Toxicology, 3. Evaluation of Toxic Effects

Wolfgang Dekant

Wolfgang Dekant

Institute of Toxicology, University of Wuerzburg, Germany

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Spiridon Vamvakas

Spiridon Vamvakas

Institute of Toxicology, University of Wuerzburg, Germany

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First published: 15 October 2011

Abstract

The article contains sections titled:

1.

Acceptable risk, Comparison of Risks, and Establishing Acceptable Levels of Risk

2.

The Risk Assessment Process

2.1.

Hazard Identification Techniques

2.2.

Determination of Exposure

2.3.

Dose-Response Relationships

2.4.

Risk Characterization

2.4.1.

The Safety-Factor Methodology

2.4.2.

Risk Estimation Techniques for Nonthreshold Effects

2.4.3.

Mathematical Models Used in High- to Low-Dose Risk Extrapolation

2.4.4.

Interpretation of Data from Chronic Animal Bioassays

2.4.5.

Problems and Uncertainties in Risk Assessment

3.

Future Contributions of Scientifically Based Procedures to Risk Assessment and Qualitative Risk Assessment for Carcinogens

4.

Risk Assessment for Teratogens

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