Factorial Designs in Clinical Trials

3

Steven Piantadosi, 

Steven Piantadosi

Johns Hopkins University, Baltimore, MD, USA

Search for more papers by this author

Steven Piantadosi, 

Steven Piantadosi

Johns Hopkins University, Baltimore, MD, USA

Search for more papers by this author

First published: 15 July 2005

https://doi.org/10.1002/0470011815.b2a01025

References

• 1 ACAPS Group (1992). Rationale and design for the Asymptomatic Carotid Artery Plaque Study (ACAPS), Controlled Clinical Trials 13, 293–314.
  10.1016/0197-2456(92)90012-O

  PubMed Google Scholar
• 2 Assaf, A. R. & Carleton, R. A. (1994). The Women's Health Initiative clinical trial and observational study: history and overview, Rhode Island Medicine 77, 424–427.
  CAS PubMed Google Scholar
• 3 ATBC Cancer Prevention Study Group (1994). The alpha-tocopherol beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance, Annals of Epidemiology 4, 1–9.
  10.1016/1047-2797(94)90036-1

  PubMed Google Scholar
• 4 ATBC Cancer Prevention Study Group (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers, New England Journal of Medicine 330, 1029–1034.
  10.1056/NEJM199404143301501

  PubMed Web of Science® Google Scholar
• 5 Berson, E. L., Rosner, B., Sandberg, M. A., Hayes, K. C., Nicholson, B. W., Weigel-DiFranco, C. & Willett, W. (1993). A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa, Archives of Ophthalmology 111, 761–772.
  10.1001/archopht.1993.01090060049022

  CAS PubMed Web of Science® Google Scholar
• 6 Byar, D. P. & Piantadosi, S. (1985). Factorial designs for randomized clinical trials, Cancer Treatment Reports 69, 1055–1063.
  CAS PubMed Web of Science® Google Scholar
• 7 Byar, D. P., Herzberg, A. M. & Tan, W.-Y. (1993). Incomplete factorial designs for randomized clinical trials, Statistics in Medicine 12, 1629–1641.
  10.1002/sim.4780121708

  CAS PubMed Web of Science® Google Scholar
• 8 Cox, D. R. (1958). Planning of Experiments. Wiley, New York.
  Google Scholar
• 9 Endophthalmitis Vitrectomy Study Group. Results of the Endophthalmitis Vitrectomy Study (1995). A randomized trial of immediate vitrectomy and of intravenous antibiotics for the treatment of postoperative bacterial endophthalmitis, Archives of Ophthalmology 113, 1479–1496.
  10.1001/archopht.1995.01100120009001

  PubMed Web of Science® Google Scholar
• 10 Fisher, R. A. (1935). The Design of Experiments. Collier Macmillan, London.
  Google Scholar
• 11 Fisher, R. A. (1960). The Design of Experiments, 8th Ed. Hafner, New York.
  Google Scholar
• 12 Flather, M., Pipilis, A., Collins, R. et al. (1994). Randomized controlled trial of oral captopril, of oral isosorbide mononitrate and of intravenous magnesium sulphate started early in acute myocardial infarction: safety and haemodynamic effects, European Heart Journal 15, 608–619.
  10.1093/oxfordjournals.eurheartj.a060556

  CAS PubMed Web of Science® Google Scholar
• 13 Green, A., Battistutta, D., Hart, V., Leslie, D., Marks, G., Williams, G., Gaffney, P., Parsons, P., Hirst, L., Frost, C. et al. (1994). The Nambour Skin Cancer and Actinic Eye Disease Prevention Trial: design and baseline characteristics of participants, Controlled Clinical Trials 15, 512–522.
  10.1016/0197-2456(94)90008-6

  CAS PubMed Web of Science® Google Scholar
• 14 Greenberg, E. R., Baron, J. A., Tosteson, T. D., Freeman, D. H., Jr, Beck, G. J., Bond, J. H., Colacchio, T. A., Coller, J. A., Frankl, H. D., Haile, R. W., Mandel, R. W., Nierenberg, J. S., Rothstein, D. W., Richard, S., Dale, C., Stevens, M. M., Summers, R. W. & vanStolk, R. U. (1994). A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group, New England Journal of Medicine 331, 141–147.
  10.1056/NEJM199407213310301

  CAS PubMed Web of Science® Google Scholar
• 15 Heinonen, O. P., Virtamo, J., Albanes, D. et al. (1987). Beta carotene, alpha-tocopherol lung cancer intervention trial in Finland, in Proceedings of the XI Scientific Meeting of the International Epidemiologic Association, Helsinki, August, 1987. Pharmy, Helsinki.
  Google Scholar
• 16 Hennekens, C. H. & Eberlein, K. (1985). A randomized trial of aspirin and beta-carotene among U.S. physicians, Preventive Medicine 14, 165–168.
  10.1016/0091-7435(85)90031-3

  CAS PubMed Web of Science® Google Scholar
• 17 ISIS-4 Collaborative Group (1995). ISIS-4: a randomized factorial trial assessing early captopril, oral mononitrate, and intravenous magnesium-sulphate in 58 050 patients with suspected acute myocardial infarction, Lancet 345, 669–685.
  10.1016/S0140-6736(95)90865-X

