Volume 41, Issue 13 pp. 2265-2269
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Small Interfering RNAs and Their Chemical Synthesis

Ronald Micura Dr.

Ronald Micura Dr.

Leopold Franzens University Institute of Organic Chemistry Innrain 52a, 6020 Innsbruck (Austria) Fax: (+43) 512-5072892

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Abstract

Improved protecting-group strategies are used in two successful methods for the synthesis of oligoribonucleotides. The effective production of these compounds is of growing importance in the context of RNA interference, a phenomenon that is exploited for investigations into protein function.

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