Sevenier, R., Van Tunen, A., De Leenheer, L. (1999) Patent WO 99/54480 Applicant: “Stichting Dienst Landbouwkundig Onderzoek” and Tiense Suikerraffinaderij.
- Koops, A., Van Arkel, J., Hakkert, H., Vorst, O. (2000) DNA chips: useful tool to analyze fructan metabolism in chicory tap roots, Fourth International Fructan Symposium, Abstract 3.2
- Kruse, H. P., Kleessen, B., Blaut, M. (1999) Effects of inulin on faecal bifidobacteria in human subjects, Br. J. Nutr. 82, 375–382.
- Kulz, E. (1874) Beitrage zur Path. Therap. der Diabetes, Jahrb. Tierchem. 4, 448.
- Kunz, M., Haji Begli, A. (1995) Inulinderivate, Verfahren zu deren Herstellung sowie ihre Verwendung, Patent Application EP 638 589.
- Kunz, M., Munir, M., Vogel, M. (1994) Verfahren zur Herstellung von langkettigern Inulin, Patent Application EP 627 490.
- Kuppers-Sonnenberg, G. A. (1971) Topinambur in der Diabetiker-Diät, Selecta 37, 2836–2840.
- Lemort, C., Roberfroid, M. (1997) Effect of chicory fructo-oligosaccharides on Ca balance, Abstracts of NDO symposium, Wageningen, 163.
- Leroux, X. (1996) La vie c'est bon comme tout, Commercial Publication, 5.
- Levrat, M.-A., Favier, M.-L., Moundras, C., Rémésy, C., Demigné, C., Morand, C. (1994) Role of dietary propionic acid and bile acid excretion in the hypocholesterolemic effects of oligosaccharides in rats, J. Nutr. 124, 531–538.
- Lewis, D. H. (1991) Fungi and sugars – a suite of interactions, Mycol. Res. 95, 897.
- Lewis, H. B. (1912) The value of inulin as a foodstuff, J. Am. Med. Assoc. 58, 176–177.
- Maruzen, Kazei (1991) New cyclic inulo-oligosaccharide preparation form inulin or fructose using enzyme or microorganism, e.g. Bacillus circulans, Patent Application J02252701.
- McCance, R. A., Lawrence, R. D. (1929) The carbohydrate content of foods – inulin and the fructosans, Medical Research Council, Special Report Series 135, 58.
- McCleary, B., Murphy, A., Mugford, D. (2000) Measurement of total fructan in foods by enzymatic/spectrophotometric method: collaborative study, J. AOAC 83, 356–364.
- Merrigi, A., Stevens, C. V., Booten, K. (2001) Chemical modification of inulin, a valuable remarkable resource, and its industrial applications, accepted for publication.
- Meyer, W. J. M., Matthysen, E. W. J. M., Borm, G. E. L. (1993) Crop characteristics and inulin production of Jerusalem Artichoke and Chicory, in: Inulin and Inulin-containing Crops, Studies in Plant Science ( A Fuchs, Ed.), Amsterdam: Elsevier Science Publishers, Vol. 3, 29–44.
- Mischnick-Lübbecke, P., König, W. A. (1989) Determination of the substitution pattern of modified polysaccharides. Part I. Benzyl starches, Carbohydr. Res. 185, 113–118.
- Mitsubishi Chemicals (1991) Difructose dianhydride-I production from inulin using inulinase from Arthrobacter sp., Patent Application J03247295.
- Mitsui Toatsu Chemicals (1991) Production of inulo-oligosaccharide, inulin decomposition using Penicillium purpurogenum var. rubri-sclerotium and Aspergillus ficuum inulinase, Patent Application EP429077.
- Nakamura, T., Maruki, S., Nakatsu, S., Veda, S. (1978) General properties of an extracellular inulinase from Aspergillus sp., Nippon Nogei Kagaku Kaishi 52, 581–587.
- Netherlands Science Research Foundation (1994) Method for transgenic plant construction with modified fructan content potato transformation with plant, Bacillus subtilis or Streptococcus mutans tolerance, Patent Application WO 94 14970.
- Norinsho, Nihon Denpun Kogyokk (1989) Di-fructose di-anhydride, obtained by heating inulin (plant extract) with inulin fructo-transferase fixed on solid support of chitosan and silica, Japanese Patent JO1285195.
- Onodera, S., Shiomi, N. C. (1988) Purification and substrate specificity of endo-type inulinase from Penicillium purpurogenum, Agric. Biol. Chem. 52, 2569–2575.
- ORAFTI (2001) Golden rules for success in chicory, Vademecum for the farmer ( , Ed.).
