Dynamics of Hole Trapping by G, GG, and GGG in DNA
William B. Davis Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorIzabela Naydenova Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorReinhard Haselsberger Dipl.-Phys.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorAlexander Ogrodnik Priv.-Doz. Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorBernd Giese Prof. Dr.
Institut für Organische Chemie der Universität St.-Johanns-Ring 19, 4056 Basel (Switzerland) Fax: (+41) 61-2671105
Search for more papers by this authorMaria E. Michel-Beyerle Prof. Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorWilliam B. Davis Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorIzabela Naydenova Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorReinhard Haselsberger Dipl.-Phys.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorAlexander Ogrodnik Priv.-Doz. Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorBernd Giese Prof. Dr.
Institut für Organische Chemie der Universität St.-Johanns-Ring 19, 4056 Basel (Switzerland) Fax: (+41) 61-2671105
Search for more papers by this authorMaria E. Michel-Beyerle Prof. Dr.
Institut für Physikalische und Theoretische Chemie Technische Universität München Lichtenbergstrasse 4, 85748 Garching (Germany) Fax: (+49) 89-289-13026
Search for more papers by this authorWe thank Joshua Jortner, Notker Rösch, and Alexander Voityuk for stimulating discussions and critical reading of the manuscript. W.B.D. greatly appreciates a postdoc fellowship from the Alexander von Humboldt Foundation. Financial support from the Volkswagenstiftung is gratefully acknowledged.
Abstract
Hole transfer from an excited, DNA-intercalated injector (1), to either G or to the “traps” GG or GGG occurs with similar rates, and always results in oxidation of the proximate guanine residue. These results indicate that charge trapping in GG or GGG must occur by a relaxation mechanism (structural and/or energetic) which is inherent in these sequences in DNA duplexes.
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