  PubMed Web of Science® Google Scholar
• 18 Lacourciere, Y., Lefebvre, J., Poirier, L., Archambault, F. & Arnott, W. (1994). Treatment of ambulatory hypertensives with nebivolol or hydrochlorothiazide alone and in combination. A randomized double-blind, placebo-controlled, factorial-design trial, American Journal of Hypertension 7, 137–145.
  10.1093/ajh/7.2.137

  CAS PubMed Web of Science® Google Scholar
• 19 Li, B., Taylor, P. R., Li, J. Y., Dawsey, S. M., Wang, W., Tangrea, J. A., Liu, B. Q., Ershow, A. G., Zheng, S. F., Fraumeni, J. F., Jr et al. (1993). Linxian nutrition intervention trials. Design, methods, participant characteristics, and compliance, Annals of Epidemiology 3, 577–585.
  10.1016/1047-2797(93)90078-I

  CAS PubMed Google Scholar
• 20 Lubsen, J. & Pocock, S. J. (1994). Factorial trials in cardiology (editorial), European Heart Journal 15, 585–588.
  10.1093/oxfordjournals.eurheartj.a060552

  CAS PubMed Web of Science® Google Scholar
• 21 Mason, R. L. & Gunst, R. L. (1989). Statistical Design and Analysis of Experiments. Wiley, New York.
  Google Scholar
• 22 Max, M. B., Zeigler, D., Shoaf, S. E., Craig, E., Benjamin, J., Li, S. H., Buzzanell, C., Perez, M. & Ghosh, B. C. (1992). Effects of a single oral dose of desipramine on postoperative morphine analgesia, Journal of Pain & Symptom Management 7, 454–462.
  10.1016/0885-3924(92)90131-Z

  CAS PubMed Web of Science® Google Scholar
• 23 Parkinson Study Group (1993). Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease, New England Journal of Medicine 328, 176–183.
  10.1056/NEJM199301213280305

  PubMed Web of Science® Google Scholar
• 24 Piantadosi, S. (1997). Factorial designs, in Clinical Trials: a Methodologic Perspective. Wiley, New York. See Chapter 15.
  Google Scholar
• 25 Pordy, R. C. (1994). Cilazapril plus hydrochlorothiazide: improved efficacy without reduced safety in mild to moderate hypertension. A double-blind placebo-controlled multi-center study of factorial design, Cardiology 85, 311–322.
  10.1159/000176704

  CAS PubMed Web of Science® Google Scholar
• 26 Schellhammer, P., Shariff, R., Block, N., Soloway, M., Venner, P., Patterson, A. L., Sarosdy, M., Vogelzang, N., Jones, J. & Kiovenbag, G. (1995). A controlled trial of bicalutamide versus flutamide, each in combination with lutenizing hormone-releasing hormone analogue therapy, in patients with advanced prostate cancer. Casodex Combination Study Group, Urology 45, 745–752.
  10.1016/S0090-4295(99)80077-6

  PubMed Web of Science® Google Scholar
• 27 Slud, E. V. (1994). Analysis of factorial survival experiments, Biometrics 50, 25–38.
  10.2307/2533194

  CAS PubMed Web of Science® Google Scholar
• 28 Snedecor, G. W. & Cochran, W. G. (1980). Statistical Methods, 7th Ed. The Iowa State University Press, Ames.
  CAS Google Scholar
• 29 Sperduto, R. D., Hu, T. S., Milton, R. C., Zhao, J. L., Everett, D. F., Cheng, Q. F., Blot, W. J., Bing, L., Taylor, P. R., Li, J. Y. et al. (1993). The Linxian cataract studies. Two nutrition intervention trials, Archives of Ophthalmology 111, 1246–1253.
  10.1001/archopht.1993.01090090098027

  CAS PubMed Web of Science® Google Scholar
• 30 Stampfer, M. J., Buring, J. E., Willett, W. et al. (1985). The 2 × 2 factorial design: its application to a randomized trial of aspirin and carotene in U.S. physicians, Statistics in Medicine 4, 111–116.
  10.1002/sim.4780040202

  CAS PubMed Web of Science® Google Scholar
• 31 Steering Committee of the Physicians' Health Study Research Group (1989). Final report on the aspirin component of the ongoing physicians' health study. New England Journal of Medicine 321, 129–135.
  10.1056/NEJM198907203210301

  PubMed Web of Science® Google Scholar
• 32 Thornquist, M. D., Owenn, G. S., Goodman, G. E. et al. (1993). Statistical design and monitoring of the carotene and retinol efficacy trial (CARET), Controlled Clinical Trials 14, 308–324.
  10.1016/0197-2456(93)90228-6

  CAS PubMed Web of Science® Google Scholar
• 33 Yates, F. (1935). Complex experiments (with discussion), Journal of the Royal Statistical Society, Series B 2, 181–247.
  10.2307/2983638

  Google Scholar

Encyclopedia of Biostatistics

Browse other articles of this reference work:

• BROWSE BY TOPIC
• BROWSE A-Z

• References

• Related

• Information

Close Figure Viewer

Previous FigureNext Figure

Caption