- Partida, V. Z., Lopez, A. C., Gomez, A. J. M. (1997) Fructose syrup production from agave plant pulp by extraction and inulinase treatment, Patent Application WO 97 34017.
- Persia (1905) Reference of Lewis (1912), Nuova Revista Clin. Therapeut, 8.
-
Ponstein, A. S.,
Van Leeuwen, M. B.
(1993)
In vitro synthesis of inulin by the inulosucrase from Streptococcus mutans, in: Inulin and Inulin containing crops, Studies in Plant Science ( A. Fuchs, Ed.), Amsterdam: Elsevier Science Publishers, Vol. 3,
281–287.
10.1016/B978-0-444-89369-7.50043-9 Google Scholar
- Prosky, L. (1999) Inulin and oligofructose are part of the dietary fiber complex, J. AOAC Int. 82, 223–226.
- Reddy, D. S., Hamid, R., Rao, C. V. (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition, Carcinogenesis 18, 1371–1374.
- Roberfroid, M. (1993) Dietary fiber, inulin and oligofructose: a review comparing their physiological effects, Crit. Rev. Food Sci. Nutr. 33, 103–148.
- Roberfroid, M. B. (1997) Health benefits of non-digestible oligosaccharides, in: Dietary Fiber in Health and Disease ( D. Kritchevsky, C. Bonefield, Eds.), New York: Plenum Press, 211–219.
- Roberfroid, M., Gibson, G. R., Delzenne, N. (1993) Biochemistry of oligofructose, a non-digestible fructooligosaccharide: an approach to estimate its caloric value, Nutr. Rev. 51, 137–146.
- Roberfroid, M., Van Loo, J., Delzenne, N., Coussement, P. (1996) Use of a composition containing inulin or oligofructose in cancer treatment, Patent Application EP 692 252.
- Roberfroid, M., Van Loo, J., Gibson, G. (1998) The bifidogenic nature of chicory inulin and its hydrolysis products, J. Nutr. 128, 11–19.
- Roland, N., Nugon-Baudon, L., Szylit, O. (1994a) Influence of dietary fibres on two intestinal transferases in rats inoculated with a whole human faecal flora, R. Soc. Chem. 123, 369–373.
- Roland, N., Nugon-Baudon, L, Flinois, J. P., Beaune, Ph. (1994b) Hepatic and intestinal cytochrome P450, glutathione-S-transferase and UDP-glucuronyltransferase are affected by six types of dietary fibre in rats inoculated with a human whole faecal flora, J. Nutr. 124, 1581–1587.
- Roland, N., Nugon-Baudon, L., Andrieux, C., Szylit, O. (1995) Comparative study of the fermentative characteristics of inulin and different types of fiber in rats inoculated with a human whole fecal flora, Br. J. Nutr. 74, 239–249.
- Roland, N., Rabot, S., Nugon-Baudon, L. (1996) Modulation of the biogenical effects of glucosinolates by inulin and oat fibre in gnotobiotic rats inoculated with a whole human flora, Food Chem. Toxicol. 34, 671–677.
- Root, H., Baker, M. (1925) Inulin and artichokes in the treatment of diabetes, Arch. Intern. Med. 36, 126–145.
- Rose, V. (1804) Über eine eigenthumliche vegetablische Substanz, Gehlens Neues Algem. Jahrb. Chem. 3, 217.
- Rowland, I. R., Rummey, C. J., Coutts, J. T., Lievense, L. (1998) Effects of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats, Carcinogenesis 19, 281–285.
- Sachs, J. (1864) Über die Sphärokristalle des Inulins und dessen mikroskopische Nachweisung in den Zellen, Bot. Z. 22, 77.
- Scholz-Ahrens, K., Van Loo, J., Schrezenmeir, J. (1998) Oligofructose stimuliert die Femurmineralisation in Abhängigkeit von der Calciumzufuhr bei der ovariektomisierten Ratte, Symposium Deutsche Gesellschaft für Ernährungsforschung, Karlsruhe.
- Sevenier, R., Hall, R. D., Van der Meer, I. M., Hakkert, H. J., Van Tunen, A. J., Koops, A. J. (1998) High level fructan accumulation in transgenic sugar beet, Nature Biotechnol. 16, 843–846.
- Shannon, J. A., Smith, H. W. (1935) The excretion of inulin, xylose and urea by normal and man, J. Clin. Invest. 14, 393–401.
- Sherianne, M. (1998) Method for producing fat-free and low-fat viscous dressings using inulin, Patent Application US 5, 721, 004.
