Genetic polymorphisms of XRCC1 and risk of the esophageal cancer
Corresponding Author
Jang-Ming Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Fax: +886-2-23930877
Department of Surgery, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYung-Chie Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorShi-Yi Yang
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorPei-Wen Yang
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorShi-Ping Luh
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChun-Jean Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChien-Jen Chen
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorMing-Tsang Wu
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taipei, Taiwan
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Search for more papers by this authorCorresponding Author
Jang-Ming Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Fax: +886-2-23930877
Department of Surgery, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan, Republic of ChinaSearch for more papers by this authorYung-Chie Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorShi-Yi Yang
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorPei-Wen Yang
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorShi-Ping Luh
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChun-Jean Lee
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
Search for more papers by this authorChien-Jen Chen
Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
Search for more papers by this authorMing-Tsang Wu
Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taipei, Taiwan
Occupational Health Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Search for more papers by this authorAbstract
A variety of environmental factors were identified to be associated with the risk of esophageal cancer. The variation in capacity of DNA repair might influence environmental chemical-associated carcinogenesis. We hypothesized that the polymorphic XRCC1 genes might modify cancer susceptibility of the esophagus. To investigate the effect of XRCC1 genetic polymorphisms on codons 194, 280 and 399, we evaluated data from 105 patients of esophageal squamous cell carcinoma and 264 healthy controls, matching with age (±3 years), gender and ethnicity. The distribution of the 3 genotypes were not significantly different among patients and controls. However, among alcohol drinkers, the XRCC1399 Arg/Arg genotype was more frequently found in patients with esophageal cancer. After adjustment with other environmental confounders, the OR for the genotype of XRCC1399 Arg/Arg was 2.78 (95% CI =1.15–6.67) as compared with the XRCC1399 Arg/Gln and XRCC1399 Gln/Gln genotypes in the alcohol drinkers. Similar trends were observed among cigarette smokers and areca chewers. However, they did not reach a statistical significance. Our findings suggest that the polymorphic XRCC1 genes might modify the risk of alcohol-associated esophageal cancers. © 2001 Wiley-Liss, Inc.
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