Vitamin, 6. Vitamin B1 (Thiamin)

Ulla Létinois

Ulla Létinois

DSM Nutritional Products, Basel, Switzerland

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Gerard Moine

Gerard Moine

F. Hoffmann-La Roche Ltd, Basel, Switzerland

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Hans-Peter Hohmann

Hans-Peter Hohmann

Loerrach, Germany

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Abstract

The article contains sections titled:

1 Structure and Nomenclature
2 History
3 Physical Properties
4 Chemical Properties
5 Natural Occurrence and Isolation
6 Biosynthesis in Microorganisms
6.1 Biosynthesis of the Pyrimidine Component in Prokaryotes
6.2 Biosynthesis of the Pyrimidine Component in Eukaryotes
6.3 Biosynthesis of the Thiazole Component
6.4 Biosynthesis of Thiamin Pyrophosphate
6.5 Thiamin Biosynthetic Genes from E. coli
6.6 Mapping and Cloning of Thiamin Biosynthetic Genes from Other Species
6.7 Regulation of Thiamin Biosynthesis in Prokaryotes and Eukaryotes
6.8 Thiamin-Overexpressing Microorganisms
7 Chemical Synthesis
7.1 Condensation of the Pyrimidine and Thiazole Rings
7.2 Construction of the Thiazole Ring on a Preformed Pyrimidine Portion
8 Commercial Forms
9 Derivatives, Analogues, and Antimetabolites
10 Biochemical and Physiological Functions
10.1 Metabolic Functions in the Organism
10.2 Thiamin Requirements and Deficiency
11 Analytical Methods
References

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