Clinicopathologic features and treatment of postirradiation sarcoma of bone and soft tissue
Yoshiya Z. Inoue MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorFrank J. Frassica MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorCorresponding Author
Franklin H. Sim MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Mayo Clinic, 200 First Street SW, Rochester, MN 55905Search for more papers by this authorK. Krishnan Unni MB, BS
Division of Anatomic Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorIvy A. Petersen MD
Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorRichard A. McLeod MD
Department of Diagnostic Radiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorYoshiya Z. Inoue MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorFrank J. Frassica MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorCorresponding Author
Franklin H. Sim MD
Department of Orthopedics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Mayo Clinic, 200 First Street SW, Rochester, MN 55905Search for more papers by this authorK. Krishnan Unni MB, BS
Division of Anatomic Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorIvy A. Petersen MD
Division of Radiation Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorRichard A. McLeod MD
Department of Diagnostic Radiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota
Search for more papers by this authorAbstract
Background and Objectives
An analysis of the clinicopathologic features and treatment of patients with postirradiation sarcoma of bone and soft tissue was performed to guide modern evaluation and management.
Methods
A retrospective analysis of 135 sarcomas in 130 patients was performed.
Results
The mean age of the 130 patients was 48 years, and there was a female predominance because of irradiation for carcinomas of the breast and uterus. Indication for irradiation was a soft tissue lesion (such as lymphoma or breast cancer) in 58.5% of patients and a bone lesion (such as giant cell tumor or fibrous dysplasia) in 41.5%. The latent period (interval between irradiation and discovery of the sarcoma) ranged from 4–55 years (mean, 17 years). Of the lesions, 74% were stage IIB (high-grade extra-compartmental) and 24% were stage III (metastases). Ninety-four patients received their treatment at our institution. Of the 61 patients with resectable disease, 49 had amputations and 12 had limb salvage procedures. The 5-year cumulative survival rate was 68.2% for patients with peripheral (extremities, including proximal femur and hip) resectable lesions and 27.3% for patients with central (pelvis, head/neck, and ribs) resectable lesions. The local recurrence rate correlated with the surgical margin achieved: intralesional, 73%, marginal, 64%, and wide, 23%.
Conclusions
The prognosis for patients with peripheral resectable postirradiation sarcomas is good if a wide surgical margin can be achieved. This group of patients should be treated aggressively because they have a new cancer. J. Surg. Oncol. 2000;75:42–50. © 2000 Wiley-Liss, Inc.
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