Full Paper

Corrections for off-resonance effects and incomplete saturation in conventional (two-site) saturation-transfer kinetic measurements

Corresponding Author

Peter B. Kingsley

[email protected]

Department of Radiology, North Shore University Hospital, Manhasset, New York

Department of Radiology, New York University Medical College, New York, New York

Department of Radiology/MRI, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030===Search for more papers by this author

W. Gordon Monahan,

W. Gordon Monahan

Department of Radiology, North Shore University Hospital, Manhasset, New York

Department of Radiology, New York University Medical College, New York, New York

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Peter B. Kingsley,

Corresponding Author

Peter B. Kingsley

[email protected]

Department of Radiology, North Shore University Hospital, Manhasset, New York

Department of Radiology, New York University Medical College, New York, New York

Department of Radiology/MRI, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030===Search for more papers by this author

W. Gordon Monahan,

W. Gordon Monahan

Department of Radiology, North Shore University Hospital, Manhasset, New York

Department of Radiology, New York University Medical College, New York, New York

Search for more papers by this author

First published: 07 June 2000

https://doi.org/10.1002/1522-2594(200006)43:6<810::AID-MRM6>3.0.CO;2-J

Citations: 29

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Abstract

The effects of off-resonance irradiation and incomplete saturation on saturation-transfer measurements of chemical-exchange rates are discussed. With off-resonance effects there is no exact formula for the exchange rate constant from spin D to spin E, k_DE, in terms of observable signal intensities and relaxation rates. However, k_DE can be estimated by measuring the effective spin-lattice relaxation rate constant of spin D when spin E is saturated, *R₁, plus signal intensities with no RF irradiation, M_0D and M_0E; with irradiation of a control position, M′_D and M′_E; and with saturation of spin E, *M_D and *M_E. Several formulas are compared and the best formula for calculating k_DE appears to be either k_DE = *R₁ [(M′_D− *M_D)/M_0D]/[(M′_E − *M_E)/M_0E], or the same formula with M_0D and M_0E replaced by M′_D and M′_E. These formulas are exact with incomplete saturation and no off-resonance effects, and are better than previously published formulas when off-resonance effects are present. More accurate formulas are available if signal intensities and relaxation rates can be measured while the exchange process is stopped. Magn Reson Med 43:810–819, 2000. © 2000 Wiley-Liss, Inc.

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Volume43, Issue6

June 2000

Pages 810-819

Corrections for off-resonance effects and incomplete saturation in conventional (two-site) saturation-transfer kinetic measurements

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Corrections for off-resonance effects and incomplete saturation in conventional (two-site) saturation-transfer kinetic measurements

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