Alginates from Bacteria

Part 5. Polysaccharides
Dr. Bernd H. A. Rehm

Dr. Bernd H. A. Rehm

Westfälische Wilhelms-Universität Münster, Institut für Mikrobiologie, Corrensstraβe 3, Münster, Germany, 48149

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First published: 15 January 2005
Citations: 6

Abstract

  • Introduction
  • Historical Outline
  • Chemical Structures
  • Biosynthetic Pathway of the Alginate Precursor, GDP-Mannuronic Acid
  • Genetics of Alginate Biosynthesis
  • Regulation of Alginate Biosynthesis
    • Environmentally Induced Activation of alg Genes
    • Genotypic Switch
  • Polymerization and Export of the Alginate Chain
  • Alginate-Modifying Enzymes
    • Mannuronan C-5-epimerases
      • Functional Differences
      • The Biotechnological Potential
    • O-Transacetylases
    • Alginate Lyases
      • Reaction Mechanism
      • Function in Alginate-Producing Bacteria
      • Structure–Function Analysis
      • Substrate-Binding and Catalytic Sites
      • Future Applications
  • The Role of Alginate in Biofilm Formation
  • The Applied Potential of Bacterial Alginates
  • Acknowledgments

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