- Smeekens, J. C. M., Ebskamp, M. J., Geerts, H. A. M., Weisbeek, P. J. (1996) Production of oligosaccharides by transgenic plants by Streptococcus mutans, Bacillus subtilis, onion, barley or sunflower fructosyltransferase gene transfer, Patent Application WO 96 01904.
- Smits, G., Daenekindt, L., Booten, K. (1994) Fractionated polydisperse compositions, Patent Application WO 96 01849.
- Smits, G., Daenekindt, L., Booten, K. (1994) Pelletized composition, preparation method therefor and food products containing same, Patent Application WO 94 19973.
- Smits, G., Daenekindt, L., Booten, K. (1997) Fractionated polydisperse composition, Patent Application EPO 679026B1.
- Stevens, C., Booten, K., Laquiere, I., Daenekindt, L. (1999) Surface-active alkylurethanes of fructans, Patent Application WO 99 64549.
- Strauss, H. (1911) Zur verwendung inulinreicher Gemüse bei Diabetikern, Therapie der Gegenwart III, 347–351.
- Tamura, K., Kuramoto, T., Kitahata, S. (1988) Enzymatic manufacture of di-D-fructosylfuranose 1,2; 2,3-dianhydride, Japanese Patent 63219389.
- Taper, H. S., Delzenne, N., Tshilombo, A., Roberfroid, M. (1995) , Dietary fructo-oligosaccharides (FOS) protect young rats against the atrophy of exocrine pancreas induced by high fructose and partial copper deficiency, Food Chem. Toxicol. 33, 631–639.
-
Taper, H.,
Delzenne, N.,
Roberfroid, M. B.
(1997)
Growth inhibition of transplantable mouse tumours by non digestible carbohydrates,
Int. J. Cancer 71,
1109–1112.
10.1002/(SICI)1097-0215(19970611)71:6<1109::AID-IJC30>3.0.CO;2-5 CAS PubMed Web of Science® Google Scholar
- Taper, H., Lemort, C., Roberfroid, M. (1998) Inhibition effect of dietary inulin and oligofructose on the growth of transplantable mouse tumor, Anticancer Res. 18, 4123–4126.
- Taper, H., Frippiat, A, Van Loo, J., Roberfroid, M. (1999) Synergistic composition for use in the treatment of cancer, Patent Application WO 99 59600.
- Thomson, T. (1818) A System of Chemistry, 5th London edition, Abraham Small, Philadelphia, 4, 65.
- Timmermans, J. W., van Leeuwen, M. B., Tournois, H., de Wit, D., Vliegenthart, J. F. G. (1993) Proceedings of the fourth seminar on inulin, Wageningen, 12–15.
- Timmermans, J. W., Bitter, M. G., de Wit, D., Vliegenthart, J. F. G. (1997) The interaction of inulin oligosaccharides with Ba2+ studied by 1H-NMR spectroscopy, J. Carbohydr. Chem. 2, 213–230.
- Trautwein, E. A., Rieckhoff, D., Erbersdobler, H. F. (1998) Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters, J. Nutr. 128, 1937–1943.
- Turk, S., Gerrits, N., Smeekens, J. C. M., Weisbeek, P. J. (1997) Production of modified polysaccharides by treatment with sugar donor and transfer enzyme, starch production by treatment with enzyme or by expression in transgenic plant expressing fructosyltransferase or in a suspension cell culture prepared from the transgenic plant, Patent Application WO 97 29186.
- Uchiyama, T. (1993) Metabolism in microorganism, Part II: Biosynthesis and degradation of fructans by microbial enzymes other than levansucrase, in: Science and Technology of Fructans ( M. Suzuki, N. J. Chatteron, Eds.), Boca Raton, FL: CRC Press, 169–190.
- Vandamme, E. J., De Rijcke, D. (1983) Microbial inulinases: fermentation processes, properties and applications, Adv. Appl. Microbiol. 29, 139–176.
- Van den Ende, W. (1996) Fructan metabolism in chicory roots (Cichoriumintybus L.), PhD Thesis, University of Leuven (B), 11.
- Van den Ende, W., De Roover, J., Van Laere, A. (1996) In vitro synthesis of fructo-oligosaccharide from inulin and fructose by purified chicory root FFT, Physiol. Plant 97, 346–352.
- Van den Ende, W., Michiels, A., Van Wonterghem, D., Vergauwen, R., Van Laere, A. (2000a) Cloning developmental and tissue-specific expression of sucrose:sucrose 1-Fructosyltransferase from Taraxacum officinale. Fructan localisation in roots, Plant Physiol. 123, 71–79.
