Treatment with cytotoxic immunosuppression agents increases urinary excretion of JCV in patients with autoimmune disease
Meilin Wang
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Search for more papers by this authorRong-Tai Tsai
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorWei-Chih Ou
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Search for more papers by this authorChih-Kuang Lin
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorGregory J. Tsay
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorHan Chang
Department of Pathology, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorCorresponding Author
Deching Chang
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, No. 110, Section 1, Chien Kou N. Road, Taichung 402, Taiwan, Republic of China===Search for more papers by this authorMeilin Wang
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Search for more papers by this authorRong-Tai Tsai
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorWei-Chih Ou
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Search for more papers by this authorChih-Kuang Lin
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorGregory J. Tsay
Department of Internal Medicine, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorHan Chang
Department of Pathology, Chung Shan Hospital, Taichung, Taiwan, Republic of China
Search for more papers by this authorCorresponding Author
Deching Chang
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China
Department of Microbiology and Immunology, Chung Shan Medical and Dental College, No. 110, Section 1, Chien Kou N. Road, Taichung 402, Taiwan, Republic of China===Search for more papers by this authorAbstract
Human JC virus is ubiquitous in human populations and is reactivated frequently in immunosuppressed patients. Fifty-one patients with autoimmune disease receiving immunomodulating therapy were evaluated to study the possible relationship between immunosuppression and JCV viruria. Patients were divided into cytotoxic and noncytotoxic treatment groups based on their prescription. The incidence of JCV viruria in the cytotoxic treatment group was significantly higher than that in the noncytotoxic group (67% vs. 28%; P < 0.05). Most patients with JCV viruria were receiving corticosteroid (P = 0.03 for any dose and P < 0.001 for higher-dose treatments) and cytotoxic agents (P = 0.02). Age, disease duration, and medication duration appeared not to be the precipitating factors of JCV viruria in this study. The results of clinical evaluation indicate that cytotoxic immunosuppression may play an important role in JC virus reactivation. J. Med. Virol. 62:505–510, 2000. © 2000 Wiley-Liss, Inc.
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