Volume 39, Issue 20 pp. 3638-3641
Communication

The First Dendrimer-Based Enantioselective Fluorescent Sensor for the Recognition of Chiral Amino Alcohols

Vincent J. Pugh Dr.

Vincent J. Pugh Dr.

Department of Chemistry University of Virginia Charlottesville, VA 22901

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Qiao-Sheng Hu Dr.

Qiao-Sheng Hu Dr.

Department of Chemistry University of Virginia Charlottesville, VA 22901

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Lin Pu Prof. Dr.

Lin Pu Prof. Dr.

Department of Chemistry University of Virginia Charlottesville, VA 22901

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The support of this work by the National Institute of Health (1R01GM58454) is gratefully acknowledged. We also thank the partial support from the donors of the Petroleum Research Fund—administered by the American Chemical Society.

Abstract

Enhanced fluorescence as well as more sensitive fluorescence responses towards chiral quenchers are observed for dendrimer 1 (R=tBu) than its chiral core binaphthol unit. The fluorescence of the chiral dendrimer 1 is quenched efficiently and enantioselectively by chiral amino alcohols such as 2.

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