- Van den Ende, W., Michiels, A., De Roover, J., Verhaert, P., Van Laere, A. (2000b) Cloning and functional analysis of chicory root fructan 1-exohydrolase I: a vacuolar enzyme derived from a cell-wall invertase ancestor? Plant J. 24, 447–456.
- Van den Heuvel, E., Muys, T., Van Dokkum, W., Schaafsma, G. (1999) Oligofructose stimulates calcium absorption in adolescents, Am. J. Clin. Nutr. 69, 544–548.
- Van Geel-Schutten, I. (2000) Expolysaccharide synthesis by Lactobacillus reuteri, molecular characterisation of a fructosyltransferase and a glucansucrase, PhD Thesis, University of Groningen, The Netherlands, 53–73.
- Van Lengerich, B., Larson, M. (1999) Cereal products with inulin and methods of preparation, Patent Application WO 99 346 88.
- Van Loo, J., Booten, K., Smits, G. (1994) Method for separating a polydispersed saccharide composition, resulting products and use thereof in food compositions, Patent Application WO 94 12541.
- Van Loo, J., Coussement, P., De Leenheer, L., Hoebregs, H., Smits, G. (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet, Crit. Rev. Food Sci. Nutr. 35, 525–552.
- Van Loo, J., Cummings, J., Delzenne, N., Englyst, H., Franck, A., Hopkins, M., Kok, N., Macfarlane, G., Newton, D., Quigley, M., Roberfroid, M., van Vliet, T., van den Heuvel, E. (1999) Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project (DGXII AIRII-CT94-1095), Br. J. Nutr. 81, 121–132.
- Van Tunen, A. J., Van der Meer, I. M., Koops, A. J. (1996) DNA sequences encoding fructan-producing enzymes, Jerusalem artichoke-derived fructosyltransferase expression in transgenic plant for low calorie sweetener production, Patent Application WO 96 21023.
- Verraest, D., Batelaan, J., Peters, J., Van Bekkum, H. (1995a) Carboxymethyl inulin, Patent Application WO 95 15984.
- Verraest, D. L., Peters, J. A., Batelaan, J. G., van Bekkum, H. (1995b) Carboxymethylation of inulin, Carbohydr. Res. 271, 101–112.
- Verraest, D. L., Peters, J. A., van Bekkum, H., van Rosmalen, G. M. (1996) Carboxymethyl inulin: a new inhibitor for calcium carbonate precipitation, J. Am. Oil Chem. Soc. 73, 55–62.
- Vijn, I., Van Dijken, A., Lüscher, M., Bos, A., Smeets, E., Weisbeek, P., Wiemken, A., Smeerkens, S. (1998) Cloning of sucrose: sucrose 1-fructosyltransferase from onion and synthesis of structurally defined fructan molecules from sucrose, Plant Physiol. 117, 1507–1513.
- Von Mehring, P. (1876) Referenced by Lewis (1912).
- Wang, X., Gibson, G. R. (1993) Effects of the in vitro fermentation of oligofructose and inulin by bacteria growing in the human large intestine, J. Appl. Bacteriol. 75, 373–380.
- Watherhouse, A. L., Chatterton, N. J. (1993) Glossary of fructan terms, in: Science and Technology of Fructans ( M. Suzuki, N. J. Chatteron, Eds.), Boca Raton, FL: CRC Press, 2–7.
- Wiedmann, M., Jager, M. (1997) Synergistic sweeteners, Food Ingredients and Analysis International, November–December, 51–56.
- Wise, E., Heyl, F. (1931) Failure of a diabetic to utilize inulin, J. Am. Pharm. Soc. 20, 26–29.
- Xiao, R., Tanida, M., Takao, S. (1989) Purification and some properties of endo-inulinase from Chrysosporium pannorum, J. Ferment. Bioeng. 67, 244–251.
- Yanai, K., Nakane, A., Nakumara, H., Baba, Y., Watabe, A., Hirayama, M. (1997) Recombinant beta-fructofuranosidase from gene derived from Aspergillus niger and enzyme engineering for use in fructooligosaccharide production from sucrose, Patent Application WO 97 34004.
- Zittan, L. (1981) Enzymatic hydrolysis of inulin, an alternative way to fructose production, 32° Starch convention, Detmold, Germany.
-
Zubr, J.,
Pedersen, H.S.
(1993)
Characteristics of growth and development of different Jerusalem Artichoke cultivars, in: Inulin and Inulin-containing Crops, Studies in Plant Science ( A. Fuchs, Ed.), Amsterdam: Elsevier Science Publishers, Vol. 3,
11–19.
10.1016/B978-0-444-89369-7.50008-7 Google Scholar
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